Subacute-Onset Afferent Ataxia in Childhood: A Case Report

2019 ◽  
Vol 18 (04) ◽  
pp. 190-194
Author(s):  
Vanessa Cecchin ◽  
Serena Pellegrin ◽  
Lucio Parmeggiani ◽  
Lydia Pescollderungg ◽  
Federico Mercolini

AbstractAcute or subacute ataxia in young children is rare and, in most cases, the diagnosis of the underlying etiology can be challenging. An extensive number of possible causes must be considered when approaching a child with ataxia. We report the case of a 21-month-old girl with subacute-onset rapidly progressive ataxia, occurring few days after a gastrointestinal infection, without clear reduction of muscle strength in the limbs or other neurological signs. The development of a mild hyporeflexia of the lower limbs, thereafter, led to the suspicion of a Guillain–Barré syndrome (GBS) that was confirmed by appropriate investigations. This case confirms that a subacute afferent ataxia can be the main clinical symptom of GBS in young children, in whom this disease is rare and the diagnosis more challenging. Attention must be paid to the presence of other neurological signs that can lead to the diagnosis.

2021 ◽  
Author(s):  
Louis Fernando Marques de Almeida ◽  
Déborah Inayara Mendes Tenório de Albuquerque ◽  
Érico Induzzi Borges ◽  
Marcele Schettini ◽  
Herval Ribeiro Soares Neto ◽  
...  

Introduction: Guillain-Barré syndrome is an acute/subacute set of clinical features of immune mediated polyradiculoneuropathy, typically after respiratory or gastrointestinal viral infection. In this scenario, we described a case of the syndrome mentioned after infection by sars-cov-2 virus. Objectives and Methods: Description of a clinical case after analysis of medical history and complementary exams, in addition to literature review. Design and Setting: Case report, type of descriptive study, developed in the Institute of Medical Assistance to the State Public Servant of São Paulo. Results: A 68-year-old female patient with clinical and laboratory diagnosis of coronavirus infection, hospitalized in need of oxygen supplementation, which evolved after twelve days of symptoms with hypoesthesia on legs and feet and progressively ascending and symmetrical flaccid paraparesis that led to tetraparesis. Neurological examination showed tetraparesis (muscle strength: grade III in MMSS and grade II in MMII), hyporeflexia in MMSS and reflexes abolished in the lower limbs, plantar skin reflex in flexion in both feet, preserved facial mimicry. About complementary tests, it presented cerebrospinal fluid with albuminocytologic dissociation (cell: 1, protein: 89, glucose: 86), RT-PCR for sars-cov-2 research in cerebrospinal fluid, inconclusive, in addition to four-limb electroneuromyography performed after 19 days of onset of neurological condition, indicated polyradiculoneuropathy with involvement of sensory and motor fibers, primarily demyering. Treatment with human immunoglobulin 400 mg/kg/day for 05 days was started. The reported patient was dismissed from the hospital with significant improvement, presenting muscle strength: grade V in MMSS and grade IV in MMII and already with the ability to walk. Conclusions: the case describes a classic neurological complication associated with a virus that was once non-circulating, but currently with a big clinical relevance.


2021 ◽  
Vol 8 (9) ◽  
pp. 548-550
Author(s):  
Chinnu Roy ◽  
Jobin Kunjumon Vilapurathu ◽  
Dhanya Paul

Guillain Barre Syndrome (GBS) is an autoimmune disorder which affects the peripheral nervous system. It is a rare disorder affects in 1 per million people in year. It is characterized by symmetrical, progressive limb weakness and tingling. Case Report: A 53 year old male patient was presented with insidious onset of difficulty in moving right upper and lower limbs as well as gradual weakness of left limbs, and breathing difficulty, known case of diabetics’ mellitus and hypertension. Nerve conduction study shows suggest axonopathy; Acute Inflammatory Demyelinating Polyneuropathy (AIDP) is identified, which is a subtype of Guillain Barre Syndrome. Patient gradually develops areflexia, bifacial weakness, and quadriparesis. Patient was treated with IV immunoglobulin and intranasal oxygen therapy. Patient shows slight improvement in his medical condition, shows improvement in the power of lower limbs after one week of therapy. Physiotherapy was suggested. Keywords: Guillain Barre Syndrome, GBS, Acute Inflammatory Demyelinating Polyneuropathy, AIDP.


Author(s):  
Navid Manouchheri ◽  
Omid Mirmosayyeb ◽  
Majid Ghasemi ◽  
Shervin Badihian ◽  
Vahid Shaygannejad ◽  
...  

Introduction: Guillain-Barre Syndrome is an uncommon complication during acute brucellosis. Case presentation: In this study, we present a case of Guillain-Barre Syndrome in a 22-year old male patient with complaints of weakness in his lower limbs. He had a history of acute Brucella infection for four months and received antimicrobial medication. Conclusion: the patients can be affected by GBS after antimicrobial treatment.


2019 ◽  
pp. 1-7

Abstract Guillain Barré Syndrome (GBS) is an acute single-phase causal disease that occurs after an infection. An analysis ranges from 0.5-1.5/100,000 children, predominates in males. Initiatives with the limbs followed by progressive, symmetrical muscle weakness, with the principle of lower nodes (lower limbs). In children, the predominance is the difficulty of gait and greater involvement of the cranial pairs. Young children are difficult to diagnose because they have atypical complaints and a more challenging neurological examination. In case of suspicion, the patient should be hospitalized in a pediatric ICU, where he/she should remain monitored, with frequent surveillance and treatment should not be delayed, reducing the frequency and severity of complications.


2020 ◽  
Vol 20 (2) ◽  
pp. 227
Author(s):  
Danah Aljaafari ◽  
Noman Ishaque

Guillain-Barré syndrome (GBS) is a heterogeneous disorder with a diverse clinical presentation ranging from weakness of certain body regions to tetraparesis with autonomic dysfunction and respiratory failure. Paraparetic GBS is a variant of GBS which is characterised by weakness limited to the lower limbs only. It is crucial to identify such topographical presentations, as a delay in diagnosis can lead to delayed initiation of specific treatment, which can negatively impact the outcome. We report a 29-year-old female patient who presented to the King Fahd Hospital of the University, Al Khobar, Saudi Arabia, in 2017 with rapid onset asymmetrical weakness of lower extremities associated with bladder dysfunction during the immediate postpartum period. The weakness spared cranial nerves and arms and imaging studies of the spine was unremarkable. Cerebrospinal fluid investigations showed cyto-albuminologic dissociation and nerve conduction studies showed features of demyelination. The patient was diagnosed with a paraparetic variant of GBS and treated with intravenous immunoglobulin. She had almost recovered completely at the two–month follow-up.Keywords: Paraparesis; Guillain-Barré Syndrome; Demyelination; Postpartum Period; Case Report; Saudi Arabia.


2021 ◽  
Author(s):  
Gabriel Santaterra Barros ◽  
Ana Paula Ramires Chiminazzo ◽  
Maria Luiza Ricarte Ruggeri ◽  
Maria Luisa Pelaes Stipp ◽  
Helen Maia Tavares de Andrade

Context: areflexia and hyporeflexia are mandatory clinical criteria for the diagnosis of Guillain-Barré Syndrome (GBS). However there are case reports in literature of GBS that exhibit hyperreflexia. Case report: Male patient, 38 years old, after weakness and pain in lower limbs, after exercise, for 4 days, without alteration of balance and sphincter. A week earlier, he had diarrhea and fever. Previous bariatric surgery. On examination: For both upper limbs, the grade of power was 5/5 in the proximal muscle group and 4/5 in the distal muscle group. For the lower limbs, the grade of power was 4/5 in both proximal and distal muscle groups. The deep tendon reflexes were brisk (+2) throughout all four limbs. Patellar tendon reflex had bigger response (+3). Babinski’s and Hoffmann’s signs were negative. Tactile, painful, vibrating sensitivity and cranial nerves examination were all intact. The presence of reflex in the four limbs with patellar hyperreflexia, made the GBS hypothesis to be disregarded. Laboratory: normal CK, TGO, aldolase, TGP, LDH and vitamin B12. Electroneuromyography (ENMG) revealed the diagnosis of AMAN. After ENMG, cerebrospinal fluid known as leukocytes: 3.1 mm³, proteins: 95.2 mg/dl. Human immunoglobulin (0.4 g/ kg/day) was prescribed for 5 days and the patient recovered in 3 months. Conclusions: The case reported by us shows the importance to take into account the GBS hypothesis in the presence of hyperreflexia, especially in axonal variants, to prevent the treatment from being mistakenly postponed.


2020 ◽  
Vol 23 (10) ◽  
pp. 718-721
Author(s):  
Mojgan Agha Abbaslou ◽  
Maryam Karbasi ◽  
Hossein Mozhdehipanah

Guillain–Barré syndrome (GBS) is a neurological disorder accompanied by several neurological signs and symptoms including progressive weakness and diminished or decreased reflexes. GBS was reported as one of the several neurological complications in MERS-CoV and SARS-CoV outbreaks. Several studies have reported GBS as a neurological complication in recent COVID-19 outbreak. We report on the case of a 55-years -old female who was hospitalized with dyspnea, dry cough, and myalgia. She developed Acute Motor & Sensory Axonal Neuropathy (AMSAN), a rare variant of GBS signs and symptoms including decreased muscle strength and pinprick sensation in both lower extremities during her hospitalization.


Medicine ◽  
2019 ◽  
Vol 98 (15) ◽  
pp. e15014
Author(s):  
Kévin Diallo ◽  
Caroline Jacquet ◽  
Corentine Alauzet ◽  
Isabelle Beguinot ◽  
Thierry May ◽  
...  

2021 ◽  
pp. 1-5
Author(s):  
Amr Hassan ◽  
Alaa El-Mazny ◽  
Mohammed Saher ◽  
Ismail Ibrahim Ismail ◽  
Mohammed Almuqbil

Guillain-Barre syndrome (GBS) and multiple sclerosis (MS) are autoimmune demyelinating disorders of the peripheral and central nervous systems, respectively. The co-occurrence of these 2 conditions is rare in the literature. Herein, we present a rare case of GBS and MS in a 19-year-old female who presented initially with GBS followed by MS, and we provide a literature review. Despite being rare, it should be kept in mind in the differential diagnosis of patients with atypical and usual presentation of both diseases.


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