The Use of Logistic Analysis to Distinguish between Normal and Pre-Eclamptic Patients

1975 ◽  
Author(s):  
P. W. Howie ◽  
D. Purdie ◽  
C. Begg ◽  
C. D. Forbes ◽  
C. R. M. Prentice
Keyword(s):  
Factor Viii ◽  
Pregnant Women ◽  
Fetal Death ◽  
Clinical Deterioration ◽  
Single Test ◽  
Fibrin Deposition ◽  
Intravascular Coagulation ◽  
Logistic Analysis ◽  
Range Of Values ◽  
Coagulation And Fibrinolysis

Tests of coagulation and fibrinolysis were performed in 20 patients with severe preeclampsia and in 20 normal pregnant women. Compared with the normal patients, the women with severe pre-eclampsia had raised factor VIII, increased cryofibrinogen and reduced platelet counts. Despite increased resistance to urokinase-induced fibrinolysis, the pre-eclamptic women had lower plasminogen and increased serum and urinary F.D.P. levels. These results suggested that intravascular fibrin deposition was a feature of severe pre-eclampsia. In each test, the range of values in the pre-eclamptic women overlapped with the controls, so that no single test indicated whether intravascular coagulation was present in every case of severe pre-eclampsia. By the use of logistic analysis, it was possible to demonstrate that an abnormality of the coagulation and fibrinolytic systems was present in every case of severe pre-eclampsia. In 10 patients with moderate pre-eclampsia, the severity of the coagulation abnormality was intermediate between the severe cases and the controls.By sequential logistic analysis, it may be possible to anticipate the phase of clinical deterioration and permit delivery before the onset of fetal death. The haemostatic abnormalities would appear to be a constant and inevitable feature of pre-eclampsia.

scholarly journals Integrated assessment haemostasis pregnant women with gestosis

2013 ◽  
Vol 62 (4) ◽  
pp. 15-21
Author(s):  
Sergey Vladimirovich Barinov ◽  
Vladimir Terent'evich Dolgikh ◽  
Irina Vladimirovna Medyannikova
Keyword(s):  
Pregnant Women ◽  
Integrated Assessment ◽  
Intravascular Coagulation ◽  
Fibrinolysis Activity ◽  
In Pregnancy ◽  
Coagulation And Fibrinolysis

The parameters of the kaolinaktivirovannoy thrombelastographic at physiological gestation, moderate, and severe gestosis. The significant differences between groups for the intensification of intravascular coagulation and fibrinolysis activity. Option and the severity of the changes thrombelastographic determine the need for correction hemocoagulation violations during gestation thrombohemorrhagic to prevent complications in pregnancy.

scholarly journals Integrated assessment haemostasis pregnant women with gestosis

2013 ◽  
Vol 62 (6) ◽  
pp. 5-11
Author(s):  
Sergey Vladimirovich Barinov ◽  
Vladimir Timofeevich Dolgikh ◽  
Irina Vladimirovna Medyannikova
Keyword(s):  
Pregnant Women ◽  
Integrated Assessment ◽  
Intravascular Coagulation ◽  
Fibrinolysis Activity ◽  
In Pregnancy ◽  
Coagulation And Fibrinolysis

The parameters of the kaolinaktivirovannoy thrombelastographic at physiological gestation, moderate, and severe gestosis. The significant differences between groups for the intensification of intravascular coagulation and fibrinolysis activity. Option and the severity of the changes thrombelastographic determine the need for correction hemocoagulation violations during gestation thrombohemorrhagic to prevent complications in pregnancy.

Disseminated intravascular coagulation in meningococcal sepsis

2003 ◽  
Vol 23 (03) ◽  
pp. 125-130 ◽  
Author(s):  
S. Zeerleder ◽  
R. Zürcher Zenklusen ◽  
C. E. Hack ◽  
W. A. Wuillemin
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Skin Necrosis ◽  
Multiple Organ ◽  
Meningococcal Sepsis ◽  
Multiple Organ Dysfunction ◽  
Intravascular Coagulation ◽  
Therapeutic Concepts ◽  
New Therapeutic Concepts ◽  
Coagulation And Fibrinolysis

SummaryWe report on a man (age: 49 years), who died from severe meningococcal sepsis with disseminated intravascular coagulation (DIC), multiple organ dysfunction syndrome and extended skin necrosis. We discuss in detail the pathophysiology of the activation of coagulation and fibrinolysis during sepsis. The article discusses new therapeutic concepts in the treatment of disseminated intravascular coagulation in meningococcal sepsis, too.

Fibrin Derivatives, Plasma Hemoglobin and Glomerular Fibrin Deposition in Experimental Intravascular Coagulation

1973 ◽  
Vol 29 (02) ◽  
pp. 363-374 ◽  
Author(s):  
F. K Beller ◽  
W Theiss
Keyword(s):  
Quantitative Measurement ◽  
Plasma Fibrinogen ◽  
Moderate Increase ◽  
Consumption Coagulopathy ◽  
Fibrin Deposition ◽  
Intravascular Coagulation ◽  
Plasma Hemoglobin ◽  
Three Stages ◽  
Two Parameters ◽  
Gelation Test

SummaryPlasma fibrinogen, circulating fibrinmonomers (as indicated by a positive ethanol gelation test), fibrinolysis breakdown products and plasma hemoglobin were assayed in 122 rats subjected to endotoxin injection or infusion. The results were correlated with the quantitative measurement of glomerular fibrin deposition. Based on these data four groups were determined : consumption coagulopathy and three stages of increasing severity of disseminated intravascular coagulation (DIG).Consumption coagulopathy was defined by a decrease in plasma fibrinogen and a positive ethanol gelation test in the absence of glomerular fibrin deposition. Plasma hemoglobin and fibrinolysis breakdown products were normal or only slightly increased.DIG as characterized by glomerular fibrin deposition was defined as moderate (1 to 20% glomeruli showing fibrin strands), intermediate (21 to 80%), and severe (81 to 100%). Decrease in plasma fibrinogen and frequence of a positive ethanol gelation test in all stages of DIG were only slightly different from the findings in consumption coagulopathy. However, a sharp increase in plasma hemoglobin levels was noted when glomerular fibrin deposition did occur even in small amounts. At this time only a moderate increase was noted in fibrin(ogen) breakdown products. These two parameters increased only slightly in the group of intermediate DIG. Severe DIG was characterized by a massive increase in fibrin (ogen) breakdown products and high levels of plasma hemoglobin.

scholarly journals Factors Related to Fetal Death in Pregnant Women with Cholera, Haiti, 2011–2014

2016 ◽  
Vol 22 (1) ◽  
pp. 124-127 ◽  
Author(s):  
Erin Schillberg ◽  
Cono Ariti ◽  
Lindsay Bryson ◽  
Rodnie Delva-Senat ◽  
Debbie Price ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Fetal Death

scholarly journals PENGETAHUAN IBU HAMIL TENTANG BAHAYA MEROKOK TERHADAP KEHAMILAN DAN JANIN

2020 ◽  
Vol 3 (1) ◽  
pp. 91
Author(s):  
Melva Manurung
Keyword(s):  
Health Education ◽  
Pregnant Women ◽  
Fetal Development ◽  
Neonatal Death ◽  
Fetal Death ◽  
Additional Material ◽  
Smoking During Pregnancy ◽  
Respiratory Problems ◽  
The Public ◽  
Almost All

Smoking during pregnancy can endanger pregnancy and the fetus, especially the health of pregnant women and fetal development in the womb. One of the complications of pregnancy that causes fetal death is due to oxygenation disorders. In Indonesia, more than half of households have at least one smoker, and almost all smokers’ smokes at home. The cause of neonatal death is fetal death in utero, asphyxia or respiratory problems due to smoking and premature. This study aims to determine the knowledge of pregnant women about the dangers of smoking to pregnancy and the fetus in Gasaribu Village, Laguboti, Toba Samosir Regency. This research was conducted in September-October 2019 using adescriptive research design. The number of samples was in this study were 40 pregnant women. Sampling is done by using saturated sampling. The results showed that good knowledge of 16 people (40%) was enough 22 people (55%) and less 2 people (5%).  The results of this study are expected to be used as additional material in adding knowledge and information to increase real health education (real) to the public about the dangers of smoking to pregnancy and the fetus.

scholarly journals Maternal and perinatal outcomes of hyperthyroidsm in pregnancy at Dr. Cipto Mangunkusumo Hospital, Jakarta, period of January 2015 - December 2016

2021 ◽  
Vol 29 (1) ◽  
pp. 36
Author(s):  
Fita Maulina ◽  
M Adya F F Dilmy ◽  
Ali Sungkar
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Intrauterine Growth Restriction ◽  
Fetal Death ◽  
Perinatal Outcomes ◽  
Growth Restriction ◽  
Intrauterine Fetal Death ◽  
Adequate Treatment ◽  
Intrauterine Growth ◽  
In Pregnancy

Objectives: To report maternal and perinatal outcomes of hyperthyroidsm in pregnancy.Case Report: There were 3622 cases of delivering pregnant women during the period of the study. From this number, the prevalence of pregnant women with hyperthyroid was 0.2 %. We reported 9 cases of hyperthyroid in pregnancy. The number of pregnancy complication and outcome on pregnant women with hyperthyroidism were preterm labor (44%) and preeclampsia (22%), both were found in group of mother who did taking antihyperthyroid therapy. In those who did not take antihyperthyroid therapy 11% had spontaneous abortion and 11% had preterm delivery. Fetal complications were intrauterine growth restriction (11%) and intrauterine fetal death (23%), both of these complication were on the group who did not take antihyperthyroid. On the contrary, 44% babies were born with normal birthweight in group who took antihyperthyroid.Conclusion: There were differences noted between the group that took adequate treatment and the group that did not take antihyperthyroid. The incidence of intrauterine growth restriction and intrauterine fetal death were high in group that did not took antihyperthyroid therapy but the incidence of preterm delivery as the maternal complication was high in group that did take the antihyperthyroid therapy.  

Criteria for prediction of antenatal fetal death in diabetic pregnant women

2000 ◽  
Vol 70 ◽  
pp. D82-D82
Author(s):  
N. Solonets ◽  
V. Medved ◽  
I. Gordienko ◽  
E. Romanenko
Keyword(s):  
Pregnant Women ◽  
Fetal Death

Therapeutical Effects of Heparin and Aprotinin on Experimental Disseminated Intravascular Coagulation in the Rat

1975 ◽  
Author(s):  
H. Heyes ◽  
B. Slijepcevic ◽  
D. Glück
Keyword(s):  
Single Dose ◽  
Disseminated Intravascular Coagulation ◽  
Bolus Injection ◽  
Fibrinogen Level ◽  
Isotonic Saline ◽  
Plasma Fibrinogen Level ◽  
Fibrin Deposition ◽  
Intravascular Coagulation ◽  
Fibrin Thrombi ◽  
Fibrin Monomers

A disseminated intravascular coagulation (DIC) was induced in rats by injection of 1 mg endotoxin and subsequent infusion of isotonic saline (500 ml/kg/5 hours) over a period of 5 hours. Animals were treated beginning at the time of initial glomerular fibrin deposition with heparin (1000 IU/kg) or aprotinin (40000 KIU/kg) or heparin-aprotinin in combination (each drug as given as in single dose). The first half-dasc was given as an bolus injection 2 hours after the endotoxin injection, the second dose immediately was added to the saline infusion. The extent of DIC was controlled by several blocdparameters, histological examination of the kidneys, and by the application of 125–I-fibrinogen (given after starting DIC) and 131-I-fibrinogen (injected after beginning the therapy). By the use of two isotopes it was possible to observe the behaviour of the fibrinogen in two different phases.Heparin had clearly favorable effects stabilizing the situation of hemostasis, although the fibrinogen turnover was not normalised completely, probably due to fibrin monomers which even polymerize in presence of heparin. The beneficious effect of heparin was diminished by the addition of aprotinin which given alone had deleterious effects inhibiting the spontaneous removal of fibrin thrombi. The fibrinogen turnover was clearly enhanced supporting the concept that the plasma fibrinogen level cannot be protected by blocking the fibrinolysis which is very rarely generalized.

Sign in / Sign up

Export Citation Format

Share Document