CLINICAL VALIDATION OF BLI ADENOMAS SERRATED INTERNATIONAL CLASSIFICATION (BASIC) FOR RESECT AND DISCARD STRATEGY FOR DIMINUTIVE COLORECTAL POLYPS (BIRD STUDY)

2020 ◽  
Author(s):  
E Rondonotti ◽  
C Hassan ◽  
A Andrealli ◽  
S Paggi ◽  
A Amato ◽  
...  
Keyword(s):  
Colorectal Polyps ◽  
International Classification ◽  
Clinical Validation

scholarly journals Clinical validation of the SIMPLE classification for optical diagnosis of colorectal polyps

2021 ◽  
Vol 09 (05) ◽  
pp. E684-E692
Author(s):  
Ahmed Amine Alaoui ◽  
Kussil Oumedjbeur ◽  
Roupen Djinbachian ◽  
Étienne Marchand ◽  
Paola N. Marques ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Colorectal Polyps ◽  
Clinical Validation ◽  
Optical Diagnosis ◽  
Clinical Cohort ◽  
Simple Classification ◽  
Surveillance Interval ◽  
Colonoscopy Surveillance ◽  
Secondary Outcomes ◽  
Diagnosis Classification

Abstract Background and study aims A novel endoscopic optical diagnosis classification system (SIMPLE) has recently been developed. This study aimed to evaluate the SIMPLE classification in a clinical cohort. Patients and methods All diminutive and small colorectal polyps found in a cohort of individuals undergoing screening, diagnostic, or surveillance colonoscopies underwent optical diagnosis using image-enhanced endoscopy (IEE) and the SIMPLE classification. The primary outcome was the agreement of surveillance intervals determined by optical diagnosis compared with pathology-based results for diminutive polyps. Secondary outcomes included the negative predictive value (NPV) for rectosigmoid adenomas, the percentage of pathology exams avoided, and the percentage of immediate surveillance interval recommendations. Analysis of optical diagnosis for polyps ≤ 10 mm was also performed. Results 399 patients (median age 62.6 years; 55.6 % female) were enrolled. For patients with at least one polyp ≤ 5 mm undergoing optical diagnosis, agreement with pathology-based surveillance intervals was 93.5 % (95 % confidence interval [CI] 91.4–95.6). The NPV for rectosigmoid adenomas was 86.7 % (95 %CI 77.5–93.2). When using optical diagnosis, pathology analysis could be avoided in 61.5 % (95 %CI 56.9–66.2) of diminutive polyps, and post-colonoscopy surveillance intervals could be given immediately to 70.9 % (95 %CI 66.5–75.4) of patients. For patients with at least one ≤ 10 mm polyp, agreement with pathology-based surveillance intervals was 92.7 % (95 %CI 89.7–95.1). NPV for rectosigmoid adenomas ≤ 10 mm was 85.1 % (95 %CI CI 76.3–91.6). Conclusions IEE with the SIMPLE classification achieved the quality benchmark for the resect and discard strategy; however, the NPV for rectosigmoid polyps requires improvement.

scholarly journals A79 CLINICAL VALIDATION OF THE SIMPLE CLASSIFICATION FOR OPTICAL DIAGNOSIS OF DIMINUTIVE AND SMALL COLORECTAL POLYPS

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 93-94
Author(s):  
A Alaoui ◽  
K Oumedjbeur ◽  
R Djinbachian ◽  
E Marchand ◽  
P Marques ◽  
...  
Keyword(s):  
Colorectal Polyps ◽  
Adenomatous Polyps ◽  
Prospective Clinical Study ◽  
Study Cohort ◽  
Clinical Validation ◽  
The Novel ◽  
Optical Diagnosis ◽  
Simple Classification ◽  
Funding Agencies ◽  
Surveillance Interval

Abstract Background Image enhanced endoscopy (IEE) allows for real-time optical diagnosis of colorectal polyps in order to replace histopathology. A novel classification system (SIMPLE classification) has recently been developed for optical diagnosis when using the novel Pentax Optivista IEE platform. Aims The aim of this study was to evaluate the SIMPLE classification for optical polyp diagnosis in a prospective clinical study. Methods Patients undergoing screening, diagnostic or surveillance colonoscopies were enrolled in the study. All colorectal polyps 1-10mm found underwent optical polyp diagnosis using the SIMPLE classification with either iScan or Optivista for image-enhanced endoscopy (IEE). Polyps were resected as per standard care and sent for histopathology analysis. Optical diagnosis and surveillance intervals were calculated based on SIMPLE criteria and compared to pathology-based results as reference. Primary outcome was the agreement of the surveillance intervals based on the SIMPLE classification with pathology-based surveillance intervals for 1-5mm colorectal polyps. Secondary outcomes included negative predictive value (NPV) for rectosigmoid adenoma, percentage of pathology avoided, percentage of post-colonoscopy immediate recommendations, and surveillance interval agreement, rectosigmoid NPV for 1-10mm polyps. Results 399 patients (mean age: 62.4, 55.6% female) with 278 diminutive and 364 small polyps were evaluated in the study cohort. For ≤5mm polyps, agreement with pathology-based surveillance intervals was 93.5% [95% CI 91.1–95.9] (shorter: 4.5% [95% CI 2.5–6.5]; longer: 1.8% [95% CI 0.5–3.0]). NPV for rectosigmoid adenomatous polyps (including SSA) was 85.5% [95% CI 77.6–93.4]. Using Optical diagnosis and the SIMPLE classification, pathology analysis could be avoided in 61.5% [95% CI 56.9–66.2] of polyps and post-colonoscopy immediate surveillance interval recommendation could be given in 70.9% [95% CI 66.5–75.4] of patients. For ≤10mm polyps, agreement with pathology-based surveillance intervals was 92.2% [95% CI 89.6–94.9] (shorter: 5.5% [95% CI 3.3–7.8]; longer: 2.3% [95% CI 0.8–3.7]). NPV for rectosigmoid adenomatous polyps (including SSA) was 83.7% [95% CI 75.9–91.5]. Conclusions The first clinical validation study using the SIMPLE classification in combination with Optivista or iScan IEE showed a high (≥90%) surveillance interval agreement compared to pathology. More than 60% of pathology could be avoided, and most patients could be given immediate surveillance intervals when using IEE in combination with the SIMPLE classification. Funding Agencies NonePentax

scholarly journals Mo1624 CLINICAL VALIDATION OF THE SIMPLE CLASSIFICATION FOR OPTICAL DIAGNOSIS OF DIMINUTIVE AND SMALL COLORECTAL POLYPS

2020 ◽  
Vol 91 (6) ◽  
pp. AB424-AB425
Author(s):  
Ahmed Amine Alaoui ◽  
Kussil Oumedjbeur ◽  
Roupen Djinbachian ◽  
Etienne Marchand ◽  
Paola Marques ◽  
...  
Keyword(s):  
Colorectal Polyps ◽  
Clinical Validation ◽  
Optical Diagnosis ◽  
Simple Classification

Clinical Validation of BASIC Classification for the Resect and Discard Strategy for Diminutive Colorectal Polyps

2020 ◽  
Vol 18 (10) ◽  
pp. 2357-2365.e4 ◽  
Author(s):  
Emanuele Rondonotti ◽  
Cesare Hassan ◽  
Alida Andrealli ◽  
Silvia Paggi ◽  
Arnaldo Amato ◽  
...  
Keyword(s):  
Colorectal Polyps ◽  
Clinical Validation

OC.16.5 CLINICAL VALIDATION OF BLI ADENOMAS SERRATED INTERNATIONAL CLASSIFICATION (BASIC) FOR RESECT AND DISCARD STRATEGY (BIRD STUDY)

2020 ◽  
Vol 52 ◽  
pp. S50-S51
Author(s):  
E. Rondonotti ◽  
C. Hassan ◽  
A. Andrealli ◽  
S. Paggi ◽  
A. Amato ◽  
...  
Keyword(s):  
International Classification ◽  
Clinical Validation

scholarly journals Optical diagnosis of colorectal polyps with Blue Light Imaging using a new international classification

2019 ◽  
Vol 7 (2) ◽  
pp. 316-325 ◽  
Author(s):  
Sharmila Subramaniam ◽  
Bu Hayee ◽  
Patrick Aepli ◽  
Erik Schoon ◽  
Milan Stefanovic ◽  
...  
Keyword(s):  
Blue Light ◽  
Colorectal Polyps ◽  
International Classification ◽  
Optical Diagnosis

Holistic Communication Assessment for Young Children With Cleft Palate Using the International Classification of Functioning, Disability and Health:Children and Youth

2020 ◽  
Vol 51 (4) ◽  
pp. 914-938
Author(s):  
Anna Cronin ◽  
Sharynne McLeod ◽  
Sarah Verdon
Keyword(s):  
Young Children ◽  
Cleft Palate ◽  
Case History ◽  
Significant Others ◽  
International Classification ◽  
Assessment Tools ◽  
International Classification Of Functioning ◽  
Speech Language Pathologists ◽  
Holistic Assessment

Purpose Children with a cleft palate (± cleft lip; CP±L) can have difficulties communicating and participating in daily life, yet speech-language pathologists typically focus on speech production during routine assessments. The International Classification of Functioning, Disability and Health: Children and Youth Version (ICF-CY; World Health Organization, 2007 ) provides a framework for holistic assessment. This tutorial describes holistic assessment of children with CP±L illustrated by data collected from a nonclinical sample of seven 2- to 3-year-old children, 13 parents, and 12 significant others (e.g., educators and grandparents). Method Data were collected during visits to participants' homes and early childhood education and care centers. Assessment tools applicable to domains of the ICF-CY were used to collect and analyze data. Child participants' Body Functions including speech, language, and cognitive development were assessed using screening and standardized assessments. Participants' Body Structures were assessed via oral motor examination, case history questionnaires, and observation. Participants' Activities and Participation as well as Environmental and Personal Factors were examined through case history questionnaires, interviews with significant others, parent report measures, and observations. Results Valuable insights can be gained from undertaking holistic speech-language pathology assessments with children with CP±L. Using multiple tools allowed for triangulation of data and privileging different viewpoints, to better understand the children and their contexts. Several children demonstrated speech error patterns outside of what are considered cleft speech characteristics, which underscores the importance of a broader assessment. Conclusion Speech-language pathologists can consider incorporating evaluation of all components and contextual factors of the ICF-CY when assessing and working with young children with CP±L to inform intervention and management practices.

Angststörungen – von der ICD-10 zur ICD-11

2020 ◽  
pp. 1-5
Author(s):  
Timo D. Vloet ◽  
Marcel Romanos
Keyword(s):  
Mental Disorders ◽  
International Classification Of Diseases ◽  
International Classification ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Dsm 5 ◽  
Classification Of Diseases ◽  
Icd 10

Zusammenfassung. Hintergrund: Nach 12 Jahren Entwicklung wird die 11. Version der International Classification of Diseases (ICD-11) von der Weltgesundheitsorganisation (WHO) im Januar 2022 in Kraft treten. Methodik: Im Rahmen eines selektiven Übersichtsartikels werden die Veränderungen im Hinblick auf die Klassifikation von Angststörungen von der ICD-10 zur ICD-11 zusammenfassend dargestellt. Ergebnis: Die diagnostischen Kriterien der generalisierten Angststörung, Agoraphobie und spezifischen Phobien werden angepasst. Die ICD-11 wird auf Basis einer Lebenszeitachse neu organisiert, sodass die kindesaltersspezifischen Kategorien der ICD-10 aufgelöst werden. Die Trennungsangststörung und der selektive Mutismus werden damit den „regulären“ Angststörungen zugeordnet und können zukünftig auch im Erwachsenenalter diagnostiziert werden. Neu ist ebenso, dass verschiedene Symptomdimensionen der Angst ohne kategoriale Diagnose verschlüsselt werden können. Diskussion: Die Veränderungen im Bereich der Angsterkrankungen umfassen verschiedene Aspekte und sind in der Gesamtschau nicht unerheblich. Positiv zu bewerten ist die Einführung einer Lebenszeitachse und Parallelisierung mit dem Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Schlussfolgerungen: Die entwicklungsbezogene Neuorganisation in der ICD-11 wird auch eine verstärkte längsschnittliche Betrachtung von Angststörungen in der Klinik sowie Forschung zur Folge haben. Damit rückt insbesondere die Präventionsforschung weiter in den Fokus.

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