Endoscopic Submucosal Dissection (ESD) Of A Neuroendocrine Tumor Of The Duodenal Bulb Using Dual-Knife-J And Traction With Rubberband/Clip Technique

Objective: To study the therapeutic effect of endoscopic submucosal dissection and mucosal resection on gastric neuroendocrine tumor. Methods: A hundred patients with gastric neuroendocrine tumor that were treated in the Affiliated Hospital of Chifeng University from January 2016 to May 2021 were randomly selected for this research. They were divided into two groups, which were the control group (endoscopic mucosal resection) and the study group (endoscopic submucosal dissection), by the digital table method. The curative effects of the two groups were observed and compared. Results: Before operation, there were no significant differences in serum CgA, TNF-?, and IL-6 between the two groups, p > 0.05. After surgical treatment, the operation time and hospital stay of the patients in the study group were shorter than those in the control group, the amount of surgical bleeding was also less compared to the control group, and the complete tumor resection rate was higher than that in the control group (p < 0.05); the levels of IL-6 and CgA of the study group were lower than those in the control group, while the levels of TNF-? were higher than those of the control group, p < 0.05; the postoperative complication rate of the study group was lower than that of the reference group (p < 0.05). Conclusion: Endoscopic submucosal dissection is more effective for gastric neuroendocrine tumors. The resection rate of the tumor is high, and the operation risk is low.

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P.05.60 ENDOSCOPIC SUBMUCOSAL DISSECTION OF A DUODENAL NEUROENDOCRINE TUMOR WITH LOOP/CLIP-ASSISTED CLOSURE TECHNIQUE

Digestive and Liver Disease ◽

10.1016/s1590-8658(19)30421-9 ◽

2019 ◽

Vol 51 ◽

pp. e208-e209

Author(s):

C. Genco ◽

F. Mazza ◽

D. Stradella ◽

E. Armellini ◽

M. Ballarè ◽

...

Keyword(s):

Endoscopic Submucosal Dissection ◽

Neuroendocrine Tumor ◽

Closure Technique ◽

Submucosal Dissection

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Gastric neuroendocrine tumor treated with endoscopic submucosal dissection

Current Issues in Pharmacy and Medical Sciences ◽

10.1515/cipms-2016-0037 ◽

2016 ◽

Vol 29 (4) ◽

pp. 176-179

Author(s):

Pawel Bojar ◽

Jaroslaw Swatek ◽

Jaroslaw Drabko ◽

Katarzyna Golec ◽

Anna Ostrowska ◽

...

Keyword(s):

Endoscopic Submucosal Dissection ◽

Neuroendocrine Tumor ◽

Effective Treatment ◽

Male Patient ◽

Microscopic Examination ◽

Chromogranin A ◽

Primary Diagnosis ◽

Biopsy Sample ◽

Submucosal Dissection ◽

Proper Diagnosis

Abstract A case of a 59-year-old male patient with gastric neuroendocrine tumor which was misdiagnosed as adenocarcinoma, is presented. Herein, primary diagnosis was made due to the similarity of endoscopic pictures of both diseases and dues to the inappropriate interpretation of a small biopsy sample. The patient was qualified for endoscopic submucosal dissection. Microscopic examination of whole lesion, supplemented by immmunohistochemical reactions (chromogranin A, synaptophysin, cytokeratins 7 and 20, Ki67) revealed gastric neuroendocrine tumor (NET) G2. The lesson learnt is that to provide effective treatment to the patient, it is necessary to use all available methods to make a proper diagnosis and to distinguish the suspected disease from others with similar features.

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Nonampullary duodenal subepithelial neuroendocrine tumor removed R0 by endoscopic submucosal dissection with double clips and rubber band traction

VideoGIE ◽

10.1016/j.vgie.2019.08.006 ◽

2019 ◽

Vol 4 (12) ◽

pp. 570-573 ◽

Cited By ~ 2

Author(s):

Borathchakra Oung ◽

Thomas Walter ◽

Valérie Hervieu ◽

Jérémie Jacques ◽

Mathieu Pioche

Keyword(s):

Endoscopic Submucosal Dissection ◽

Neuroendocrine Tumor ◽

Rubber Band ◽

Submucosal Dissection

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Endoscopic Submucosal Dissection of a Rectal Neuroendocrine Tumor Using Linked Color Imaging Technique

Chinese Medical Journal ◽

10.4103/0366-6999.204937 ◽

2017 ◽

Vol 130 (9) ◽

pp. 1127-1128

Author(s):

Xiao-Tian Sun ◽

Min Min ◽

Yi-Liang Bi ◽

Yang Xu ◽

Yan Liu

Keyword(s):

Endoscopic Submucosal Dissection ◽

Neuroendocrine Tumor ◽

Imaging Technique ◽

Color Imaging ◽

Submucosal Dissection ◽

Linked Color Imaging ◽

Rectal Neuroendocrine Tumor

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Small neuroendocrine tumor of the duodenal bulb: Endoscopic submucosal dissection, laparoscopic and endoscopic cooperative surgery or surgery?

Journal of Digestive Endoscopy ◽

10.4103/0976-5042.180096 ◽

2016 ◽

Vol 07 (01) ◽

pp. 024-026

Author(s):

Nikolaos V. Chrysanthos ◽

Evagelia Anagnostopoulou ◽

Eleni Triga ◽

Stratigoula Sakelariou ◽

Pinelopi Korkolopoulou

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Endoscopic Submucosal Dissection ◽

Duodenal Bulb ◽

Neuroendocrine Neoplasms ◽

Ki 67 ◽

Node Metastasis ◽

Submucosal Dissection ◽

Endoscopic Control ◽

Limited Surgery

AbstractNeuroendocrine neoplasms of the gastric tube are less common than adenocarcinomas. Topography includes stomach, small intestine, Vater ampulla, and gross intestine. They are graded as neuroendocrine tumors grade I and II (NETs GI and GII) and neuroendocrine carcinomas GIII based on Ki-67 index and mitotic count.[1] Endoscopic treatment for GI NETs ≤1 cm that does not extend beyond the submucosal layer and does not demonstrate lymph node metastasis is recommended. Tumors ≥2 cm, with lymph node metastasis, are indicated for surgical treatment. The treatment strategy for tumors between 10 and 20 mm in size remains controversial.[2] We present a rare case of a 60-year-old male patient with end-stage renal failure who underwent a screening pretransplantation endoscopic control. Colonoscopy had no pathological findings. Gastroscopy reveals an abnormal mucosa in the anterior upper part of the duodenal bulb that was described as a micronodular mucosa and a central nodule of 6 mm with erythematous mucosa. Histology of the micronodular mucosa reveals a heterotopic gastric mucosa and a small hyperplastic polyp. Biopsies from the nodule reveal a carcinoid tumor (NET GI). Immunohistochemistry: Positive chromogranin levels, low mitotic index (1/10 HPF), and Ki-67 index <1% [Figure 2]. Gastrin levels were normal and chromogranin levels were abnormal (314 ng/ml, ULN <120 ng/ml). Spiral tomography of the thorax and the abdomen were normal. Endoscopic submucosal dissection is indicated for small NETs (≤1 cm). Laparoscopic and endoscopic cooperative surgery is a novel method, but the experience is limited. Surgery is the best choice for large NETs (>2 cm) and those of the duodenal bulb with histological extensions and the lack of assessing depth invasion.

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