Role of Calcium/Protein Kinase C in the Regulation of DNA Synthesis by Parathyroid Hormone-Related Peptide in Osteoblastic Osteosarcoma Cells

1993 ◽  
Vol 25 (12) ◽  
pp. 608-611 ◽  
Author(s):  
T. Sugimoto ◽  
J. Kano ◽  
T. Yamaguchi ◽  
M. Fukase ◽  
K. Chihara
Keyword(s):  
Protein Kinase C ◽  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Dna Synthesis ◽  
Osteosarcoma Cells ◽  
Related Peptide ◽  
Kinase C ◽  
Parathyroid Hormone Related Peptide ◽  
Osteoblastic Osteosarcoma

Parathyroid hormone stimulates translocation of protein kinase C isozymes in UMR-106 osteoblastic osteosarcoma cells

Bone ◽  
2001 ◽  
Vol 29 (3) ◽  
pp. 223-230 ◽  
Author(s):  
D.A Dossing ◽  
J.M Radeff ◽  
J Sanders ◽  
S.-K Lee ◽  
M.-R Hsieh ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Osteosarcoma Cells ◽  
Kinase C ◽  
Umr 106 ◽  
Osteoblastic Osteosarcoma

PDGF-induced mitogenic signaling is not mediated through protein kinase C and c-fos pathway in VSM cells

1993 ◽  
Vol 264 (1) ◽  
pp. C71-C79 ◽  
Author(s):  
R. V. Sharma ◽  
R. C. Bhalla
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Dna Synthesis ◽  
Thymidine Incorporation ◽  
Cytosolic Calcium ◽  
Platelet Derived Growth Factor ◽  
Kinase C ◽  
Pdgf Stimulation ◽  
Pkc Activation

This study examines the role of protein kinase C (PKC) in platelet-derived growth factor (PDGF)-induced vascular smooth muscle (VSM) cell proliferation and initial signaling events. A 24-h pretreatment of VSM cells with 200 nM phorbol 12-myristate 13-acetate (PMA) completely abolished immunologically reactive PKC activity. Depletion of PKC activity from VSM cells did not attenuate PDGF-stimulated [3H]thymidine incorporation compared with control cells. Similarly, acute activation of PKC by treatment with 200 nM PMA for 10 min had no effect on PDGF-mediated [3H]thymidine incorporation. Both PMA and PDGF increased c-fos induction to the same magnitude; however, treatment with PMA did not induce DNA synthesis in these cells. In PKC-depleted cells PDGF-mediated c-fos induction was reduced by 50-60%, while DNA synthesis in response to PDGF stimulation was not reduced. PKC depletion did not alter PDGF-stimulated increase in cytosolic calcium levels, 125I-PDGF binding, or receptor autophosphorylation. On the basis of these results, we conclude that PKC activation and c-fos induction do not play a significant role in PDGF-mediated mitogenesis in VSM cells.

scholarly journals Dual Regulation of the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Signaling by Protein Kinase C and β-Arrestins

Endocrinology ◽  
2002 ◽  
Vol 143 (10) ◽  
pp. 3854-3865 ◽  
Author(s):  
Marián Castro ◽  
Frank Dicker ◽  
Jean-Pierre Vilardaga ◽  
Cornelius Krasel ◽  
Manfred Bernhardt ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Receptor Signaling ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Kinase C

Role of protein kinase C in the phosphatidylserine-induced inhibition of DNA synthesis in blood mononuclear cells

1992 ◽  
Vol 24 (3) ◽  
pp. 191-201 ◽  
Author(s):  
Elisabeth Caselli ◽  
Fabrizio Bellini ◽  
Ponzin Diego ◽  
O.Roberto Baricordi ◽  
Alessandro Bruni
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Dna Synthesis ◽  
Mononuclear Cells ◽  
Kinase C ◽  
Blood Mononuclear Cells ◽  
Inhibition Of Dna Synthesis
Sign in / Sign up

Export Citation Format

Share Document