Somatomedin, Transferrin and Amino-Acids in Serum Following Injection of Human Growth Hormone in Children with Growth Disease

1984 ◽  
Vol 16 (10) ◽  
pp. 539-543 ◽  
Author(s):  
A. Repellin ◽  
R. Schimpff ◽  
P. Georges ◽  
J. Job
Keyword(s):  
Amino Acids ◽  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth

Effects of Insulin-Like Growth Factor-1 and Growth Hormone on the Net Flux of Amino Acids across the Hind Limbs in the Surgically Traumatized Pig

1995 ◽  
Vol 88 (3) ◽  
pp. 285-292 ◽  
Author(s):  
Kjell Malmlöf ◽  
Zuzana Cortova ◽  
Henri Saxerholt ◽  
Eivor Karlsson ◽  
Vibeke Arrhenius-Nyberg ◽  
...  
Keyword(s):  
Amino Acids ◽  
Growth Hormone ◽  
Growth Factor ◽  
Human Insulin ◽  
Human Growth Hormone ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Insulin Like Growth Factor ◽  
Recombinant Human Insulin ◽  
Hind Limbs

1. After surgery three groups of six female pigs weighing on average 52.2 kg (SD 3.5) received vehicle, recombinant insulin-like factor-1 (364.4 μg day−1 kg−1) or recombinant human growth hormone (467.7 m-i.u. day−1 kg−1) for two post-operative days. Vehicle and peptides were infused intravenously together with total parenteral nutrition providing 129 kJ day−1 kg−1 non-protein calories and 0.35 gN day−1 kg−1. 2. On both post-operative days the mean concentration of insulin-like growth factor-1 in arterial blood samples was clearly below presurgical levels in animals receiving vehicle or recombinant human growth hormone, whereas recombinant human insulin-like growth factor-1 infusions more than restored insulin-like growth factor-1 concentrations. These last samples, however, contained significantly (P<0.05) less insulin than those from other animals. 3. Infusion of recombinant human growth factor was often associated with higher circulating levels of amino acids compared with recombinant human insulin-like growth factor-1 infusions. Despite this, both hormones significantly (P < 0.05) increased the hind limb net balance of total amino acids on postoperative day 1. Net balances of −44.2, +69.5 and +100.9 μmol/min (pooled SE 35.3) were associated with infusion of vehicle, recombinant human insulinlike growth factor-1 and recombinant human growth hormone respectively. This response was also closely reflected in the group of non-essential amino acids. 4. The net efflux of alanine from the hind limbs was also significantly (P < 0.002) reduced, whereas glutamine was less affected. 5. On post-operative day 2, there was a general drop in cortisol and urea levels, implying a loss of catabolic tone. Concomitantly, most effects seen on amino acids flux after hormone administration on the previous day disappeared. 6. It is concluded that, in the acute catabolic state, both recombinant human insulin-like growth factor-1 and recombinant human growth hormone can prevent the erosion of body protein by increasing the peripheral net balance of amino acids and can thus increase the efficacy of total parenteral nutrition.

INFLUENCE OF HUMAN GROWTH HORMONE (HGH) ON PLASMA AND URINE AMINO ACID CONCENTRATIONS IN HYPOPITUITARY DWARFS

1969 ◽  
Vol 62 (3) ◽  
pp. 513-520 ◽  
Author(s):  
M Zachmann
Keyword(s):  
Amino Acids ◽  
Growth Hormone ◽  
Amino Acid ◽  
Human Growth Hormone ◽  
Plasma Concentrations ◽  
Human Growth ◽  
Plasma Amino Acids ◽  
Before And After ◽  
Urinary Amino Acids ◽  
Urinary Amino

ABSTRACT Amino acids in the plasma and urine of 6 hypopituitary dwarfs before and after 3–5 days of human growth hormone (HGH) administration (2 mg/m2 daily) were studied. As reported previously, the concentrations of several amino acids in the plasma of untreated hypopituitary dwarfs are low. After administration of HGH certain amino acids in the plasma increased regularly (threonine, serine, glycine, methionine and others) and the overall amino acid pattern in the plasma became normal. Other amino acids did not show consistent changes. The changes in the plasma concentrations do not seem to be related to renal mechanisms, since urinary amino acids and amino acid clearances varied only little. The HGH induced increase of plasma amino acids affects different amino acids than those involved in the increase of plasma amino acids induced by puberty in the male. This suggests that HGH and testosterone have different effects on the amino acid metabolism.

LONG-TERM EFFECTS OF HUMAN GROWTH HORMONE ON PLASMA AMINO ACIDS TRANSPORT IN HYPOPITUITARY DWARFISM

1979 ◽  
Vol 92 (3) ◽  
pp. 398-406 ◽  
Author(s):  
Tamotu Sato ◽  
Yasuko Uchigata
Keyword(s):  
Amino Acids ◽  
Growth Hormone ◽  
Human Growth Hormone ◽  
Aromatic Amino Acids ◽  
Human Growth ◽  
Prolonged Treatment ◽  
Plasma Amino Acids ◽  
Long Term Effects ◽  
Gh Therapy ◽  
Normal Children

ABSTRACT The chronic effects of human growth hormone (hGH) on the transport of plasma amino acids (PAA) induced by glucose administration were studied in 17 patients with GH deficiency at different stages in the course of GH therapy. The study comprised 9 patients before and after 2–3 months of the therapy and 8 patients after prolonged treatment of 2–3 years. Five normal children served as controls. Analysis of 13 neutral and acidic PAA concentrations before and 2 h after glucose loading was carried out, and a decrease in PAA was expressed as a percentage of 2 h value to the initial level (PAA ratio). Fasting levels of several PAA before treatment were significantly lower than those of controls which gradually rose during the course of the therapy. The mean ± sd value of PAA ratio was also reduced before treatment (68 ± 16 %) vs. that of controls (82 ± 16 %, P < 0.05), which rose after 2–3 months of GH therapy to a comparable level of controls (91 ± 26 %). In patients treated for 2–3 years, however, PAA ratio was decreased to the level of pre-treatment (57 ± 17 %), P < 0.01 vs. control). These changes were pronounced in glucogenic, branched-chain and aromatic amino acids. Serum gamma-glutamyltranspeptidase (GGTP) activity was also low before GH therapy and normalized by the treatment. However, no significant correlation was noted between PAA ratio and serum GGTP activity or GH level. These results indicate that PAA transport evoked by endogenous insulin changes considerably according to the duration of GH therapy, and this may reflect a peripheral alteration of responsiveness to exogenous GH in the prolonged course of GH therapy in pituitary dwarfs.

Hyperglycemic action of synthetic C-terminal fragments of human growth hormone.

1978 ◽  
Vol 234 (5) ◽  
pp. E521
Author(s):  
F M Ng ◽  
J Bornstein
Keyword(s):  
Amino Acids ◽  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Biologically Active ◽  
Active Peptides ◽  
Intravenous Insulin ◽  
Insulin Tolerance ◽  
In Vivo Effects

The synthetic peptides corresponding to amino acids 172-191, 176-191, 177-191, 178-191, 179-191, and 180-191 of human growth hormone (hGH) have been studied for their in vivo effects in normal rats. Four of the peptides (hGH 172-191, 176-191, 177-191, and 178-191) produced a short-lived rise in blood glucose and a more sustained rise in plasma insulin, whereas the other two (hGH 179-191 and 180-191) were inert in the systems tested. A single dose (5 nmol/kg body wt) of the peptides containing the amino acids sequence 178-191 of the hGH molecule significantly reduced insulin sensitivity of the animals in intravenous insulin tolerance tests. The findings also indicate that the biologically active peptides must not only have the minimum of the informational sequence but also that this must be in correct physical configuration.

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