Proportional Dose-Response Relationship and Lower Within-Patient Variability of Insulin Detemir and NPH Insulin in Subjects With Type 1 Diabetes Mellitus

2007 ◽  
Vol 115 (07) ◽  
pp. 461-467 ◽  
Author(s):  
A. Wutte ◽  
J. Plank ◽  
M. Bodenlenz ◽  
C. Magnes ◽  
W. Regittnig ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Dose Response ◽  
Insulin Detemir ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Nph Insulin

Treatment with insulin detemir or NPH insulin in children aged 2-5 yr with type 1 diabetes mellitus

2011 ◽  
Vol 12 (7) ◽  
pp. 632-641 ◽  
Author(s):  
Nandu Thalange ◽  
Abdullah Bereket ◽  
Jens Larsen ◽  
Line Conradsen Hiort ◽  
Valentina Peterkova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Insulin Detemir ◽  
Nph Insulin

scholarly journals Quality of Life of Patients with Type 1 Diabetes Mellitus Using Insulin Analog Glargine Compared with NPH Insulin: A Systematic Review and Policy Implications

2018 ◽  
Vol 11 (4) ◽  
pp. 377-389 ◽  
Author(s):  
Paulo H. R. F. Almeida ◽  
Thales B. C. Silva ◽  
Francisco de Assis Acurcio ◽  
Augusto A. Guerra Júnior ◽  
Vania E. Araújo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Policy Implications ◽  
Insulin Analog ◽  
Nph Insulin

scholarly journals Dose-Response Relationship of Insulin Glulisine in Subjects With Type 1 Diabetes

Diabetes Care ◽  
2007 ◽  
Vol 30 (10) ◽  
pp. 2506-2507 ◽  
Author(s):  
R. H.A. Becker ◽  
A. D. Frick ◽  
L. Nosek ◽  
L. Heinemann ◽  
K. Rave
Keyword(s):  
Type 1 Diabetes ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Insulin Glulisine ◽  
Relationship Of

scholarly journals A dose–response meta-analysis between serum concentration of 25-hydroxy vitamin D and risk of type 1 diabetes mellitus

2020 ◽  
Author(s):  
Yilin Hou ◽  
An Song ◽  
Yuxin Jin ◽  
Qiuyang Xia ◽  
Guangyao Song ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Dose Response ◽  
Meta Analysis ◽  
Cochrane Library ◽  
25 Hydroxy Vitamin D ◽  
Meta Regression

AbstractIt remains debatable whether vitamin D plays any role as a risk factor for type 1 diabetes mellitus (T1DM). We have summarized the effect of circulating 25-hydroxy vitamin D [25(OH)D] concentration on the risk of developing T1DM via a dose–response meta-analysis. We undertook a database search on PubMed, Embase, and Cochrane Library from inception to January 2020. A meta-analysis based on random-effects model was applied. Subgroup analysis and meta-regression were performed to inspect the source of heterogeneity. Dose–response data were examined using the generalized least squares trend estimation method. This study was registered with the PROSPERO (ID: CRD42020166174). In total, 16 studies including 10,605 participants (3913 case patients) were included. The pooled odds ratios (OR) and 95% confidence intervals (95% CI) for the highest versus the lowest 25(OH)D concentration was 0.39 (0.27, 0.57), with a high heterogeneity (I2 = 76.7%, P < 0.001). Meta-regression analysis identified latitude (P = 0.02), adjustment for gender (P = 0.001), and 25(OH)D stratification (P < 0.001) as sources of heterogeneity. Furthermore, the nonlinear dose–response analysis determined the OR (95% CI) of T1DM to be 0.91 (0.90, 0.93) per 10 nmol/L increase in the 25(OH)D concentration. A ‘U’-shaped association was found between serum 25(OH)D concentration and risk of T1DM. The present study highlights the significant inverse association between the circulating 25(OH)D concentration and the risk of T1DM.

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