Cardiomyogenic Potential of Human Adult Bone Marrow Mesenchymal Stem Cells in Vitro

2008 ◽  
Vol 56 (2) ◽  
pp. 77-82 ◽  
Author(s):  
P. Antonitsis ◽  
E. Ioannidou-Papagiannaki ◽  
A. Kaidoglou ◽  
N. Charokopos ◽  
A. Kalogeridis ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adult Bone Marrow ◽  
Human Adult ◽  
Marrow Mesenchymal Stem Cells ◽  
Adult Bone

scholarly journals Human Adult Bone Marrow Mesenchymal Stem Cells Repair Experimental Conduction Block in Rat Cardiomyocyte Cultures

2005 ◽  
Vol 46 (10) ◽  
pp. 1943-1952 ◽  
Author(s):  
Saskia L.M.A. Beeres ◽  
Douwe E. Atsma ◽  
Arnoud van der Laarse ◽  
Daniël A. Pijnappels ◽  
John van Tuyn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Conduction Block ◽  
Adult Bone Marrow ◽  
Human Adult ◽  
Marrow Mesenchymal Stem Cells ◽  
Adult Bone

Temporal HLA profiling and immunomodulatory effects of human adult bone marrow- and adipose-derived mesenchymal stem cells

2014 ◽  
Vol 9 (1) ◽  
pp. 67-79 ◽  
Author(s):  
Bhamini Purandare ◽  
Takele Teklemariam ◽  
Longmei Zhao ◽  
Basil M Hantash
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Immunomodulatory Effects ◽  
Adult Bone Marrow ◽  
Human Adult ◽  
Adult Bone

Induction of mice adult bone marrow mesenchymal stem cells into functional motor neuron-like cells

2016 ◽  
Vol 77 ◽  
pp. 129-142 ◽  
Author(s):  
Rafal H. Abdullah ◽  
Nahi Y. Yaseen ◽  
Shahlaa M Salih ◽  
Ahmad Adnan Al-Juboory ◽  
Ayman Hassan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Motor Neuron ◽  
Adult Bone Marrow ◽  
Marrow Mesenchymal Stem Cells ◽  
Adult Bone

scholarly journals Heparan Sulfate Enhances the Self-Renewal and Therapeutic Potential of Mesenchymal Stem Cells from Human Adult Bone Marrow

2012 ◽  
Vol 21 (11) ◽  
pp. 1897-1910 ◽  
Author(s):  
Torben Helledie ◽  
Christian Dombrowski ◽  
Bina Rai ◽  
Zophia X.H. Lim ◽  
Ian Lee Hock Hin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Heparan Sulfate ◽  
Therapeutic Potential ◽  
The Self ◽  
Self Renewal ◽  
Adult Bone Marrow ◽  
Human Adult ◽  
Adult Bone

scholarly journals Trichostatin A-Mediated Epigenetic Transformation of Adult Bone Marrow-Derived Mesenchymal Stem Cells Biases theIn VitroDevelopmental Capability, Quality, and Pluripotency Extent of Porcine Cloned Embryos

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Marcin Samiec ◽  
Jolanta Opiela ◽  
Daniel Lipiński ◽  
Joanna Romanek
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Histone Deacetylases ◽  
Trichostatin A ◽  
Adult Bone Marrow ◽  
Gene Transcripts ◽  
Adult Bone

The current research was conducted to explore thein vitrodevelopmental outcome and cytological/molecular quality of porcine nuclear-transferred (NT) embryos reconstituted with adult bone marrow-derived mesenchymal stem cells (ABM-MSCs) that were epigenetically transformed by treatment with nonspecific inhibitor of histone deacetylases, known as trichostatin A (TSA). The cytological quality of cloned blastocysts was assessed by estimation of the total cells number (TCN) and apoptotic index. Their molecular quality was evaluated by real-time PCR-mediated quantification of gene transcripts for pluripotency- and multipotent stemness-related markers (Oct4, Nanog, andNestin). The morula and blastocyst formation rates of NT embryos derived from ABM-MSCs undergoing TSA treatment were significantly higher than in the TSA-unexposed group. Moreover, the NT blastocysts generated using TSA-treated ABM-MSCs exhibited significantly higher TCN and increased pluripotency extent measured with relative abundance ofOct4andNanogmRNAs as compared to the TSA-untreated group. Altogether, the improvements in morula/blastocyst yields and quality of cloned pig embryos seem to arise from enhanced abilities for promotion of correct epigenetic reprogramming of TSA-exposed ABM-MSC nuclei in a cytoplasm of reconstructed oocytes. To our knowledge, we are the first to report the successful production of mammalian high-quality NT blastocysts using TSA-dependent epigenomic modulation of ABM-MSCs.

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