Autism is both a medical condition that can give rise to disability and an example of human neurological variation (‘neurodiversity’) that contributes to identity, with cognitive assets and challenges. We refer to this as the dual nature of autism. Enhancing adaptation and wellbeing is the ultimate goal for intervention/support. Evidence-based support for autistic people across the lifespan is emerging. Support should be collaborative between autistic individuals, their families, and service providers, taking a shared decision-making approach. To maximize the individual’s potential, comprehensive early intervention and parent-mediated intervention, ideally taking a naturalistic approach, may help support the early development of adaptive, cognitive and language skills. Targeted intervention of social skills and aspects of cognition may help but challenges remain for behavioural flexibility and generalisation to different contexts. To minimize barriers for an individual’s development and adaptation, augmentative and alternative communication may potentially reduce communication difficulties. Alleviating co-occurring health challenges by timely medical, pharmacological or psychological interventions is essential. Finally, optimizing the person-environment fit by creating autism-friendly contexts through reasonable adjustments is critical. This involves supporting families, reducing stigma, enhancing peer understanding of autism, and promoting true inclusion in education, community and work environments, alongside strong advocacy.