Bibliographical Notices Outlines of Physiology, Human and Comparative . By John Marshall, F.R.S., Professor of Surgery in University College, London; Surgeon to the University College Hospital. With additions by Francis G. Smith, M.D., Professor of the Institutes of Medicine in the University of Pennsylvania. Philadelphia: Henry C. Lea. 1868. 8vo. pp. 1026.

1868 ◽  
Vol 79 (16) ◽  
pp. 248-249
Keyword(s):  
University Of Pennsylvania ◽  
College Hospital ◽  
University College ◽  
University College London ◽  
The University ◽  
John Marshall

The life and death of laboratory teaching of medical physiology: a personal narrative. Part I.

1993 ◽  
Vol 264 (6) ◽  
pp. S16 ◽  
Author(s):  
H W Davenport
Keyword(s):  
Personal Narrative ◽  
Human Subjects ◽  
University Of Pennsylvania ◽  
Laboratory Course ◽  
Life And Death ◽  
University College ◽  
History Of ◽  
University College London ◽  
Laboratory Teaching ◽  
The University

Part I of this essay sketches the history of laboratory teaching of medical physiology in England from the perspective of the author as a student at Oxford from 1935 to 1938. The systematic laboratory teaching that began in the 1870s at University College London under William Sharpey was carried to Oxford, as well as to other English and Scottish universities, by Sharpey's junior colleagues. C. S. Sherrington added mammalian experiments, and C. G. Douglas and J. G. Priestley added experiments on human subjects. The author describes his experience as a student in the Oxford courses and tells how he learned physiology by teaching it from 1941 to 1943 in the laboratory course established at the University of Pennsylvania by Oxford-trained physiologist Cuthbert Bazett.

Establishing Arrays of Stereogenic Centers: The Sato/Chida Synthesis of (-)-Kainic Acid

2013 ◽  
Author(s):  
Douglass F. Taber
Keyword(s):  
Catalyst System ◽  
Allylic Alcohol ◽  
University Of Pennsylvania ◽  
Ni Catalyst ◽  
Max Planck ◽  
Stereogenic Centers ◽  
University College London ◽  
Enantioselective Addition ◽  
La Jolla ◽  
The University

Benjamin List of the Max-Planck-Institut, Mülheim, devised (J. Am. Chem. Soc. 2010, 132, 10227) a catalyst system for the stereocontrolled epoxidation of a trisubstituted alkenyl aldehyde 1. Takashi Ooi of Nagoya University effected (Angew. Chem. Int. Ed. 2010, 49, 7562; see also Org. Lett. 2010, 12, 4070) enantioselective Henry addition to an alkynyl aldehyde 3. Madeleine M. Joullié of the University of Pennsylvania showed (Org. Lett. 2010, 12, 4244) that an amine 7 added selectively to an alkynyl aziridine 6. Yutaka Ukaji and Katsuhiko Inomata of Kanazawa University developed (Chem. Lett. 2010, 39, 1036) the enantioselective dipolar cycloaddition of 9 with 10. K. C. Nicolaou of Scripps/La Jolla observed (Angew. Chem. Int. Ed. 2010, 49, 5875; see also J. Org. Chem. 2010, 75, 8658) that the allylic alcohol from enantioselective reduction of 12 could be hydrogenated with high diastereocontrol. Masamichi Ogasawara and Tamotsu Takahashi of Hokkaido University added (Org. Lett. 2010, 12, 5736) the allene 14 to the acetal 15 with substantial stereocontrol. Helen C. Hailes of University College London investigated (Chem. Comm. 2010, 46, 7608) the enzyme-mediated addition of 18 to racemic 17. Dawei Ma of the Shanghai Institute of Organic Chemistry, in the course of a synthesis of oseltamivir (Tamiflu), accomplished (Angew. Chem. Int. Ed. 2010, 49, 4656) the enantioselective addition of 21 to 20. Shigeki Matsunaga of the University of Tokyo and Masakatsu Shibasaki of the Institute of Microbial Chemistry developed (Org. Lett. 2010, 12, 3246) a Ni catalyst for the enantioselective addition of 23 to 24. Juthanat Kaeobamrung and Jeffrey W. Bode of ETH-Zurich and Marisa C. Kozlowski of the University of Pennsylvania devised (Proc. Natl. Acad. Sci. 2010, 107, 20661) an organocatalyst for the enantioselective addition of 27 to 26. Yihua Zhang of China Pharmaceutical University and Professor Ma effected (Tetrahedron Lett. 2010, 51, 3827) the related addition of 27 to 29. There have been scattered reports on the stereochemical course of the coupling of cyclic secondary organometallics. In a detailed study, Paul Knochel of Ludwig-Maximilians- Universität München showed (Nat. Chem. 2020, 2, 125) that equatorial bond formation dominated, exemplified by the conversion of 31 to 33.

THUR 037 Identification of biofluid markers of TDP-43 pathology

2018 ◽  
Vol 89 (10) ◽  
pp. A5.4-A6
Author(s):  
Shafei Rachelle ◽  
Foiani Martha ◽  
Heller Carolin ◽  
Heslegrave Amanda ◽  
Woollacott Ione ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Frontotemporal Dementia ◽  
Observational Studies ◽  
Healthy Controls ◽  
The Novel ◽  
Healthy Individuals ◽  
University College ◽  
University College London ◽  
The Mean ◽  
The University

IntroductionFrontotemporal dementia (FTD) is usually caused pathologically by either tau or TDP-43. Previous biofluid assays of TDP-43 have not so far proved to be sensitive or specific for identifying those cases with TDP-43 pathology.Material and methodsWe set out to investigate the novel TDP-43 Simoa assay (Quanterix) assay in both plasma and CSF in a cohort of patients recruited from the University College London FTD observational studies with known or likely TDP-43 pathology (17), non-TDP-43 pathology (13), and healthy controls (10).ResultsThe mean [standard deviation] plasma TDP-43 concentration was higher in those with likely TDP-43 pathology (155.1 [223.4] pg/ml) than those with non-TDP pathology (112.39 [252.9] pg/ml), and healthy controls (50.0 [23.1] pg/ml), but the differences between groups was non-significant, with substantial overlap in concentrations between all three groups. The mean CSF TDP-43 concentration was 2.9 [0.3] pg/ml in those with likely TDP-43 pathology, 2.8 [0.4] pg/ml in those with non-TDP pathology, and 3.1 [0.5] pg/ml in healthy controls. DiscussionThe assay tested in this study does not accurately distinguish between those with likely TDP-43 pathology and either disease controls or healthy individuals. There remains an urgent need to develop a better biofluid assay for pathological TDP-43.

Sign in / Sign up

Export Citation Format

Share Document