Urinary Excretion of the Serotonin Metabolite, 5-Hydroxyindoleacetic Acid, in Various Clinical Conditions

1956 ◽  
Vol 255 (6) ◽  
pp. 270-272 ◽  
Author(s):  
Bernard J. Haverbagk ◽  
Albert Sjoerdsma ◽  
Luther L. Terry
Keyword(s):  
Urinary Excretion ◽  
Hydroxyindoleacetic Acid ◽  
Clinical Conditions

Urinary 5-HIAA Excretion is not Increased in Patients with Head and Neck Paragangliomas

2012 ◽  
Vol 27 (2) ◽  
pp. 160-163 ◽  
Author(s):  
Leonie T. Van Hulsteijn ◽  
Nicolette Van Duinen ◽  
Johannes A. Romijn ◽  
Johannes W.A. Smit ◽  
Eleonora P.M. Corssmit
Keyword(s):  
Urinary Excretion ◽  
Head And Neck ◽  
Reference Range ◽  
Excretion Rate ◽  
Case Reports ◽  
Catecholamine Excess ◽  
Hydroxyindoleacetic Acid ◽  
Excretion Rates ◽  
Almost All ◽  
Head And Neck Paragangliomas

Background Case reports have documented carcinoid-like features in head and neck paragangliomas (HNPGLs), which, in addition to catecholamine storing granules, may also contain granules with serotonin. Serotonin is metabolized to 5-hydroxyindoleacetic acid (5-HIAA). Aim To assess the urinary excretion rates of 5-HIAA and catecholamines in HNPGL patients. Methods In 114 consecutive HNPGL patients, normetanephrine, metanephrine, norepinephrine, epinephrine, VMA, dopamine, 3-methoxytyramine and 5-HIAA excretion rates were measured in two 24-hour urinary samples. Increased excretion rates were defined as an increase of the average hormone excretion rate of 2 urine samples above the reference range. In all patients with catecholamine excess, intrathoracic and abdominal paragangliomas were excluded by 123I-MIBG scintigraphy, MRI and/or CT. Genetic screening for mutations in genes of the succinate dehydrogenase (SDH) family was performed. Results Mean urinary 5-HIAA excretion rate was 14±9 μmol/24 hours (reference range 10–44 μmol/24 hours). Urinary 5-HIAA excretion was slightly increased in only 1 patient (48 μmol/24 hours). None of the 50 patients (44%) with increased urinary excretion rates of catecholamines and/or their metabolites had elevated 5-HIAA excretion. Conclusion Urinary 5-HIAA excretion is within the normal reference range in almost all HNPGL patients. Therefore, this parameter has no clinical relevance in the routine clinical assessment of HNPGL patients.

Serotonin Metabolism in Chronic Tension-Type Headache

Cephalalgia ◽  
1997 ◽  
Vol 17 (8) ◽  
pp. 843-848 ◽  
Author(s):  
L Bendtsen ◽  
R Jensen ◽  
I Hindberg ◽  
S Gammeltoft ◽  
J Olesen
Keyword(s):  
Urinary Excretion ◽  
Tension Type Headache ◽  
Serotonin Level ◽  
Healthy Controls ◽  
Serotonin Metabolism ◽  
Serotonergic Neurons ◽  
Chronic Tension Type Headache ◽  
Hydroxyindoleacetic Acid ◽  
Type Headache

Serotonergic neurons play a major role in the regulation of pain and may therefore also be involved in the pathophysiology of tension-type headache. Platelets are important in the regulation of the free serotonin level in plasma and may be a model of serotonergic neurons. The aim of the present study was to investigate the peripheral serotonin (5HT) metabolism in patients with chronic tension-type headache. The 5HT levels in platelets and in plasma, the beta-thromboglobulin (ß-TG) levels in plasma, and the urinary excretion of 5-hydroxyindoleacetic acid (5HIAA) were measured in 40 patients with chronic tension-type headache and in 40 healthy controls. The platelet uptake index was calculated as the ratio between platelet 5HT and plasma 5HT levels. There were, no significant differences in platelet 5HT, plasma 5HT ß-TG, or 5HIAA between patients and controls. The platelet uptake index was significantly lower in patients 243 (136-367) than in controls 352 (202-508), p=0.03. Our results indicate that the peripheral 5HT metabolism is largely normal in patients with chronic tension-type headache.

Urinary excretion of indolic compounds in rats with intestinal pouches

1961 ◽  
Vol 200 (4) ◽  
pp. 794-796 ◽  
Author(s):  
Robert M. Donaldson ◽  
Horacio A. Dolcini ◽  
Seymour J. Gray
Keyword(s):  
Small Intestine ◽  
Oral Administration ◽  
Urinary Excretion ◽  
Indoleacetic Acid ◽  
Bacterial Activity ◽  
Acid Excretion ◽  
Indole Compounds ◽  
Indolic Compounds ◽  
Hydroxyindoleacetic Acid ◽  
The Creation

The urinary excretion of indican and of free and total indoleacetic acid is significantly increased in the rat in the presence of a localized area of intestinal stasis produced surgically by the creation of a pouch in the small intestine. Tryptamine, serotonin and 5-hydroxyindoleacetic acid excretion in the urine is not altered. Evidence that intestinal stasis and bacterial activity within the pouch are responsible for the increased amounts of indican and indoleacetic acid in the urine is supported by the facts that a) indole compounds are not increased in the urine when the intestinal pouch is formed so that peristalsis keeps it empty, b) removal of the intestinal pouch results in a reduction of indican and indoleacetic acid to normal levels within 24 hours and c) oral administration of neomycin promptly reduces the excretion of these compounds to normal levels.

Acidic Catecholamine Metabolites and 5-Hydroxyindoleacetic Acid in Urine: The Influence of Diet

1996 ◽  
Vol 33 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Fumiko Mashige ◽  
Yoshikazu Matsushima ◽  
Hideko Kanazawa ◽  
Ichiro Sakuma ◽  
Nobuharù Takai ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Diurnal Variation ◽  
Healthy Subjects ◽  
Reference Value ◽  
Reference Ranges ◽  
Vanillylmandelic Acid ◽  
Electrochemical Detector ◽  
Anion Exchange Column ◽  
Kiwi Fruit ◽  
Hydroxyindoleacetic Acid

Concentrations of vanillylmandelic acid (VMA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), vanillic acid (VA) and 5-hydroxyindoleacetic acid (5-HIAA) in urine from healthy subjects were determined by a high-performance liquid chromatography system with a mixed-mode (C18/ anion-exchange) column and an 8-channel electrochemical detector, in order to study the influence of diet, diurnal variation and age. The urinary excretion of 5-HIAA increased significantly after eating banana, pineapple, tomato, kiwi fruit and walnut. An increase in the urinary excretion of DOPAC and HVA after eating banana and that of VA after taking vanilla was also noted. The urinary excretion of VMA was not significantly influenced by any of the foods examined. The urinary excretion of 5-HIAA in the first-morning urine increased beyond the upper limit of the reference value when banana was taken at 2000 h the previous day. The excretion of all metabolites in the second-morning urine in the fasting state was within respective reference ranges. Diurnal variation of the excretion of VMA, DOPAC, HVA and 5-HIAA in urine was relatively small, but that of VA was large. The concentrations (mmol/mol creatinine) of VMA, DOPAC, HVA, 5-HIAA and VA in the first-morning urine from healthy subjects increased from 7 days after birth to 1 year and then decreased to adult levels at 13 years of age.

Banana Feeding and Urinary Excretion of 5—Hydroxyindoleacetic Acid

PEDIATRICS ◽  
1958 ◽  
Vol 21 (6) ◽  
pp. 884-884
Keyword(s):  
Urinary Excretion ◽  
Marked Reduction ◽  
Intestinal Tract ◽  
Fold Increase ◽  
Experimental Period ◽  
Diagnostic Error ◽  
Carcinoid Tumors ◽  
Experimental Diet ◽  
Striking Increase ◽  
Hydroxyindoleacetic Acid

It was accidentally observed that monkeys receiving a diet which included a banana on the final day of an experimental period suddenly excreted a many-fold increase of 5-hydroxyindoleacetic acid (5-HIAA) in the 24-hour urine collection corresponding to the addition of the banana to the experimental diet. This chance observation was consistently confirmed, and it was found that feeding of 50 to 150 gm of banana resulted in 5 to 30 times as much excretion of 5-HIAA as was excreted in control periods when banana was not included in the diet. Aside from intrinsic interest, this observation is of importance because heretofore increased excretion of 5-HIAA has been observed in the urine of patients with carcinoid tumors and in no other clinical condition in man. No previous reports have shown any influence of dietary constituents other than tryptophan in producing such a striking increase in excretion of 5-HIAA. Administration of iproniazid resulted in a marked reduction in the excretion of 5-HIAA by monkeys being fed banana, just as it does in the case of excretion of 5-HIAA in the urine of patients with carcinoid tumors. At the time of this preliminary report, the ingredient in banana responsible for the increased urinary excretion of 5-HIAA had not been identified, but it is not tryptophan. Elimination of bacteria from the intestinal tract by means of neomycin did not influence the excretion of 5-HIAA in monkeys due to banana in the diet. The effect of banana in the diet on urinary excretion of 5-HIAA was confirmed in two children. This phenomenon is not apt to lead to diagnostic error in children, in whom carcinoid tumors have not been reported, but the importance of application of these findings to diagnosis of carcinoid tumors in adults is apparent.

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