Application of Synchrotron Radiation Imaging for Non-destructive Monitoring of Mouse Rheumatoid Arthritis Model

Periploca forrestii Schltr ( P. forrestii) is a herb used in traditional Chinese medicine for its anti-rheumatoid arthritis effect. The aim of this study was to compare the pharmacokinetic properties of the 5 active components of this plant: neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid C, and periplocin between normal rats and adjuvant-induced arthritis model rats. After the intravenous administration (177.78 mg/kg) of P. forrestii extract, samples were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. Compared with normal rats, the area under the curve [(AUC)(0-t), AUC(0-∞)], mean residence time [(MRT)(0-t), MRT(0-∞)] of neochlorogenic acid-treated rats decreased significantly, and drug clearance (CL) and apparent volume of distribution (V) increased significantly; the V of chlorogenic acid-treated rats decreased significantly, and MRT(0-t) significantly increased; the AUC(0-t) and AUC(0-∞) of cryptochlorogenic acid-treated rats decreased significantly, and CL and V increased significantly; the AUC(0-t) and MRT(0-t) of isochlorogenic acid C-treated rats decreased significantly, and V increased significantly; the AUC(0-t) and AUC(0-∞) of periplocin-treated rats increased significantly, and MRT(0-t), MRT(0-∞), CL, and V decreased significantly in model rats. The disease condition of rheumatoid arthritis in rats had a significant effect on the in vivo pharmacokinetics of P. forrestii after the intravenous administration.

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Update On Synchrotron Radiation TXRF: New Results

MRS Proceedings ◽

10.1557/proc-524-245 ◽

1998 ◽

Vol 524 ◽

Cited By ~ 1

Author(s):

S. Brennan ◽

P. Pianetta ◽

S. Ghosh ◽

N. Takaura ◽

C. Wiemer ◽

...

Keyword(s):

Synchrotron Radiation ◽

Total Reflection ◽

Synchrotron Source ◽

X Ray ◽

Non Destructive

ABSTRACTSynchrotron-based total-reflection x-ray fluorescence(SR-TXRF) has been developed as a leading technique for measuring wafer cleanliness. It holds advantages over other techniques in that it is non-destructive and allows mapping of the surface. The highest sensitivity observed thus far is 3x108 atoms/cm 2 (- 3fg) for 1000 second count time. Several applications of SR-TXRF are presented which take advantage of the energy tunability of the synchrotron source or the mapping capability.

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Microcalcifications of Breast Tissue: Appearance on Synchrotron Radiation Imaging with 6-μm Resolution

American Journal of Roentgenology ◽

10.2214/ajr.07.2610 ◽

2008 ◽

Vol 190 (4) ◽

pp. W234-W236 ◽

Cited By ~ 6

Author(s):

Keiko Imamura ◽

Norishige Ehara ◽

Yoichi Inada ◽

Yoshihide Kanemaki ◽

Joji Okamoto ◽

...

Keyword(s):

Synchrotron Radiation ◽

Breast Tissue ◽

Radiation Imaging

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Microstructure Evolution of Ag/TiO2 Thin Film

Magnetochemistry ◽

10.3390/magnetochemistry7010014 ◽

2021 ◽

Vol 7 (1) ◽

pp. 14

Author(s):

Dewi Suriyani Che Halin ◽

Kamrosni Abdul Razak ◽

Mohd Arif Anuar Mohd Salleh ◽

Mohd Izrul Izwan Ramli ◽

Mohd Mustafa Al Bakri Abdullah ◽

...

Keyword(s):

Thin Film ◽

Thin Films ◽

Growth Rate ◽

Synchrotron Radiation ◽

Tio2 Thin Film ◽

Sol Gel ◽

Tio2 Thin Films ◽

Contact Mode ◽

X Ray ◽

Radiation Imaging

Ag/TiO2 thin films were prepared using the sol-gel spin coating method. The microstructural growth behaviors of the prepared Ag/TiO2 thin films were elucidated using real-time synchrotron radiation imaging, its structure was determined using grazing incidence X-ray diffraction (GIXRD), its morphology was imaged using the field emission scanning electron microscopy (FESEM), and its surface topography was examined using the atomic force microscope (AFM) in contact mode. The cubical shape was detected and identified as Ag, while the anatase, TiO2 thin film resembled a porous ring-like structure. It was found that each ring that coalesced and formed channels occurred at a low annealing temperature of 280 °C. The energy dispersive X-ray (EDX) result revealed a small amount of Ag presence in the Ag/TiO2 thin films. From the in-situ synchrotron radiation imaging, it was observed that as the annealing time increased, the growth of Ag/TiO2 also increased in terms of area and the number of junctions. The growth rate of Ag/TiO2 at 600 s was 47.26 µm2/s, and after 1200 s it decreased to 11.50 µm2/s and 11.55 µm2/s at 1800 s. Prolonged annealing will further decrease the growth rate to 5.94 µm2/s, 4.12 µm2/s and 4.86 µm2/s at 2400 s, 3000 s and 3600 s, respectively.

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Synchrotron radiation X-ray tomographic microscopy (SRXTM) of brachiopod shell interiors for taxonomy: Preliminary report

Geoloski anali Balkanskog poluostrva ◽

10.2298/gabp1071109m ◽

2010 ◽

pp. 109-117 ◽

Cited By ~ 6

Author(s):

Neda Motchurova-Dekova ◽

David Harper

Keyword(s):

Synchrotron Radiation ◽

Three Dimensional ◽

X Rays ◽

X Ray ◽

Fine Grained ◽

Internal Structures ◽

Efficient Alternative ◽

Micro Tomography ◽

Light Beams ◽

Non Destructive

Synchrotron radiation X-ray tomographic microscopy (SRXTM) is a non-destructive technique for the investigation and visualization of the internal features of solid opaque objects, which allows reconstruction of a complete three-dimensional image of internal structures by recording of the differences in the effects on the passage of waves of energy reacting with those structures. Contrary to X-rays, produced in a conventional X-ray tube, the intense synchrotron light beams are sharply focused like a laser beam. We report encouraging results from the use of SRXTM for purely taxonomic purposes in brachiopods: an attempt to find a non-destructive and more efficient alternative to serial sectioning and several other methods of dissection together with the non-destructive method of X-ray computerised micro-tomography. Two brachiopod samples were investigated using SRXTM. In ?Rhynchonella? flustracea it was possible to visualise the 3D shape of the crura and dental plates. In Terebratulina imbricata it was possible to reveal the form of the brachidium. It is encouraging that we have obtained such promising results using SRXTM with our very first two fortuitous samples, which had respectively fine-grained limestone and marl as infilling sediment, in contrast to the discouraging results communicated to us by some colleagues who have tested specimens with such infillings using X-ray micro-tomography. In future the holotypes, rare museum specimens or delicate Recent material may be preferentially subjected to this mode of analysis.

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