Automatic Control of Focal Trajectory and Intensity of Ultrasound Phased Arrays in Minimum-Time Delivery of Thermal Dose with Imposed Normal Tissue Constraints

2007 ◽  
Author(s):  
Ran Niu ◽  
Adam Blankespoor ◽  
Jeff Moellmer ◽  
Robert Roemer ◽  
Mikhail Skliar
Keyword(s):  
Automatic Control ◽  
Normal Tissue ◽  
Phased Arrays ◽  
Minimum Time ◽  
Thermal Dose

scholarly journals Minimum-Time Thermal Dose Control of Thermal Therapies

2005 ◽  
Vol 52 (2) ◽  
pp. 191-200 ◽  
Author(s):  
D. Arora ◽  
M. Skliar ◽  
R.B. Roemer
Keyword(s):  
Minimum Time ◽  
Thermal Dose ◽  
Thermal Therapies ◽  
Dose Control

Constrained Predictive Control of Thermal Therapies for Minimum-Time Delivery of Thermal Dose

2007 ◽  
Vol 15 (6) ◽  
pp. 1030-1037 ◽  
Author(s):  
Dhiraj Arora ◽  
Mikhail Skliar ◽  
Daniel Cooley ◽  
Robert B. Roemer
Keyword(s):  
Predictive Control ◽  
Minimum Time ◽  
Thermal Dose ◽  
Thermal Therapies

scholarly journals Monte Carlo Simulations of Heat Deposition During Photothermal Skin Cancer Therapy Using Nanoparticles

Biomolecules ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 343
Author(s):  
J. Charles G. Jeynes ◽  
Freddy Wordingham ◽  
Laura J. Moran ◽  
Alison Curnow ◽  
Tim J. Harries
Keyword(s):  
Monte Carlo ◽  
Skin Cancer ◽  
Monte Carlo Simulations ◽  
Photothermal Therapy ◽  
Normal Tissue ◽  
Heat Diffusion ◽  
Thermal Dose ◽  
Plasmonic Nanoparticle ◽  
Heat Deposition ◽  
Invaluable Tool

Photothermal therapy using nanoparticles is a promising new approach for the treatment of cancer. The principle is to utilise plasmonic nanoparticle light interaction for efficient heat conversion. However, there are many hurdles to overcome before it can be accepted in clinical practice. One issue is a current poor characterization of the thermal dose that is distributed over the tumour region and the surrounding normal tissue. Here, we use Monte Carlo simulations of photon radiative transfer through tissue and subsequent heat diffusion calculations, to model the spatial thermal dose in a skin cancer model. We validate our heat rise simulations against experimental data from the literature and estimate the concentration of nanorods in the tumor that are associated with the heat rise. We use the cumulative equivalent minutes at 43 °C (CEM43) metric to analyse the percentage cell kill across the tumour and the surrounding normal tissue. Overall, we show that computer simulations of photothermal therapy are an invaluable tool to fully characterize thermal dose within tumour and normal tissue.

Cardiac myocytes cultured on a basement membrane extract of the ehs tumor

1986 ◽  
Vol 44 ◽  
pp. 270-271
Author(s):  
L. Terracio ◽  
A. Dewey ◽  
K. Rubin ◽  
T.K. Borg
Keyword(s):  
Extracellular Matrix ◽  
Basement Membrane ◽  
Cardiac Myocytes ◽  
Normal Tissue ◽  
Cell Spreading ◽  
Collagen Iv ◽  
Basement Membrane Extract ◽  
Membrane Extract ◽  
Growth Development ◽  
Multicellular Organisms

The recognition and interaction of cells with the extracellular matrix (ECM) effects the normal physiology as well as the pathology of all multicellular organisms. These interactions have been shown to influence the growth, development, and maintenance of normal tissue function. In previous studies, we have shown that neonatal cardiac myocytes specifically interacts with a variety of ECM components including fibronectin, laminin, and collagens I, III and IV. Culturing neonatal myocytes on laminin and collagen IV induces an increased rate of both cell spreading and sarcomerogenesis.

192: Tubularized Urethral Replacement: What is the Maximum Distance for Normal Tissue Regeneration?

2004 ◽  
Vol 171 (4S) ◽  
pp. 51-51
Author(s):  
Roger E. De Filippo ◽  
Hans G. Pohl ◽  
James J. Yoo ◽  
Anthony Atala
Keyword(s):  
Tissue Regeneration ◽  
Normal Tissue ◽  
Maximum Distance

Phased Arrays for Radio Astronomy, Remote Sensing, and Satellite Communications

2018 ◽  
Author(s):  
Karl F. Warnick ◽  
Rob Maaskant ◽  
Marianna V. Ivashina ◽  
David B. Davidson ◽  
Brian D. Jeffs
Keyword(s):  
Remote Sensing ◽  
Radio Astronomy ◽  
Phased Arrays ◽  
Satellite Communications
Sign in / Sign up

Export Citation Format

Share Document