Effects of complement inactivation and IgG depletion on skin reactivity to autologous serum in chronic idiopathic urticaria

2000 ◽  
Vol 106 (3) ◽  
pp. 567-572 ◽  
Author(s):  
Umberto Fagiolo ◽  
Franz Kricek ◽  
Christine Ruf ◽  
Andrea Peserico ◽  
Alberto Amadori ◽  
...  
Keyword(s):  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Skin Reactivity

Inhibitory effect of heparin on skin reactivity to autologous serum in chronic idiopathic urticaria

1999 ◽  
Vol 103 (6) ◽  
pp. 1143-1147 ◽  
Author(s):  
Umberto Fagiolo ◽  
Mauro Cancian ◽  
Lorella Bertollo ◽  
Andrea Peserico ◽  
Alberto Amadori
Keyword(s):  
Inhibitory Effect ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Skin Reactivity

scholarly journals Clinical Outcome of Autologous Serum Therapy in Chronic Idiopathic Urticaria

2017 ◽  
Vol 15 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Dharmendra Karn ◽  
Shekhar KC
Keyword(s):  
Skin Prick Test ◽  
Chronic Urticaria ◽  
Statistical Significance ◽  
Cost Effective ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
P Value ◽  
Prick Test ◽  
H1 Antihistamines ◽  
Serum Therapy

Background: Quality of life in chronic idiopathic urticaria is hampered as efficacy of H1-antihistamines is limited. Autologous serum containing tolerance-generating anti-idiotype antibodies is a novel and cost-effective therapy. This study was conducted to evaluate the efficacy of autologous serum therapy (AST) among chronic urticaria patients with autologous skin prick test positive and negative status.Methods: Untreated 102 patients of chronic urticaria were enrolled in a non-randomized interventional study. Patients were categorized into two groups based on autologous serum skin prick test as test positive (ASST +) and test negative (ASST -). Patients were then treated with intramuscular injection of 0.05ml per kg body weight of autologous serum weekly for 10 weeks. Urticaria activity scoring (UAS) tool was used for quantification of the symptoms. Weekly recording of UAS (range: 0-42) was made before the therapy (baseline) and during the therapy for 10 weeks.Results: Significant improvement with AST in the mean UAS was noted from baseline to 10 weeks in both the group of patients (14.6 ± 6.3 and 10.2 ± 5.1 for ASST+ group; 16.9 ± 7.8 and 8.6 ± 4.8 for ASST- group; at baseline and 10 weeks, respectively (p-value for both <0.05)). However no statistical significance was found while comparing the efficacy of the therapy against ASST + and ASST - Groups (p-value > 0.05).Conclusions: Irrespective of autologous skin prick test results, autologous serum therapy showed significant improvement in patients with chornic idiopathic urticaria. AST can, thus, be an effective treatment modality for it.

scholarly journals Usefulness of the Autologous Serum Test for the Diagnosis of Chronic Idiopathic Urticaria

2014 ◽  
Vol 26 (5) ◽  
pp. 592 ◽  
Author(s):  
Öykü Marasoğlu Çelen ◽  
Zekayi Kutlubay ◽  
Ertuğrul H. Aydemir
Keyword(s):  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Serum Test

scholarly journals ANTIHISTAMINE THERAPY EFFICACY IN PATIENTS WITH CHRONIC IDIOPATHIC URTICARIA

2012 ◽  
Vol 9 (2) ◽  
pp. 13-18
Author(s):  
R N Golubchikova ◽  
I V Danilycheva
Keyword(s):  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Autoimmune Disorders ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Laboratory Findings ◽  
Background Estimation ◽  
Full Effect ◽  
Third Line ◽  
Negative Skin Test

Background. Estimation of efficacy of antihistamines in patients with various severity levels and various clinical and laboratory variants of chronic idiopathic urticaria (CIU) . Methods. The retrospective study of the anamnestic clinical laboratory findings in 196 patients with CIU was performed. Results. The frequency of patients with full effect of antihistamines was 69%, partial efficacy — 11%, lack of efficacy — 20%. Lack of efficacy was dominated in patients with severe course of the disease and the presence of clinical manifestations of autoimmune disorders, non-specific inflammation and / or signs of cutaneous vasculitis. The full effect of antihistamines was dominated in patients with mild to medium CIU, with a normal clinical blood count and with a negative skin test with autologous serum. Conclusion. Lack of efficacy of of antihistamines in patients with severe course of disease, signs of autoimmune disorders specify on others nonhistamine mediators in CIU pathogenesis and application of the second and third line therapy of CIU.

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