scholarly journals ANTIHISTAMINE THERAPY EFFICACY IN PATIENTS WITH CHRONIC IDIOPATHIC URTICARIA

2012 ◽  
Vol 9 (2) ◽  
pp. 13-18
Author(s):  
R N Golubchikova ◽  
I V Danilycheva
Keyword(s):  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Autoimmune Disorders ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
Laboratory Findings ◽  
Background Estimation ◽  
Full Effect ◽  
Third Line ◽  
Negative Skin Test

Background. Estimation of efficacy of antihistamines in patients with various severity levels and various clinical and laboratory variants of chronic idiopathic urticaria (CIU) . Methods. The retrospective study of the anamnestic clinical laboratory findings in 196 patients with CIU was performed. Results. The frequency of patients with full effect of antihistamines was 69%, partial efficacy — 11%, lack of efficacy — 20%. Lack of efficacy was dominated in patients with severe course of the disease and the presence of clinical manifestations of autoimmune disorders, non-specific inflammation and / or signs of cutaneous vasculitis. The full effect of antihistamines was dominated in patients with mild to medium CIU, with a normal clinical blood count and with a negative skin test with autologous serum. Conclusion. Lack of efficacy of of antihistamines in patients with severe course of disease, signs of autoimmune disorders specify on others nonhistamine mediators in CIU pathogenesis and application of the second and third line therapy of CIU.

scholarly journals DIAGNOSTIC VALUE OF TEST WITH AUTOLOGOUS SERUM IN PATIENTS WITH EXACERBATION OF CHRONIC IDIOPATHIC URTICARIA

2012 ◽  
Vol 9 (5) ◽  
pp. 26-30
Author(s):  
R N Golubchikova ◽  
I V Danilycheva
Keyword(s):  
Skin Test ◽  
Clinical Laboratory ◽  
Severe Disease ◽  
Diagnostic Value ◽  
Chronic Idiopathic Urticaria ◽  
Positive Skin Test ◽  
Autologous Serum ◽  
Thyroid Antibodies ◽  
Laboratory Findings ◽  
Positive Skin

Background. A comparative study of the severity of CIU, effectiveness of antihistamines and determination the frequency of patients with and without thyroid antibodies among patients with CIU in groups with different skin sensitivity to autologous serum. Methods. The retrospective study of the anamnestic clinical laboratory findings in patients with chronic idiopathic. Results. 46% of patients had a positive skin test with autologous serum. A positive skin test with autologous serum was dominated in patients with severe disease, the lack of efficacy of antihistamines, and patients with anti-thyroid antibodies.

scholarly journals Clinical Manifestations of Orbital Involvement in IgG4-Related Disease: A Retrospective Study of 573 Patients

2021 ◽  
Author(s):  
Linyang Gan ◽  
Xuan Luo ◽  
Yunyun Fei ◽  
Linyi Peng ◽  
Jiaxin Zhou ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Chinese Patients ◽  
Laboratory Findings ◽  
Male Predominance ◽  
Orbital Involvement ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Serum Igg4

Abstract Purpose: To investigate the clinical manifestations of orbital involvement in a large cohort of Chinese patients with IgG4-related disease (IgG4-RD). Methods: A total of 573 patients with IgG4-related disease were included. We described and compared the demographic, clinical, laboratory and histopathologic findings from 314 patients with IgG4-related ophthalmic disease (IgG4-ROD) and 259 with extra-ophthalmic IgG4-RD.Results: Male predominance was found significant in extra-ophthalmic IgG4-RD only. Patients with IgG4-ROD showed younger age at diagnosis and longer duration from onset till diagnosis. In patients with extra-ophthalmic IgG4-RD, the most commonly involved extra-ophthalmic organ was pancreas; while in IgG4-ROD patients, salivary gland was most frequently affected. Multivariate analysis exhibited IgG4-ROD was associated with allergy history, higher serum IgG4/IgG ratio, multiple organs involvement and sialoadenitis. Orbital images were reviewed in 173 (55.1%) IgG4-ROD patients. Fifty-one (29.5%) patients had multiple lesions. Lacrimal gland involvement was detected in 151 (87.3%) patients, followed by extraocular muscles (40, 23.1%), other orbital soft tissue (40, 23.1%) and trigeminal nerve (8, 4.6%). Biopsy was performed from various organs in 390 cases. A dense lymphoplasmacytic infiltration and fibrosis were the main feature in orbital specimens. Storiform fibrosis and obliterative phlebitis were absent in lacrimal gland.Conclusions: Lacrimal gland involvement was the most common orbital manifestation of IgG4-ROD. Patients with IgG4-ROD showed different characteristic in demographic, clinical, laboratory findings compared to patients with extra-ophthalmic IgG4-RD. These features might indicate potential differences in the pathogenesis of these two subgroups of IgG4-RD.

Larval toxocariasis and its clinical manifestation in childhood in the Slovak Republic

1999 ◽  
Vol 73 (4) ◽  
pp. 323-328 ◽  
Author(s):  
J. Kinčeková ◽  
K. Reiterová ◽  
P. Dubinský
Keyword(s):  
Clinical Laboratory ◽  
Slovak Republic ◽  
Clinical Manifestations ◽  
Admission Rate ◽  
Laboratory Findings ◽  
Risk Of Disease ◽  
Repeated Doses ◽  
Specific Igg ◽  
Routine Clinical Laboratory ◽  
Age Category

Results are presented of 90 children aged 1–15 years hospitalized with toxocariasis. Blood count analysis and laboratory examination were done by routine clinical laboratory methods. Anti-Toxocara antibodies were detected in the serum of patients using an ELISA method. Demographic analysis of the children's families exposed to the risk of disease allowed estimation of age-specific rates for clinical toxocariasis. The probability of toxocaral infection and the intensity of its clinical manifestations in children are determined by the epidemiology of this zoonosis and by the risk factors in the family. The presence of high titres of specific IgG antibodies in all age categories correlates with the clinical manifestations of toxocariasis. The highest admission rate is in the age categories of 3–5 years (43.3%) and 6–10 years (36.7%). Laboratory findings show that the most conspicuous changes occur in the age category 1–5 years. The high percentage of seropositive dog-keeping and puppy-breeding families and the possibility of infection with repeated doses of larvae stimulate eosinophilia, which prevails in children under the age of five years. We present the percentage of patients whose parameters showed deviations from the reference values for a particular age category. Analyses of laboratory indices and of clinical manifestations will contribute to the accuracy of diagnosis and effectiveness of treatment of this disease.

scholarly journals Fluctuating neurological symptoms: should I call the neurologist or the hematologist?

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Rita Losa-Rodríguez ◽  
Carmen Pérez Martínez ◽  
Gabriel Rodríguez Pérez ◽  
Ignacio de la Fuente Graciani ◽  
Lara M. Gómez García
Keyword(s):  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Facial Asymmetry ◽  
Peripheral Blood Smear ◽  
Hematologic Disease ◽  
Early Administration ◽  
Laboratory Findings ◽  
Case Presentation ◽  
Elevated Creatinine

AbstractObjectivesThe objective of this study was to highlight the role of the clinical laboratory and the relevance of reporting the case immediately to the unit of hematology for the diagnosis and early administration of treatment in the presence of such an urgent hematologic disease as thrombotic thrombocytopenic purpura (TTP).Case presentationAn elderly patient was referred to the emergency department of our hospital by his general practitioner for speech difficulty, facial asymmetry and weakness in the upper limb. Stroke code was activated. However, laboratory findings (anemia, thrombocytopenia, elevated creatinine, total bilirubin and LDH, negative direct Coombs test) and presence of schistocytes in the peripheral blood smear test were consistent with a completely different diagnosis: TTP thrombotic microangiopathy.ConclusionsThe first diagnostic approach of left hemispheric stroke was not confirmed in the laboratory, with findings of nonautoimmune hemolytic anemia, thrombocytopenia without apparent cause and presence of schistocytes. We should not forget that the clinical manifestations of this condition are widely variable and may include multiorganic dysfunction. Although confirmation of diagnosis is based on ADAMTS-13, its associated high mortalitiy requires immediate treatment on mere suspicion.

scholarly journals The retrospective analysis of the anamnestic, clinical and laboratory data in patients with chronicidiopathic urticaria

2011 ◽  
Vol 8 (4) ◽  
pp. 23-33
Author(s):  
R N Golubchikova ◽  
I V Danilycheva ◽  
O Yu Rebrova ◽  
R N Golubchikova ◽  
I V Danilycheva ◽  
...  
Keyword(s):  
Premenstrual Syndrome ◽  
Clinical Laboratory ◽  
Health Hazard ◽  
Laboratory Data ◽  
Atopic Disease ◽  
Chronic Idiopathic Urticaria ◽  
Laboratory Findings ◽  
Autoimmune Pathology ◽  
Gastrointestinal Problems ◽  
H Pylori

Background. analysis of the anamnestic, clinical laboratory findings in patients with chronic idiopathic urticaria. Methods. The retrospective study of the anamnestic clinical laboratory findings in patients with chronic idiopathic. Results. women are predominant (3,4:1), 72% chronic idiopathic urticaria in the course of less or equal 5 years, 73% of patients suffer from urticaria and angioedema, triggers of urticaria are stress in 62% of patients, food in 27%, medications in 24%, acute respiratory disease in 12%, premenstrual syndrome in 6%. The part of patients with autoimmune thyroiditis is 21%. 46% of patients had signs of autoimmune pathology. 20% have antiparasitic antibodies. 100% of patients have gastrointestinal problems, 67% - chronic tonsillitis, 14% - atopic disease, 9% - parasitosis. in 43% of patients H. pylori infection was found. changed parameters of bacteriological studies of feces were detected in 85% of patients. There were no health hazard conditions.

Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis under Treatment with Tocilizumab

2015 ◽  
Vol 42 (4) ◽  
pp. 712-722 ◽  
Author(s):  
Shumpei Yokota ◽  
Yasuhiko Itoh ◽  
Tomohiro Morio ◽  
Naokata Sumitomo ◽  
Kaori Daimaru ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Macrophage Activation Syndrome ◽  
Macrophage Activation ◽  
Clinical Laboratory ◽  
Laboratory Data ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Clinical Manifestations ◽  
Safety Evaluation ◽  
Laboratory Findings ◽  
Activation Syndrome

Objective.To identify macrophage activation syndrome (MAS) in patients with systemic juvenile idiopathic arthritis (sJIA) undergoing tocilizumab (TCZ) treatment, and to confirm laboratory marker changes and responses to treatment in patients with MAS receiving TCZ.Methods.In Japan, 394 patients with sJIA were registered in an all-patient registry surveillance of TCZ as of January 15, 2012. TCZ (8 mg/kg) was administered every 2 weeks to patients with sJIA. MAS, hemophagocytic lymphohistiocytosis, or Epstein-Barr virus–associated hemophagocytic syndrome (EB-VAHS) was reported in 23 of these patients (25 events). The Safety Evaluation Committee of Tocilizumab for JIA reviewed these cases and clinically evaluated the data and laboratory findings using their own therapeutic experience. Events were categorized into 4 groups: definitive MAS, probable MAS, EB-VAHS, and non-MAS.Results.The committee’s review revealed 3 events of definitive MAS in 3 patients, 12 events of probable MAS in 11 patients, 2 events of EB-VAHS in 2 patients, and 8 events of non-MAS in 8 patients. There were 2 patients who developed 2 events: 2 events in 1 patient were classified into definitive MAS and probable MAS, and 2 events in another patient were classified into probable MAS. In patients with definitive or probable MAS, common clinical manifestations and laboratory findings of MAS were observed. Changes in laboratory data observed in patients with EB-VAHS were similar to those observed in patients with MAS.Conclusion.These results suggest that the clinical/laboratory features in the course of MAS appear to be similar among patients regardless of whether TCZ is administered. Similarities in the pathophysiological background of MAS and EB-VAHS were also suggested.

scholarly journals Clinical and laboratory findings of patients with the possible diagnosis of influenza hospitalized in affiliated hospitals of Babol University of Medical Sciences, 2015-2016

2018 ◽  
Vol 31 (3) ◽  
pp. 113-116 ◽  
Author(s):  
Mostafa Javanian ◽  
Arefeh Babazadeh ◽  
Soheil Ebrahimpour ◽  
Mehran Shokri ◽  
Masomeh Bayani
Keyword(s):  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Medical Sciences ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Epidemiological Characteristics

Abstract The clinical and para clinical manifestations of influenza in various patients have range from an autoimmune disease to a life-threatening respiratory infection. In addition, the severity of the disease is influenced by factors such as demographic factors, underlying diseases, and immune response. Therefore, in this study, we evaluated the clinical, laboratory and epidemiological characteristics of patients with this type of influenza in Babol (north of Iran). This study was conducted as a descriptive cross-sectional study from October 2015 to March 2016. Subsequently, in this study, records of 123 patients with clinical signs of the influenza-like disease who have undergone the clinical sign in hospitals affiliated to Babol University of Medical Sciences were reviewed. Of 123 patients admitted to a possible diagnosis of influenza, 58 patients (47.2%) were PCR positive for H1N1, while seventy nine (64.2%) participants were women and 21 (17.1%) had diabetes or underlying lung disease. Most of the involved age groups were of individuals above the age of 50. These were followed by the 21-35 years-old. Fever (78%), cough (65.9%), shivering (58.5%) and myalgia (56.1%) were the most common clinical symptoms. Increased levels of transaminases (43.1%), leukocytosis (35.8%) and thrombocytopenia (34.2%) were as well reported in patients as the most frequently reported para clinical findings. In the present study, the most usual clinical symptoms were fever, cough, chill, and myalgia, while gastrointestinal symptoms were also noticeably observed in patients. In an experimental study, a significant number of patients showed leukocytosis and thrombocytopenia and increased transaminases.

scholarly journals Evaluation of Subacute Thyroiditis: Frequency, Clinical Manifestation and Laboratory Findings

2021 ◽  
Author(s):  
Marziyeh Bagheri ◽  
farhad Abbasi ◽  
Kamran Mirzaei ◽  
Manizhe mohamadi ◽  
mohammadreza kalantarhormozi
Keyword(s):  
Sore Throat ◽  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Subacute Thyroiditis ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Inappropriate Treatment ◽  
One Year

Abstract Introduction: Subacute thyroiditis (SAT) is a type of viral thyroiditis, which is often a self-limiting illness, but it causes diagnostic mistakes due to a number of clinical symptoms and leads to inappropriate treatment. In this study, clinical, laboratory and demographic findings of patients have been investigatedMethods: This descriptive cross-sectional study was performed on 40 patients (27 female-13 male) with subacute thyroiditis during one year. Data included age, sex, clinical symptoms (fever, sore throat, otalgia, fatigue, sweating ...) and laboratory findings. (ESR, CRP, TSH, T4 and WBC). Their files were extracted and analyzed with SPSS.Results: In this study, 67% of the patients were women with the mean age of 38.48 ± 8.7. Female to male ratio was 2.7 to 1. The most common clinical symptoms were fever (57.5%) and sore throat (55%). Laboratory findings: ESR, TSH,T4 and WBC with average of 67.32, 0.283, 15.368 and 12.456, respectively. CRP positive in 80% of patients who underwent this test. 80 percent of the patients responded to the treatment. The recurrence rate was estimated 42% and 11% for those who received NSAIDs and Prednisolone, respectivelyConclusion: In this study, SAT was most prevalent in women in their fourth decade of life. Clinical symptoms were consistent with most studies in terms of prevalence and incidence. There was no significant association between the age and sex of the patients and their clinical manifestations and laboratory results from laboratory considerations, low concentrations of TSH, high levels of ESR and positive CRP were found to be helpful in diagnosis. Prednisolone proved to be more effective in treating SAT.

scholarly journals Ophthalmic involvement disparities in clinical characteristics of IgG4-related disease: a retrospective study of 573 patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Linyang Gan ◽  
Xuan Luo ◽  
Yunyun Fei ◽  
Linyi Peng ◽  
Jiaxin Zhou ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Chinese Patients ◽  
Obliterative Phlebitis ◽  
Laboratory Findings ◽  
Male Predominance ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Serum Igg4

Abstract Purpose To investigate the clinical manifestations of orbital involvement in a large cohort of Chinese patients with IgG4-related disease (IgG4-RD). Methods A total of 573 patients with IgG4-related disease were included. We described and compared the demographic, clinical, laboratory and histopathologic findings from 314 patients with IgG4-related ophthalmic disease (IgG4-ROD) and 259 with extra-ophthalmic IgG4-RD. Results Male predominance was found significant in extra-ophthalmic IgG4-RD only. Patients with IgG4-ROD showed younger age at diagnosis and longer duration from onset till diagnosis. In patients with extra-ophthalmic IgG4-RD, the most commonly involved extra-ophthalmic organ was pancreas; while in IgG4-ROD patients, salivary gland was most frequently affected. Multivariate analysis exhibited IgG4-ROD was associated with allergy history, higher serum IgG4/IgG ratio, multiple organs involvement and sialoadenitis. Orbital images were reviewed in 173 (55.1%) IgG4-ROD patients. Fifty-one (29.5%) patients had multiple lesions. Lacrimal gland involvement was detected in 151 (87.3%) patients, followed by extraocular muscles (40, 23.1%), other orbital soft tissue (40, 23.1%) and trigeminal nerve (8, 4.6%). Biopsy was performed from various organs in 390 cases. A dense lymphoplasmacytic infiltration and fibrosis were the main feature in orbital specimens. Storiform fibrosis and obliterative phlebitis were absent in lacrimal gland. Conclusions Lacrimal gland involvement was the most common orbital manifestation of IgG4-ROD. Patients with IgG4-ROD showed different characteristic in demographic, clinical, laboratory findings compared to patients with extra-ophthalmic IgG4-RD. These features might indicate potential differences in the pathogenesis of these two subgroups of IgG4-RD.

THE CLINICAL, LABORATORY MANIFESTATIONS AND HISTOPATHOLOGY IN NEPHROTIC PATIENTS WITH LUPUS NEPHRITIS

2018 ◽  
pp. 52-58
Author(s):  
Le Thuan Nguyen ◽  
Bui Bao Hoang
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Clinical Laboratory ◽  
Activity Index ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Organ Systems ◽  
Tubulointerstitial Lesions

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ systems. The kidney appears to be the most commonly affected organ, especially nephrotic is a serious kidney injury. The clinical, laboratory manifestations and histopathology are very useful for diagnosis, provide the means of predicting prognosis and guiding therapy in nephrotic patients with lupus nephritis. Methods: Descriptive cross-sectional study of nephrotic patients with lupus treated in the Department of Nephrology Trung Vuong Hospital and Cho Ray Hospital between May/2014 and May/2017. Renal histopathological lesions were classified according to International Society of Nephrology/Renal Pathology Society - ISN/RPS ’s 2003. The clinical, laboratory manifestations and histopathological features were described. Results: Of 32 LN with nephritic range proteinuria cases studied, 93.7% were women. The 3 most common clinical manifestations were edema (93.8%), hypertension (96.8%) and pallor (68.9%), musculoskeletal manifestions (46.9%), malar rash (40.6%). There was significant rise in laboratory and immunological manifestions with hematuria (78.1%), Hb < 12g/dL (93.5%), increased Cholesterol (100%), and Triglycerid (87.5%), Creatinine > 1.4 mg/dL (87.5%), increased BUN 71.9%, ANA (+) 93.8%, Anti Ds DNA(+) 96.9%, low C3: 96.9%, low C4: 84.4%. The most various and severe features were noted in class IV with active tubulointerstitial lesions and high activity index. Conclusion: Lupus nephritis with nephrotic range proteinuria has the more severity of histopathological feature and the more severity of the more systemic organ involvements and laboratory disorders were noted. Key words: Systemic lupus, erythematosus (SLE) lupus nepphritis, clinical

Sign in / Sign up

Export Citation Format

Share Document