The expression of vascular endothelial growth factor in synovial tissues in patients with internal derangement of the temporomandibular joint

2002 ◽  
Vol 93 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Jun Sato ◽  
Natsuki Segami ◽  
Toshikazu Suzuki ◽  
Keiseki Kaneyama ◽  
Yoshino Yoshitake ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Temporomandibular Joint ◽  
Internal Derangement ◽  
Vascular Endothelial ◽  
Synovial Tissues ◽  
Endothelial Growth Factor

Correlations of the Expression of Fibroblast Growth Factor-2, Vascular Endothelial Growth Factor, and their Receptors with Angiogenesis in Synovial Tissues from Patients with Internal Derangement of the Temporomandibular Joint

2003 ◽  
Vol 82 (4) ◽  
pp. 272-277 ◽  
Author(s):  
J. Sato ◽  
N. Segami ◽  
Y. Yoshitake ◽  
K. Nishikawa
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Microvessel Density ◽  
Internal Derangement ◽  
Fibroblast Growth Factor 2 ◽  
Vascular Endothelial ◽  
Fibroblast Growth ◽  
Synovial Tissues ◽  
Endothelial Growth Factor

Synovitis in internal derangement of the temporomandibular joint (TMJ) is accompanied by the growth of new blood vessels. Fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) are well-characterized angiogenic factors. The objective of this study was to elucidate the correlation between the expression of FGF-2, VEGF, and their receptors—FGF receptor-1 (FGFR-1) and VEGF receptor-1 (Flt-1)—with microvessel density in synovial tissues of the TMJ. Using an immunohistochemical technique, we examined 47 joints (45 patients) with internal derangement. Individual microvessel density was evaluated by means of the CD34 antibody, a specific endothelial marker. The correlation between the percentage of immuno-positive cells and microvessel density was evaluated. In multiple logistic regression analysis, the correlation between the percentage of Flt-1-positive cells and microvessel density was significant [p = 0.005, odds ratio = 1.071, 95% confidence interval = 1.021-1.124]. These results suggest that the expression of the VEGF/Flt-1 system is involved in angiogenesis in inflamed synovial tissue in the TMJ.

scholarly journals Effects of Vascular Endothelial Growth Factor (VEGF) on the Progression of Osteoarthritis in the Mouse Temporomandibular Joint

2021 ◽  
Vol 30 (2) ◽  
pp. 137-144
Author(s):  
Arihiro Nakamura ◽  
Nobumi Ogi ◽  
Yoshihiko Sugita ◽  
Hatsuhiko Maeda ◽  
Toru Nagao ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Temporomandibular Joint ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Expression of vascular endothelial growth factor in human dysfunctional temporomandibular joint discs

2003 ◽  
Vol 48 (3) ◽  
pp. 185-192 ◽  
Author(s):  
R Leonardi ◽  
L Lo Muzio ◽  
G Bernasconi ◽  
C Caltabiano ◽  
C Piacentini ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Temporomandibular Joint ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Joint Discs
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