Recent Advances in Steroid Synthesis: A Tribute to Sir Derek Barton

The synthesis of steroids and gaining an ultimate understanding of their reactivity was one of Sir Derek Barton’s most notable research areas. This highlight will focus on the construction of the steroid ring system from 2016 to 2018, and will include pathways that eventually led to natural product synthesis. For example, efficient syntheses of ent-pregnanolone sulfate and oestradiol methyl ether will be explained along with the total synthesis of cannogenol-3-O-α-l-rhamnoside.

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Recent advances in the total synthesis of cyclobutane-containing natural products

Organic Chemistry Frontiers ◽

10.1039/c9qo01178a ◽

2020 ◽

Vol 7 (1) ◽

pp. 136-154 ◽

Cited By ~ 15

Author(s):

Jinshan Li ◽

Kai Gao ◽

Ming Bian ◽

Hanfeng Ding

Keyword(s):

Natural Products ◽

Total Synthesis ◽

Natural Product ◽

Natural Product Synthesis ◽

Recent Advances ◽

Recent Developments

Recent developments of strategies on the construction of cyclobutanes and their application in complex natural product synthesis are discussed.

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Recent Advances on the Application of Electrocyclic Reactions in Complex Natural Product Synthesis

Synthesis ◽

10.1055/s-0036-1590870 ◽

2017 ◽

Vol 28 (19) ◽

pp. 4383-4413 ◽

Cited By ~ 21

Author(s):

Ming Bian ◽

Hanfeng Ding ◽

Lekai Li

Keyword(s):

Natural Products ◽

Total Synthesis ◽

Natural Product ◽

Natural Product Synthesis ◽

Electrocyclic Reactions ◽

Recent Advances ◽

Electrocyclic Reaction

The electrocyclic reaction is one of the most powerful tools for the construction of complex polycyclic scaffolds in a highly stereocontrolled fashion. In this review, recent advances in its application in the total synthesis of representative natural products are discussed, with the aim of providing a complement to existing reviews.1 Introduction2 4π Electrocyclization2.1 Neutral 4π Electrocyclization2.2 Cationic 4π Electrocyclization3 6π Electrocyclization3.1 All-Carbon 6π Electrocyclization3.2 Oxa-6π Electrocyclization3.3 Aza-6π Electrocyclization3.4 Retro-6π Electrocyclization4 8π Electrocyclization5 Conclusion and Outlook

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Editorial [Hot topic: Recent Advances in Cycloaddition Reactions in Natural Product Synthesis (Guest Editor: Jetze J. Tepe)]

Current Organic Synthesis ◽

10.2174/157017910791414481 ◽

2010 ◽

Vol 7 (4) ◽

pp. 311-311

Author(s):

Jetze J. Tepe

Keyword(s):

Natural Product ◽

Guest Editor ◽

Natural Product Synthesis ◽

Cycloaddition Reactions ◽

Recent Advances

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Natural product synthesis via allylsilanes. 1. Synthesis and reactions of (1E,3E)-4-acetoxy-1-(trimethylsilyl)-1,3-butadiene and its use in the total synthesis of (.+-.)-shikimic acid

Journal of the American Chemical Society ◽

10.1021/ja00372a034 ◽

1982 ◽

Vol 104 (8) ◽

pp. 2308-2310 ◽

Cited By ~ 53

Author(s):

Masato Koreeda ◽

Marco A. Ciufolini

Keyword(s):

Total Synthesis ◽

Natural Product ◽

Shikimic Acid ◽

Natural Product Synthesis

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Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products

Organic & Biomolecular Chemistry ◽

10.1039/c9ob01212e ◽

2019 ◽

Vol 17 (31) ◽

pp. 7270-7292 ◽

Cited By ~ 7

Author(s):

Sagar S. Thorat ◽

Ravindar Kontham

Keyword(s):

Natural Products ◽

Total Synthesis ◽

Natural Product ◽

Medicinal Chemistry ◽

Natural Product Chemistry ◽

Structural Motifs ◽

Recent Advances ◽

Synthetic Molecules ◽

Product Chemistry

Oxaspirolactones are ubiquitous structural motifs found in natural products and synthetic molecules with a diverse biochemical and physicochemical profile, and represent a valuable target in natural product chemistry and medicinal chemistry.

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