Limitations of the Phenolphthalein Competition Method for Estimating Cyclodextrin Binding Constants
Keyword(s):
The phenolphthalein competitive spectrophotometric technique was used to obtain binding constants for cyclodextrin complexes for a variety of both inclusates and cyclodextrins . The former included alkane-1-sulfonates (C5-C12), alkyl sulfates (C6, C8, C12) and several heterocyclic ligands, and the latter included β-cyclodextrin, dimethyl-β-cyclodextrin and γ- cyclodextrin . The technique was not successful for either α- cyclodextrin or trimethyl -β- cyclodextrin inclusion complexes, or with many primary amines and quaternary ammonium cationic surfactants. However, for many colourless inclusates this method is a simple, convenient, reliable route to cyclodextrin binding constants.
2020 ◽
Vol 1623
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pp. 461209
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2019 ◽
Vol 93
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pp. 2735-2743
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1982 ◽
Vol 55
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pp. 1246-1249
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2017 ◽
Vol 39
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pp. 556-563
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2012 ◽
Vol 4
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pp. 4665-4671
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