scholarly journals Asymmetric Catalysis Special Feature Part I: Catalytic asymmetric synthesis of all-carbon quaternary stereocenters

2004 ◽  
Vol 101 (15) ◽  
pp. 5363-5367 ◽  
Author(s):  
C. J. Douglas ◽  
L. E. Overman
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Catalysis ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric ◽  
Quaternary Stereocenters

Catalytic asymmetric synthesis of pyrrolidine derivatives bearing heteroatom-substituted quaternary stereocenters

2018 ◽  
Vol 5 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Zhi-Peng Wang ◽  
Qi Wu ◽  
Jia Jiang ◽  
Zi-Rui Li ◽  
Xiao-Jiao Peng ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric ◽  
Quaternary Stereocenters

An enantioselective [3 + 2] cycloaddition of heteroatom-substituted alkenes with α-substituted isocyanoacetates has been developed. Excellent reactivity and enantioselectivity were obtained.

Enantioselective synthesis of spiroacetals: the conquest of a long-sought goal in asymmetric catalysis

2014 ◽  
Vol 12 (29) ◽  
pp. 5324-5330 ◽  
Author(s):  
Lara Cala ◽  
Francisco J. Fañanás ◽  
Félix Rodríguez
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Catalysis ◽  
Enantioselective Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric

This perspective article summarizes the few and recently reported methods on catalytic asymmetric synthesis of spiroacetal derivatives from achiral substrates.

scholarly journals Enantioselective synthesis of tertiary boronic esters through catalytic asymmetric reversed hydroboration

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Tao-Tao Gao ◽  
Hou-Xiang Lu ◽  
Peng-Chao Gao ◽  
Bi-Jie Li
Keyword(s):  
Asymmetric Synthesis ◽  
Amide Group ◽  
Enantioselective Synthesis ◽  
Biologically Active ◽  
Catalytic Asymmetric Synthesis ◽  
Boronic Esters ◽  
Synthetic Intermediates ◽  
Michael Acceptors ◽  
Catalytic Asymmetric ◽  
Quaternary Stereocenters

AbstractChiral tertiary boronic esters are important precursors to bioactive compounds and versatile synthetic intermediates to molecules containing quaternary stereocenters. The development of conjugate boryl addition to α,β-unsaturated amide has been hampered by the intrinsic low electrophilicity of the amide group. Here we show the catalytic asymmetric synthesis of enantioenriched tertiary boronic esters through hydroboration of β,β-disubstituted α,β-unsaturated amides. The Rh-catalyzed hydroboration occurs with previously unattainable selectivity to provide tertiary boronic esters in high enantioselectivity. This strategy opens a door for the hydroboration of inert Michael acceptors with high stereocontrol and may provide future applications in the synthesis of biologically active molecules.

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