scholarly journals Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately

2008 ◽  
Vol 105 (49) ◽  
pp. 19520-19525 ◽  
Author(s):  
X.-b. Wang ◽  
O. Bozdagi ◽  
J. S. Nikitczuk ◽  
Z. W. Zhai ◽  
Q. Zhou ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dendritic Spine ◽  
Long Term Potentiation ◽  
Matrix Metalloproteinase 9 ◽  
Term Potentiation ◽  
Metalloproteinase 9 ◽  
Extracellular Proteolysis

Insights into associative long-term potentiation from computational models of NMDA receptor-mediated calcium influx and intracellular calcium concentration changes

1990 ◽  
Vol 63 (5) ◽  
pp. 1148-1168 ◽  
Author(s):  
W. R. Holmes ◽  
W. B. Levy
Keyword(s):  
Experimental Data ◽  
Nmda Receptor ◽  
Nmda Receptors ◽  
Dendritic Spine ◽  
Long Term Potentiation ◽  
Input Frequency ◽  
Spine Head ◽  
Term Potentiation ◽  
Concentration Changes

1. Because induction of associative long-term potentiation (LTP) in the dentate gyrus is thought to depend on Ca2+ influx through channels controlled by N-methyl-D-aspartate (NMDA) receptors, quantitative modeling was performed of synaptically mediated Ca2+ influx as a function of synaptic coactivation. The goal was to determine whether Ca2+ influx through NMDA-receptor channels was, by itself, sufficient to explain associative LTP, including control experiments and the temporal requirements of LTP. 2. Ca2+ influx through NMDA-receptor channels was modeled at a synapse on a dendritic spine of a reconstructed hippocampal dentate granule cell when 1-115 synapses on spines at different dendritic locations were activated eight times at frequencies of 10-800 Hz. The resulting change in [Ca2+] in the spine head was estimated from the Ca2+ influx with the use of a model of a dendritic spine that included Ca2+ buffers, pumps, and diffusion. 3. To use a compelling model of synaptic activation, we developed quantitative descriptions of the NMDA and non-NMDA receptor-mediated conductances consistent with available experimental data. The experimental data reported for NMDA and non-NMDA receptor-channel properties and data from other non-LTP experiments that separated the NMDA and non-NMDA receptor-mediated components of synaptic events proved to be limiting for particular synaptic variables. Relative to the non-NMDA glutamate-type receptors, 1) the unbinding of transmitter from NMDA receptors had to be slow, 2) the transition from the bound NMDA receptor-transmitter complex to the open channel state had to be even slower, and 3) the average number of NMDA-receptor channels at a single activated synapse on a single spine head that were open and conducting at a given moment in time had to be very small (usually less than 1). 4. With the use of these quantitative synaptic conductance descriptions. Ca2+ influx through NMDA-receptor channels at a synapse was computed for a variety of conditions. For a constant number of pulses, Ca2+ influx was calculated as a function of input frequency and the number of coactivated synapses. When few synapses were coactivated, Ca2+ influx was small, even for high-frequency activation. However, with larger numbers of coactivated synapses, there was a steep increase in Ca2+ influx with increasing input frequency because of the voltage-dependent nature of the NMDA receptor-mediated conductance. Nevertheless, total Ca2+ influx was never increased more than fourfold by increasing input frequency or the number of coactivated synapses.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals Matrix metalloproteinase-dependent shedding of intercellular adhesion molecule-5 occurs with long-term potentiation

Neuroscience ◽  
2010 ◽  
Vol 166 (2) ◽  
pp. 508-521 ◽  
Author(s):  
K. Conant ◽  
Y. Wang ◽  
A. Szklarczyk ◽  
A. Dudak ◽  
M.P. Mattson ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Adhesion Molecule ◽  
Long Term Potentiation ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Term Potentiation

scholarly journals Bistable MAP kinase activity: a plausible mechanism contributing to maintenance of late long-term potentiation

2008 ◽  
Vol 294 (2) ◽  
pp. C503-C515 ◽  
Author(s):  
Paul Smolen ◽  
Douglas A. Baxter ◽  
John H. Byrne
Keyword(s):  
Map Kinase ◽  
Dendritic Spine ◽  
Mapk Pathway ◽  
Long Term Potentiation ◽  
Long Term Memory ◽  
Stable States ◽  
Mapk Activity ◽  
Stochastic Fluctuations ◽  
Term Potentiation

Bistability of MAP kinase (MAPK) activity has been suggested to contribute to several cellular processes, including differentiation and long-term synaptic potentiation. A recent model (Markevich NI, Hoek JB, Kholodenko BN. J Cell Biol 164: 353–359, 2004) predicts bistability due to interactions of the kinases and phosphatases in the MAPK pathway, without feedback from MAPK to earlier reactions. Using this model and enzyme concentrations appropriate for neurons, we simulated bistable MAPK activity, but bistability was present only within a relatively narrow range of activity of Raf, the first pathway kinase. Stochastic fluctuations in molecule numbers eliminated bistability for small molecule numbers, such as are expected in the volume of a dendritic spine. However, positive-feedback loops have been posited from MAPK up to Raf activation. One proposed loop in which MAPK directly activates Raf was incorporated into the model. We found that such feedback greatly enhanced the robustness of both stable states of MAPK activity to stochastic fluctuations and to parameter variations. Bistability was robust for molecule numbers plausible for a dendritic spine volume. The upper state of MAPK activity was resistant to inhibition of MEK activation for >1 h, which suggests that inhibitor experiments have not sufficed to rule out a role for persistent MAPK activity in the maintenance of long-term potentiation (LTP). These simulations suggest that persistent MAPK activity and consequent upregulation of translation may contribute to LTP maintenance and to long-term memory. Experiments using a fluorescent MAPK substrate may further test this hypothesis.

scholarly journals Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid β-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss

2016 ◽  
Vol 89 (5) ◽  
pp. 552-559 ◽  
Author(s):  
Ronald K. Freund ◽  
Emily S. Gibson ◽  
Huntington Potter ◽  
Mark L. Dell’Acqua
Keyword(s):  
Dendritic Spine ◽  
Amyloid Β ◽  
Motor Protein ◽  
Long Term Potentiation ◽  
Term Potentiation

scholarly journals miR-132 Regulates Dendritic Spine Structure by Direct Targeting of Matrix Metalloproteinase 9 mRNA

2015 ◽  
Vol 53 (7) ◽  
pp. 4701-4712 ◽  
Author(s):  
Magdalena Jasińska ◽  
Jacek Miłek ◽  
Iwona A. Cymerman ◽  
Szymon Łęski ◽  
Leszek Kaczmarek ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dendritic Spine ◽  
Matrix Metalloproteinase 9 ◽  
Direct Targeting ◽  
Spine Structure ◽  
Metalloproteinase 9

scholarly journals Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

Neuron ◽  
2014 ◽  
Vol 82 (2) ◽  
pp. 444-459 ◽  
Author(s):  
Miquel Bosch ◽  
Jorge Castro ◽  
Takeo Saneyoshi ◽  
Hitomi Matsuno ◽  
Mriganka Sur ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Long Term Potentiation ◽  
Term Potentiation
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