scholarly journals miR-17 92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease

2013 ◽  
Vol 110 (26) ◽  
pp. 10765-10770 ◽  
Author(s):  
V. Patel ◽  
D. Williams ◽  
S. Hajarnis ◽  
R. Hunter ◽  
M. Pontoglio ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Mirna Cluster ◽  
Polycystic Kidney ◽  
Kidney Cyst ◽  
Cyst Growth

Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease

NEJM Evidence ◽  
2021 ◽  
Author(s):  
Gopala K. Rangan ◽  
Annette T.Y. Wong ◽  
Alexandra Munt ◽  
Jennifer Q.J. Zhang ◽  
Sayanthooran Saravanabavan ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Arginine Vasopressin ◽  
Autosomal Dominant ◽  
Urine Osmolality ◽  
Polycystic Kidney ◽  
Vasopressin Release ◽  
Kidney Cyst ◽  
Autosomal Dominant Polycystic Kidney ◽  
Cyst Growth

In patients with autosomal dominant polycystic kidney disease (ADPKD), drinking more water could potentially reduce urine osmolality and suppress arginine vasopressin release and decrease the rate of kidney cyst growth and its associated organ dysfunction. In a 3-year trial, adults with ADPKD randomized to drink more water so as to lower urine osmolality did not have slower kidney growth than did a group who drank water as they wished.

scholarly journals Effect of Early and Delayed Commencement of Paricalcitol in Combination with Enalapril on the Progression of Experimental Polycystic Kidney Disease

2021 ◽  
Vol 8 (11) ◽  
pp. 144
Author(s):  
Priyanka S. Sagar ◽  
Sayanthooran Saravanabavan ◽  
Alexandra Munt ◽  
Annette T. Y. Wong ◽  
Gopala K. Rangan
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Enzyme Inhibitor ◽  
Weight Ratio ◽  
Cellular Growth ◽  
Polycystic Kidney ◽  
Kidney Cyst ◽  
Established Disease ◽  
Cyst Growth

Vitamin D secosteroids are intranuclear regulators of cellular growth and suppress the renin-angiotensin system. The aim of this study was to test the hypothesis that the vitamin D receptor agonist, paricalcitol (PC), either alone or with enalapril (E) (an angiotensin-converting enzyme inhibitor), reduces the progression of polycystic kidney disease. Preventative treatment of Lewis polycystic kidney (LPK) and Lewis control rats with PC (0.2 μg/kg i.p. 5 days/week) or vehicle from postnatal weeks 3 to 10 did not alter kidney enlargement. To evaluate the efficacy in established disease, LPK rats received either PC (0.8 μg/kg i.p; 3 days/week), vehicle, E (50 mg/L in water) or the combination of PC + E from weeks 10 to 20. In established disease, PC also did not alter the progression of kidney enlargement, kidney cyst growth or decline in renal function in LPK rats. Moreover, the higher dose of PC was associated with increased serum calcium and weight loss. However, in established disease, the combination of PC + E reduced systolic blood pressure and heart-body weight ratio compared to vehicle and E alone (p < 0.05). In conclusion, the combination of PC + E attenuated cardiovascular disease but caused hypercalcaemia and did not alter kidney cyst growth in LPK rats.

scholarly journals Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease

EBioMedicine ◽  
2019 ◽  
Vol 47 ◽  
pp. 436-445 ◽  
Author(s):  
Wouter N. Leonhard ◽  
Xuewen Song ◽  
Anish A. Kanhai ◽  
Ioan-Andrei Iliuta ◽  
Andrea Bozovic ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Mouse Model ◽  
Polycystic Kidney Disease ◽  
Adult Onset ◽  
Polycystic Kidney ◽  
Kidney Cyst ◽  
Cyst Growth

scholarly journals Salsalate, But Not Metformin or Canagliflozin, Slows Kidney Cyst Growth in an Adult-Onset Mouse Model of Polycystic Kidney Disease

2019 ◽  
Author(s):  
Wouter N. Leonhard ◽  
Xuewen Song ◽  
Anish A. Kanhai ◽  
Ioan-Andrei Iliuta ◽  
Andrea Bozovic ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Mouse Model ◽  
Polycystic Kidney Disease ◽  
Adult Onset ◽  
Polycystic Kidney ◽  
Kidney Cyst ◽  
Cyst Growth

scholarly journals Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Hao Ding ◽  
Linda Xiaoyan Li ◽  
Peter C. Harris ◽  
Junwei Yang ◽  
Xiaogang Li
Keyword(s):  
Kidney Disease ◽  
Epithelial Cells ◽  
Polycystic Kidney Disease ◽  
Extracellular Vesicles ◽  
Autosomal Dominant ◽  
Therapeutic Potential ◽  
Polycystic Kidney ◽  
Renal Epithelial Cells ◽  
Autosomal Dominant Polycystic Kidney ◽  
Cyst Growth

AbstractAutosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal allele. However, if and how null ADPKD gene renal epithelial cells affect the biology and function of neighboring cells, including heterozygous renal epithelial cells, fibroblasts and macrophages during cyst initiation and expansion remains unknown. Here we address this question with a “cystic extracellular vesicles/exosomes theory”. We show that cystic cell derived extracellular vesicles and urinary exosomes derived from ADPKD patients promote cyst growth in Pkd1 mutant kidneys and in 3D cultures. This is achieved by: 1) downregulation of Pkd1 gene expression and upregulation of specific miRNAs, resulting in the activation of PKD associated signaling pathways in recipient renal epithelial cells and tissues; 2) the activation of fibroblasts; and 3) the induction of cytokine expression and the recruitment of macrophages to increase renal inflammation in cystic kidneys. Inhibition of exosome biogenesis/release with GW4869 significantly delays cyst growth in aggressive and milder ADPKD mouse models, suggesting that targeting exosome secretion has therapeutic potential for ADPKD.

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