scholarly journals Evidence for close side-chain packing in an early protein folding intermediate previously assumed to be a molten globule

2014 ◽  
Vol 111 (41) ◽  
pp. 14746-14751 ◽  
Author(s):  
L. E. Rosen ◽  
K. B. Connell ◽  
S. Marqusee
Keyword(s):  
Protein Folding ◽  
Molten Globule ◽  
Side Chain ◽  
Folding Intermediate ◽  
Chain Packing ◽  
Early Protein ◽  
Side Chain Packing

Does the molten globule have a native-like tertiary fold?

1995 ◽  
Vol 348 (1323) ◽  
pp. 43-47 ◽  
Keyword(s):  
Protein Folding ◽  
Molten Globule ◽  
Side Chain ◽  
Structural Rearrangements ◽  
Chain Packing ◽  
Folding Intermediates ◽  
Final Structure ◽  
Helical Domain ◽  
Side Chain Packing

One of the mysteries in protein folding is how folding intermediates direct a protein to its unique final structure. To address this question, we have studied the molten globule formed by the α-helical domain of α-lactalbumin (α-LA) and demonstrated that it has a native-like tertiary fold, even in the absence of rigid, extensive side chain packing. These studies suggest that the role of molten globule intermediates in protein folding is to maintain an approximate native backbone topology while still allowing minor structural rearrangements to occur.

scholarly journals Effects of side-chain packing on the formation of secondary structures in protein folding

2010 ◽  
Vol 132 (6) ◽  
pp. 065105 ◽  
Author(s):  
Satoshi Yasuda ◽  
Takashi Yoshidome ◽  
Hiraku Oshima ◽  
Ryota Kodama ◽  
Yuichi Harano ◽  
...  
Keyword(s):  
Protein Folding ◽  
Secondary Structures ◽  
Side Chain ◽  
Chain Packing ◽  
Side Chain Packing

Side Chain Packing of the N- and C-Terminal Helices Plays a Critical Role in the Kinetics of CytochromecFolding†

Biochemistry ◽  
1996 ◽  
Vol 35 (17) ◽  
pp. 5538-5549 ◽  
Author(s):  
Wilfredo Colón ◽  
Gülnur A. Elöve ◽  
L. Paul Wakem ◽  
Fred Sherman ◽  
Heinrich Roder
Keyword(s):  
Critical Role ◽  
Side Chain ◽  
Chain Packing ◽  
Kinetics Of ◽  
Side Chain Packing
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