scholarly journals Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain

2020 ◽  
Vol 117 (18) ◽  
pp. 10015-10023 ◽  
Author(s):  
Meena M. Makary ◽  
Pablo Polosecki ◽  
Guillermo A. Cecchi ◽  
Ivan E. DeAraujo ◽  
Daniel S. Barron ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Nucleus Accumbens ◽  
Chronic Low Back Pain ◽  
Chronic Back Pain ◽  
Chronic Phase ◽  
Anterior Cingulate ◽  
Low Back ◽  
Pain Patients

Chronic pain is a highly prevalent disease with poorly understood pathophysiology. In particular, the brain mechanisms mediating the transition from acute to chronic pain remain largely unknown. Here, we identify a subcortical signature of back pain. Specifically, subacute back pain patients who are at risk for developing chronic pain exhibit a smaller nucleus accumbens volume, which persists in the chronic phase, compared to healthy controls. The smaller accumbens volume was also observed in a separate cohort of chronic low-back pain patients and was associated with dynamic changes in functional connectivity. At baseline, subacute back pain patients showed altered local nucleus accumbens connectivity between putative shell and core, irrespective of the risk of transition to chronic pain. At follow-up, connectivity changes were observed between nucleus accumbens and rostral anterior cingulate cortex in the patients with persistent pain. Analysis of the power spectral density of nucleus accumbens resting-state activity in the subacute and chronic back pain patients revealed loss of power in the slow-5 frequency band (0.01 to 0.027 Hz) which developed only in the chronic phase of pain. This loss of power was reproducible across two cohorts of chronic low-back pain patients obtained from different sites and accurately classified chronic low-back pain patients in two additional independent datasets. Our results provide evidence that lower nucleus accumbens volume confers risk for developing chronic pain and altered nucleus accumbens activity is a signature of the state of chronic pain.

Chronic pain and depression. III. Family history study of depression and alcoholism in chronic low back pain patients

Pain ◽  
1986 ◽  
Vol 24 (2) ◽  
pp. 185-190 ◽  
Author(s):  
Randal D. France ◽  
Ranga K. Rama Krishnan ◽  
Mary Trainor
Keyword(s):  
Chronic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Family History ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Pain Patients

Chronic pain and depression. II. Symptoms of anxiety in chronic low back pain patients and their relationship to subtypes of depression

Pain ◽  
1985 ◽  
Vol 22 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Ranga Rama K. Krishnan ◽  
Randal D. France ◽  
Susan Pelton ◽  
Una D. McCann ◽  
Jonathan Davidson ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Pain Patients

Chronic pain and depression. I. Classification of depression in chronic low back pain patients

Pain ◽  
1985 ◽  
Vol 22 (3) ◽  
pp. 279-287 ◽  
Author(s):  
Ranga Rama K. Krishnan ◽  
Randal D. France ◽  
Susan Pelton ◽  
Una D. McCann ◽  
Jonathan Davidson ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Pain Patients

Brain Metabolite Changes in the Anterior Cingulate Cortex of Chronic Low Back Pain Patients and Correlations Between Metabolites and Psychological State

2018 ◽  
Vol 34 (7) ◽  
pp. 657-663 ◽  
Author(s):  
Takuya Kameda ◽  
Sei Fukui ◽  
Ryoji Tominaga ◽  
Miho Sekiguchi ◽  
Narihito Iwashita ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Anterior Cingulate Cortex ◽  
Chronic Low Back Pain ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Psychological State ◽  
Low Back ◽  
Brain Metabolite ◽  
Pain Patients

Exposure to Odors Increases Pain Threshold in Chronic Low Back Pain Patients

Pain Medicine ◽  
2020 ◽  
Vol 21 (10) ◽  
pp. 2546-2551
Author(s):  
Gudrun Gossrau ◽  
Daniel Baum ◽  
Thea Koch ◽  
Rainer Sabatowski ◽  
Thomas Hummel ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Chronic Back Pain ◽  
Olfactory Function ◽  
Low Back ◽  
Pain Thresholds ◽  
Test Kit ◽  
Pain Patients ◽  
Olfactory Training

Abstract Objectives Structured exposure to odors is an acknowledged therapy in patients with smell loss but has also been shown to be effective in depression. The latter might rely on connections between olfactory and emotional structures, suggesting possible effects of a similar approach in pain patients. Based on neuroanatomy, there are several interfaces between the “pain matrix” and olfactory system, such as the limbic system, hypothalamus, and mediodorsal thalamus. We aimed to investigate whether structured exposure to odors may impact perceived pain in patients with chronic low back pain. Design Randomized controlled parallel-group design. Subjects were tested on two occasions, at baseline and after four weeks. Setting Ambulatory. Subjects Forty-two patients with chronic low back pain Methods For all patients, olfactory function (using the “Sniffin’Sticks” test kit), detection, and pain thresholds for cutaneous electrical stimuli (applied to the forearm) were tested at baseline and after four weeks. Twenty-eight patients exposed themselves to four odors (rose, vanilla, chocolate, peach) every two hours over a period of four weeks (training group). Control patients (N = 14) underwent no such “olfactory training” (nontraining group). Results Pain thresholds were significantly increased in patients who performed olfactory training compared with patients who did not train with odors. Detection thresholds and olfactory function remained unchanged. Conclusions The present results indicate that regular exposure to odors increases pain thresholds in patients with chronic back pain and could be useful for general pain control in these patients. Furthermore, olfactory training in chronic pain patients might help to reduce chronification of pain by desensitization.

scholarly journals Brain-Derived Neurotrophic Factor and Immune Cells in Osteoarthritis, Chronic Low Back Pain, and Chronic Widespread Pain Patients: Association with Anxiety and Depression

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 327
Author(s):  
Dominique Josephine Dimmek ◽  
Christoph Korallus ◽  
Sabine Buyny ◽  
Gutenbrunner Christoph ◽  
Ralf Lichtinghagen ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Immune Cells ◽  
Chronic Widespread Pain ◽  
Anxiety And Depression ◽  
Low Back ◽  
Widespread Pain ◽  
Chronic Pain Patients ◽  
Pain Patients

Background and Objectives: Musculoskeletal dysfunction can induce several types of chronic pain syndromes. It is of particular interest to elucidate the pathomechanism of different forms of chronic pain. It is possible that patients who have developed chronic widespread pain (CWP) may endure different pathomechanisms as compared to those who suffer from local pain (osteoarthritis, OA) and regional pain (chronic low back pain, cLBP), especially with regard to pain regulation and its related biomediators. The aim of this study was to determine the differences in pathomechanisms among these patients by measuring pain-related biomediators, particularly brain-derived neurotrophic factor (BDNF). Additionally, subpopulations of immune cells were determined in parallel. Materials and Methods: Patients and healthy subjects (HSs) were recruited (age and gender-matched). BDNF was measured from serum samples of patients and HSs and the data of body composition parameters were recorded. Additionally, both patients and HSs were asked to fill in questionnaires related to pain intensity, anxiety, and depression. Results: Our results highlight that the levels of both free and total BDNF are significantly lower in pain patients compared to HSs, with p values of 0.041 and 0.024, respectively. The number of CD3− CD56bright natural killer (NK) cells shows significant differences between the groups. Comparing all chronic pain patients with HSs reveals a significantly lower number of CD4+ CD8+ T cells (p = 0.031), CD3− CD56bright NK cells (p = 0.049) and CD20+ CD3− cells (p = 0.007). Conclusions: To conclude, it seems that a general conformity between the pathomechanisms of different chronic pain diseases exists, although there are unique findings only in specific chronic pain patients.

scholarly journals Predictive factors of high societal costs among chronic low back pain patients

2019 ◽  
Vol 24 (2) ◽  
pp. 325-337 ◽  
Author(s):  
Elizabeth N. Mutubuki ◽  
Mariette A. Luitjens ◽  
Esther T. Maas ◽  
Frank J. P. M. Huygen ◽  
Raymond W. J. G. Ostelo ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Predictive Factors ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Societal Costs ◽  
Pain Patients

Changes in paravertebral EMG spectrum parallel to strength increases after rehabilitation in chronic low back pain patients

1995 ◽  
Vol 9 (4) ◽  
pp. 354-362 ◽  
Author(s):  
Paolo Capodaglio ◽  
Jan Nilsson ◽  
Daniela H Jurisic
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Emg Spectrum ◽  
Pain Patients

scholarly journals Relative mobility of the pelvis and spine during trunk axial rotation in chronic low back pain patients: A case-control study

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0186369 ◽  
Author(s):  
Masashi Taniguchi ◽  
Hiroshige Tateuchi ◽  
Satoko Ibuki ◽  
Noriaki Ichihashi
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Case Control Study ◽  
Axial Rotation ◽  
Case Control ◽  
Low Back ◽  
Relative Mobility ◽  
Pain Patients ◽  
Control Study
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