scholarly journals Continuous Lymphoid Cell Lines with Characteristics of B Cells (Bone-Marrow-Derived), Lacking the Epstein-Barr Virus Genome and Derived from Three Human Lymphomas

1974 ◽  
Vol 71 (8) ◽  
pp. 3283-3286 ◽  
Author(s):  
G. Klein ◽  
T. Lindahl ◽  
M. Jondal ◽  
W. Leibold ◽  
J. Menezes ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Cell Lines ◽  
Lymphoid Cell ◽  
Epstein Barr Virus ◽  
Virus Genome ◽  
Barr Virus ◽  
Epstein Barr ◽  
Lymphoid Cell Lines

scholarly journals Epstein-Barr virus transformation of human pre-B cells.

1983 ◽  
Vol 158 (2) ◽  
pp. 616-622 ◽  
Author(s):  
M Hansson ◽  
K Falk ◽  
I Ernberg
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
B Cell ◽  
Cell Lines ◽  
Epstein Barr Virus ◽  
Bone Marrow Cells ◽  
Fetal Bone ◽  
Barr Virus ◽  
Epstein Barr

In vitro infection of human B lymphocytes with Epstein-Barr virus (EBV) results in establishment of B lymphoblastoid cell lines that reflect normal B cell phenotypes. In this study we have investigated whether immature B cells from fetal bone marrow and liver can serve as targets for EBV. The fetal bone marrow cells were readily transformed by EBV. Among the resulting cell lines, five were surface Ig (sIg)-negative. Three B cell-associated antigens defined by monoclonal antibodies were expressed to the same extent on the fetal cell lines, whether they belonged to the sIg- or sIg+ group. The various differentiation stages that these cell lines may represent are discussed.

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