scholarly journals Mitochondrial DNA polymorphism: evidence that variants detected by restriction enzymes differ in nucleotide sequence rather than in methylation.

1980 ◽  
Vol 77 (11) ◽  
pp. 6415-6419 ◽  
Author(s):  
F. J. Castora ◽  
N. Arnheim ◽  
M. V. Simpson
Keyword(s):  
Mitochondrial Dna ◽  
Nucleotide Sequence ◽  
Dna Polymorphism ◽  
Restriction Enzymes ◽  
Mitochondrial Dna Polymorphism

Mitochondrial DNA polymorphism detected with the restriction enzymes BstNI and BclI in a French Canadian population

1989 ◽  
Vol 53 (4) ◽  
pp. 319-325 ◽  
Author(s):  
Y. GÉLINAS ◽  
L. TURCOTTE ◽  
C. BOUCHANRD ◽  
M-C. THIBAULT ◽  
F. T. DIONNE
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymorphism ◽  
Restriction Enzymes ◽  
French Canadian ◽  
Mitochondrial Dna Polymorphism ◽  
Canadian Population

scholarly journals Intraspecific mitochondrial DNA polymorphism within the emerging filamentous fungal pathogen Trichoderma longibrachiatum

2006 ◽  
Vol 55 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Zsuzsanna Antal ◽  
János Varga ◽  
László Kredics ◽  
András Szekeres ◽  
Lóránt Hatvani ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Fungal Pathogen ◽  
Internal Transcribed Spacer ◽  
Dna Polymorphism ◽  
Restriction Enzymes ◽  
Clinical Isolates ◽  
Trichoderma Longibrachiatum ◽  
Mitochondrial Dna Polymorphism ◽  
Mitochondrial Dnas ◽  
Dna Profiles

The genetic diversity of the emerging fungal pathogen Trichoderma longibrachiatum was examined at the level of mitochondrial DNA. The 17 investigated strains, comprising nine clinical and eight non-clinical isolates, exhibited seven and ten different mitochondrial DNA profiles by using the restriction enzymes BsuRI and Hin6I, respectively. The sizes of mitochondrial DNAs varied from 34·9 to 39·5 kb. The discriminatory power of the method was higher than that of internal transcribed spacer sequence analysis and therefore should be more suitable for identification and epidemiological investigations. However, clinical and non-clinical isolates did not form separate clusters on the resulting dendrogram and thus there was no indication of a correlation between genetic structure and pathogenicity of the isolates.

Genetic analysis of Y chromosome and mitochondrial DNA polymorphism of Mulam ethnic group in Guangxi, China

2013 ◽  
Vol 35 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Xiao-Qing WANG ◽  
Chuan-Chao WANG ◽  
Qiong-Ying DENG ◽  
Hui LI
Keyword(s):  
Mitochondrial Dna ◽  
Genetic Analysis ◽  
Ethnic Group ◽  
Y Chromosome ◽  
Dna Polymorphism ◽  
Mitochondrial Dna Polymorphism

scholarly journals Mitochondrial DNA polymorphism in Japanese living in Hokkaido

1986 ◽  
Vol 31 (2) ◽  
pp. 73-83 ◽  
Author(s):  
Shinji Harihara ◽  
Momoki Hirai ◽  
Keiichi Omoto
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymorphism ◽  
Mitochondrial Dna Polymorphism

scholarly journals Mitochondrial DNA polymorphism and cardiovascular continuum diseases

2018 ◽  
pp. 9-13
Author(s):  
М.В. Голубенко ◽  
Р.Р. Салахов ◽  
Т.В. Шумакова ◽  
С.В. Буйкин ◽  
О.А. Макеева ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Cardiovascular Diseases ◽  
Mitochondrial Genome ◽  
Dna Polymorphism ◽  
Nuclear Genome ◽  
Published Data ◽  
Human Populations ◽  
Mitochondrial Dna Polymorphism ◽  
Polymorphism Level ◽  
Cardiovascular Continuum

Митохондриальный геном кодирует жизненно важные белки субъединиц дыхательной цепи и характеризуется высоким уровнем полиморфизма в популяциях человека. Однако работы по поиску генов предрасположенности к многофакторным заболеваниям, в том числе сердечно-сосудистым, часто ограничиваются анализом ядерного генома. В то же время показано, что отдельные генотипы мтДНК могут отличаться более высокой или низкой эффективностью окислительного фосфорилирования. Выявлены ассоциации популяционного полиморфизма мтДНК с сердечно-сосудистыми заболеваниями. Согласно результатам наших исследований, а также опубликованных другими авторами результатам ассоциативных и функциональных исследований, можно говорить о том, что эффект полиморфизма мтДНК проявляется чаще не в предрасположенности к сердечно-сосудистым заболеваниям в целом, а в риске развития осложнений и коморбидных фенотипов в пределах синтропии сердечно-сосудистого континуума. Mitochondrial genome, encoding respiratory chain subunits, is characterized by high polymorphism level in human populations. In most studies for susceptibility genes for common diseases, including cardiovascular diseases, the analysis is limited to the nuclear genome. It was shown that particular mtDNA genotypes may differ by oxidative phosphorylation efficiency. Some associations of mtDNA polymorphisms with cardiovascular diseases have been found. According to our results and published data, we suggest that mtDNA effect on cardiovascular system does not manifest in predisposition to cardiovascular diseases themselves but rather in risk of complications and comorbidities in the cardiovascular continuum.

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