“Les gens qui vous ressemblent”: Discursive Negotiation of Identity and Construction of Affiliation in the 2019 Canadian Federal Election Party Leader Debates

In the weeks leading up to the Canadian federal election, federal party leaders seek to appeal to a crucial part of the electorate - Québec voters, most of whom are of French-Canadian background - through a series of televised debates. As party leaders engage in discourse aimed at creating proximity with and enacting an affiliative stance toward these voters, the debates become a platform for discursive negotiation of Québec identity, in which identity stances and narratives are reflected, reproduced, and challenged. This study examines a corpus of party leaders’ discourse as these political actors interactively negotiate Québec identity during three party leader debates in the 2019 federal election. Following the theoretical framework of Critical Discourse Analysis, the inquiry discusses the following aspects of the party leaders’ discourse: discursive representation of Quebecers’ group identity and self-positioning with respect to that identity, use of symbolic lexis and references that signal attachment to the French-Canadian majority’s collective memory, and self-positioning with respect to the French language. In addition, the discussion addresses implications of the bilingual nature of political discourse in the Canadian context, focusing on party leaders’ use of code-switching and metapragmatic commentary. Crucially, the study’s conclusions suggest that a shared vision of Québec identity has not yet been widely ratified. While the party leaders’ discourse appears largely felicitous with the inclusive, civic vision of Québec identity, the study’s findings point to continued primacy of the French-Canadian fact in its current conceptualization.

A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene

Background Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants in other DNA repair pathway genes. Methods Whole exome sequencing was used to identify rare variants in HR genes in a BRCA1 and BRCA2 pathogenic variant negative OC family of French Canadian (FC) ancestry, a population exhibiting genetic drift. OC cases and cancer-free individuals from FC and non-FC populations were investigated for carrier frequency of FANCI c.1813C>T; p.L605F, the top-ranking candidate. Gene and protein expression were investigated in cancer cell lines and tissue microarrays, respectively. Results In FC subjects, c.1813C>T was more common in familial (7.1%, 3/42) than sporadic (1.6%, 7/439) OC cases (P = 0.048). Carriers were detected in 2.5% (74/2950) of cancer-free females though female/male carriers were more likely to have a first-degree relative with OC (121/5249, 2.3%; Spearman correlation = 0.037; P = 0.011), suggesting a role in risk. Many of the cancer-free females had host factors known to reduce risk to OC which could influence cancer risk in this population. There was an increased carrier frequency of FANCI c.1813C>T in BRCA1 and BRCA2 pathogenic variant negative OC families, when including the discovery family, compared to cancer-free females (3/23, 13%; OR = 5.8; 95%CI = 1.7–19; P = 0.005). In non-FC subjects, 10 candidate FANCI variants were identified in 4.1% (21/516) of Australian OC cases negative for pathogenic variants in BRCA1 and BRCA2, including 10 carriers of FANCI c.1813C>T. Candidate variants were significantly more common in familial OC than in sporadic OC (P = 0.04). Localization of FANCD2, part of the FANCI-FANCD2 (ID2) binding complex in the Fanconi anaemia (FA) pathway, to sites of induced DNA damage was severely impeded in cells expressing the p.L605F isoform. This isoform was expressed at a reduced level, destabilized by DNA damaging agent treatment in both HeLa and OC cell lines, and exhibited sensitivity to cisplatin but not to a poly (ADP-ribose) polymerase inhibitor. By tissue microarray analyses, FANCI protein was consistently expressed in fallopian tube epithelial cells and only expressed at low-to-moderate levels in 88% (83/94) of OC samples. Conclusions This is the first study to describe candidate OC variants in FANCI, a member of the ID2 complex of the FA DNA repair pathway. Our data suggest that pathogenic FANCI variants may modify OC risk in cancer families.

Picture Description of the Western Aphasia Battery Picnic Scene: Reference Data for the French Canadian Population

Purpose The main aim of this study is to provide French Canadian reference data for quantitative measures extracted from connected speech samples elicited by the Western Aphasia Battery–Revised picnic scene, a discourse task frequently used in clinical assessment of acquired language disorders. Method Our sample consisted of 62 healthy French Canadian adults divided in two age groups: a 50- to 69-year-old group and a 70- to 90-year-old group. Results High interrater reliability scores were obtained for most of the variables. Most connected speech variables did not demonstrate an age effect. However, the 70- to 90-year-old group produced more repetitions than the 50- to 69-year-old group and displayed reduced communication efficiency (number of information content units per minute). Conclusion These findings contribute to building a reference data set to analyze descriptive discourse production in clinical settings.

Représentation du handicap et changement de paradigme dans deux romans canadiens contemporains

We propose, in this article, to use a sociopoetic approach, in order to identify the representations of disability through various characters in two contemporary French-Canadian novels. We have studied the poetical processes at work, and especially how the authors use artistic creation and production, in order to question and overturn the existing prejudices dehumanizing people with disabilities. In both novels, Homme invisible à la fenêtre by Monique Proulx (1993) and Un jour ils entendront mes silences by Marie-Josée Martin (2012), the literary discourse constitutes a radical questioning of how disability is perceived, of how and why people with disabilities are being dehumanized, medicalised, and of our understanding of what constitutes “able” and “disabled”.

Bacteriophages: The Good Side of the Viruses

Bacteriophages or phages are bacterial viruses that are known to invade bacterial cells and, in the case of the lytic phages, impair bacterial metabolism, causing them to lyse. Since the discovery of these microorganisms by Felix d’Herelle, a French-Canadian microbiologist who worked at Institut Pasteur in Paris, Bacteriophages begin to be used in the treatment of human diseases, like dysentery and staphylococcal skin disease. However, due to the controversial efficacy of phage preparations, and with the advent of antibiotics, commercial production of therapeutic phage preparations ceased in most of the Western world. Nevertheless, phages continued to be used as therapeutic agents (together with or instead of antibiotics) in Eastern Europe and in the former Soviet Union. Therefore, there is a sufficient body of data that incite the accomplishment of further studies in the field of phage therapy.

In the Company of My Peers: Implementation of RDA in Canada

Describes the progress made toward implementing <i>Resource Description and Access</i> (RDA) in libraries across Canada, as of Fall 2013. Differences in the training experiences in the English-speaking cataloging communities and French-speaking cataloging communities are discussed. Preliminary results of a survey of implementation in English-Canadian libraries are included as well as a summary of the support provided for French-Canadian libraries. Data analysis includes an examination of the rate of adoption in Canada by region and by sector. Challenges in RDA training delivery in a Canadian context are identified, as well as opportunities for improvement and expansion of RDA training in the future.

In the Company of My Peers: Implementation of RDA in Canada

Describes the progress made toward implementing <i>Resource Description and Access</i> (RDA) in libraries across Canada, as of Fall 2013. Differences in the training experiences in the English-speaking cataloging communities and French-speaking cataloging communities are discussed. Preliminary results of a survey of implementation in English-Canadian libraries are included as well as a summary of the support provided for French-Canadian libraries. Data analysis includes an examination of the rate of adoption in Canada by region and by sector. Challenges in RDA training delivery in a Canadian context are identified, as well as opportunities for improvement and expansion of RDA training in the future.