scholarly journals Cell cycle regulation of dihydrofolate reductase mRNA metabolism in mouse fibroblasts.

1980 ◽  
Vol 77 (9) ◽  
pp. 5140-5144 ◽  
Author(s):  
S. L. Hendrickson ◽  
J. S. Wu ◽  
L. F. Johnson
Keyword(s):  
Cell Cycle ◽  
Dihydrofolate Reductase ◽  
Cell Cycle Regulation ◽  
Mouse Fibroblasts ◽  
Mrna Metabolism ◽  
Reductase Mrna ◽  
Cycle Regulation

scholarly journals Cell cycle regulation of thymidylate synthetase gene expression in cultured mouse fibroblasts.

1980 ◽  
Vol 255 (15) ◽  
pp. 7386-7390
Author(s):  
L.G. Navalgund ◽  
C. Rossana ◽  
A.J. Muench ◽  
L.F. Johnson
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Thymidylate Synthetase ◽  
Mouse Fibroblasts ◽  
Cycle Regulation

Murine dihydrofolate reductase transcripts through the cell cycle

1986 ◽  
Vol 6 (2) ◽  
pp. 365-371
Author(s):  
P J Farnham ◽  
R T Schimke
Keyword(s):  
Cell Cycle ◽  
Dihydrofolate Reductase ◽  
Transcription Initiation ◽  
Untranslated Region ◽  
Cell Cycle Regulation ◽  
Leader Sequence ◽  
Reductase Gene ◽  
Opposite Strand ◽  
Polyadenylation Sites ◽  
Cycle Regulation

The murine dihydrofolate reductase gene codes for mRNAs that differ in the length of their 3' untranslated region as well as in the length of their 5' leader sequence. In addition, the dihydrofolate reductase promoter functions bidirectionally, producing a series of RNAs from the opposite strand than the dihydrofolate reductase mRNAs. We have examined the production of these RNAs and their heterogeneous 5' and 3' termini as mouse 3T6 cells progress through a physiologically continuous cell cycle. We found that all of the transcripts traverse the cell cycle in a similar manner, increasing at the G1/S boundary without significantly changing their ratios relative to one another. We conclude that cell-cycle regulation of dihydrofolate reductase is achieved without recruiting new transcription initiation sites and without a change in polyadenylation sites. It appears that the mechanism responsible for the transcriptional cell-cycle regulation of the dihydrofolate reductase gene is manifested only by transiently increasing the efficiency of transcription at the dihydrofolate reductase promoter.

scholarly journals Murine dihydrofolate reductase transcripts through the cell cycle.

1986 ◽  
Vol 6 (2) ◽  
pp. 365-371 ◽  
Author(s):  
P J Farnham ◽  
R T Schimke
Keyword(s):  
Cell Cycle ◽  
Dihydrofolate Reductase ◽  
Transcription Initiation ◽  
Untranslated Region ◽  
Cell Cycle Regulation ◽  
Leader Sequence ◽  
Reductase Gene ◽  
Opposite Strand ◽  
Polyadenylation Sites ◽  
Cycle Regulation

The murine dihydrofolate reductase gene codes for mRNAs that differ in the length of their 3' untranslated region as well as in the length of their 5' leader sequence. In addition, the dihydrofolate reductase promoter functions bidirectionally, producing a series of RNAs from the opposite strand than the dihydrofolate reductase mRNAs. We have examined the production of these RNAs and their heterogeneous 5' and 3' termini as mouse 3T6 cells progress through a physiologically continuous cell cycle. We found that all of the transcripts traverse the cell cycle in a similar manner, increasing at the G1/S boundary without significantly changing their ratios relative to one another. We conclude that cell-cycle regulation of dihydrofolate reductase is achieved without recruiting new transcription initiation sites and without a change in polyadenylation sites. It appears that the mechanism responsible for the transcriptional cell-cycle regulation of the dihydrofolate reductase gene is manifested only by transiently increasing the efficiency of transcription at the dihydrofolate reductase promoter.

scholarly journals Cell Cycle Regulation of Deoxyribonucleoside Kinase Activities in Cultured Mouse Fibroblasts.

1988 ◽  
Vol 42b ◽  
pp. 122-124
Author(s):  
Aster Habteyesus ◽  
Staffan Eriksson ◽  
Jon Songstad ◽  
Lars Ernster ◽  
Harri Lönnberg ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Mouse Fibroblasts ◽  
Cycle Regulation

Role of pRB dephosphorylation in cell cycle regulation

10.2741/a501 ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. d121-137 ◽  
Author(s):  
John W Ludlow
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Cycle Regulation
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