Correction: Molecular Basis of Adult-Onset and Chronic GM2 Gangliosidoses in Patients of Ashkenazi Jewish Origin: Substitution of Serine for Glycine at Position 269 of the a-Subunit of p-Hexosaminidase

Lonar Lake, an Indian Soda Lake, is well known for its biodiversity of extremophiles including alkaliphiles. Most of the molecular studies on Lonar Lake alkaliphiles are based on molecular identification by 16S ribosomal RNA along with numerous applications in the biotechnology industry. However, molecular basis of adaptation of these alkaliphiles to high alkaline conditions is incompletely understood. Attempts were made to isolate and identify alkaliphiles from their naturally occurring original habitat, i.e. Lonar Lake, India with high alkaline conditions of pH 10.5. One facultative alkaliphile, Stenotrophomonas species DL18, was studied for F1FoATP synthase a-subunit with reference to alkaliphile-specific domains. Although the a-subunit of Stenotrophomonas DL18 showed significant similarity with neutrophiles, the isolated bacterium is an alkaliphile and optimally grows at pH 10.5.

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Ashkenazi Jewish Origin Protects Against Formation of Antibodies to Infliximab and Therapy Failure

Medicine ◽

10.1097/md.0000000000000673 ◽

2015 ◽

Vol 94 (18) ◽

pp. e673 ◽

Cited By ~ 14

Author(s):

Bella Ungar ◽

Ola Haj-Natour ◽

Uri Kopylov ◽

Miri Yavzori ◽

Ella Fudim ◽

...

Keyword(s):

Ashkenazi Jewish ◽

Therapy Failure ◽

Jewish Origin

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Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1714579115 ◽

2017 ◽

Vol 114 (52) ◽

pp. E11208-E11217 ◽

Cited By ~ 4

Author(s):

Takuya Kajitani ◽

Hiroaki Kato ◽

Yuji Chikashige ◽

Chihiro Tsutsumi ◽

Yasushi Hiraoka ◽

...

Keyword(s):

Rna Polymerase Ii ◽

Chromatin Structure ◽

Molecular Basis ◽

Rna Binding ◽

Noncoding Rnas ◽

Transcriptional Silencing ◽

Binding Activity ◽

Dependent Manner ◽

Heterochromatin Formation ◽

A Subunit

Some long noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (RNAPII) are retained on chromatin, where they regulate RNAi and chromatin structure. The molecular basis of this retention remains unknown. We show that in fission yeast serine 7 (Ser7) of the C-terminal domain (CTD) of RNAPII is required for efficient siRNA generation for RNAi-dependent heterochromatin formation. Surprisingly, Ser7 facilitates chromatin retention of nascent heterochromatic RNAs (hRNAs). Chromatin retention of hRNAs and siRNA generation requires both Ser7 and an RNA-binding activity of the chromodomain of Chp1, a subunit of the RNA-induced transcriptional silencing (RITS) complex. Furthermore, RITS associates with RNAPII in a Ser7-dependent manner. We propose that Ser7 promotes cotranscriptional chromatin retention of hRNA by recruiting the RNA-chromatin connector protein Chp1, which facilitates RNAi-dependent heterochromatin formation. Our findings reveal a function of the CTD code: linking ncRNA transcription to RNAi for heterochromatin formation.

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