scholarly journals p70 lupus autoantigen binds the enhancer of the T-cell receptor beta-chain gene.

1993 ◽  
Vol 90 (7) ◽  
pp. 2685-2689 ◽  
Author(s):  
H. Messier ◽  
T. Fuller ◽  
S. Mangal ◽  
H. Brickner ◽  
S. Igarashi ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Beta Chain ◽  
T Cell Receptor Beta ◽  
Receptor Beta

scholarly journals A Ki-1 (CD30)-positive human cell line (Karpas 299) established from a high-grade non-Hodgkin's lymphoma, showing a 2;5 translocation and rearrangement of the T-cell receptor beta-chain gene

Blood ◽  
1988 ◽  
Vol 72 (1) ◽  
pp. 234-240 ◽  
Author(s):  
P Fischer ◽  
E Nacheva ◽  
DY Mason ◽  
PD Sherrington ◽  
C Hoyle ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Line ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Human Cell Line ◽  
Chain Gene ◽  
Beta Chain ◽  
T Cell Receptor Beta ◽  
Blast Cells ◽  
Receptor Beta

We describe the characterization of a new human cell line, Karpas 299 (K299), established from blast cells in the peripheral blood of a 25- year-old white man. His illness, which began with enlarged occipital and axillary nodes and weight loss, ended after 7 months with generalized lymphadenopathy, pleural effusion, and bone marrow involvement. A lymph node biopsy showed a large cell lymphoma mainly sinusoidal in distribution. The blast cells with pleomorphic nuclei resembled primitive histiocytes. The cells, which expressed the T-cell- associated markers CD4 and CD5, were positive for HLA-DR, epithelial membrane antigen, and CD30 (Ki-1 antigen). The karyotype was aneuploid and included a translocation 2;5. The site of translocation on chromosome 5 (at 5q35.1) is in the region of the locus of the c-fms oncogene (receptor of the monocyte-macrophage colony-stimulating factor MCSF or CSF-1). The cell line Karpas 299 has the same karyotype and pattern of antigen expression as the patient's cells. Northern blot analysis of RNA showed an active rearrangement of the T-cell receptor beta-chain gene. This is to our knowledge the first Ki-1 antigen- positive line to be established from a case of non-Hodgkin's lymphoma.

Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction

2004 ◽  
Vol 200 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Robert E. Tillman ◽  
Andrea L. Wooley ◽  
Maureen M. Hughes ◽  
Bernard Khor ◽  
Barry P. Sleckman
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Beta Chain ◽  
Gene Assembly ◽  
T Cell Receptor Beta ◽  
Receptor Beta

A large deletion within the T-cell receptor beta-chain gene complex in New Zealand white mice

Science ◽  
1985 ◽  
Vol 229 (4709) ◽  
pp. 167-171 ◽  
Author(s):  
B. Kotzin ◽  
V. Barr ◽  
E Palmer
Keyword(s):  
New Zealand ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Large Deletion ◽  
Chain Gene ◽  
Gene Complex ◽  
Beta Chain ◽  
T Cell Receptor Beta ◽  
Receptor Beta

Dominant T-Cell Receptor beta-Chain Gene Rearrangements Indicate Clonal Expansion in the Rheumatoid Joint

1990 ◽  
Vol 31 (1) ◽  
pp. 121-125 ◽  
Author(s):  
A. M. M. MILTENBURG ◽  
J. M. LAAR ◽  
M. R. DAHA ◽  
R. R. P. VRIES ◽  
P. J. ELSEN ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Clonal Expansion ◽  
Cell Receptor ◽  
Chain Gene ◽  
Gene Rearrangements ◽  
Beta Chain ◽  
T Cell Receptor Beta ◽  
Receptor Beta

scholarly journals T-Cell Receptor Beta-Chain Gene Polymorphism and the Prognosis of IgA Nephropathy in Japanese Patients

Nephron ◽  
1995 ◽  
Vol 70 (4) ◽  
pp. 502-503 ◽  
Author(s):  
Ryuji Nagasawa ◽  
Omasu Matsumura ◽  
Naoki Maruyama ◽  
Tetsuya Mitarai ◽  
Kazuo Isoda
Keyword(s):  
T Cell ◽  
Gene Polymorphism ◽  
Iga Nephropathy ◽  
T Cell Receptor ◽  
Japanese Patients ◽  
Cell Receptor ◽  
Chain Gene ◽  
Beta Chain ◽  
T Cell Receptor Beta ◽  
Receptor Beta

scholarly journals Unusual organization of the human T-cell receptor beta-chain gene complex is linked to recombination hotspots.

1993 ◽  
Vol 90 (11) ◽  
pp. 5026-5029 ◽  
Author(s):  
E. Seboun ◽  
L. Houghton ◽  
C. J. Hatem ◽  
R. Lincoln ◽  
S. L. Hauser
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Gene Complex ◽  
Beta Chain ◽  
Recombination Hotspots ◽  
Human T Cell ◽  
T Cell Receptor Beta ◽  
Receptor Beta
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