scholarly journals Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine.

1996 ◽  
Vol 93 (22) ◽  
pp. 12553-12558 ◽  
Author(s):  
S. Okuda ◽  
N. Nishiyama ◽  
H. Saito ◽  
H. Katsuki
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell

scholarly journals Low-DoseAronia melanocarpaConcentrate Attenuates Paraquat-Induced Neurotoxicity

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
A. J. Case ◽  
D. Agraz ◽  
I. M. Ahmad ◽  
M. C. Zimmerman
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Reactive Oxygen ◽  
High Dose ◽  
Low Doses ◽  
Oxygen Species ◽  
High Doses

Herbicides containing paraquat may contribute to the pathogenesis of neurodegenerative disorders such as Parkinson’s disease. Paraquat induces reactive oxygen species-mediated apoptosis in neurons, which is a primary mechanism behind its toxicity. We sought to test the effectiveness of a commercially available polyphenol-richAronia melanocarpa(aronia berry) concentrate in the amelioration of paraquat-induced neurotoxicity. Considering the abundance of antioxidants in aronia berries, we hypothesized that aronia berry concentrate attenuates the paraquat-induced increase in reactive oxygen species and protects against paraquat-mediated neuronal cell death. Using a neuronal cell culture model, we observed that low doses of aronia berry concentrate protected against paraquat-mediated neurotoxicity. Additionally, low doses of the concentrate attenuated the paraquat-induced increase in superoxide, hydrogen peroxide, and oxidized glutathione levels. Interestingly, high doses of aronia berry concentrate increased neuronal superoxide levels independent of paraquat, while at the same time decreasing hydrogen peroxide. Moreover, high-dose aronia berry concentrate potentiated paraquat-induced superoxide production and neuronal cell death. In summary, aronia berry concentrate at low doses restores the homeostatic redox environment of neurons treated with paraquat, while high doses exacerbate the imbalance leading to further cell death. Our findings support that moderate levels of aronia berry concentrate may prevent reactive oxygen species-mediated neurotoxicity.

Eucommia ulmoides Oliv. Bark. protects against hydrogen peroxide-induced neuronal cell death in SH-SY5Y cells

2012 ◽  
Vol 142 (2) ◽  
pp. 337-345 ◽  
Author(s):  
Seung-Hwan Kwon ◽  
Min-Jung Kim ◽  
Shi-Xun Ma ◽  
In-Jee You ◽  
Ji-Young Hwang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Eucommia Ulmoides

Targeting ninjurin 2 by miR-764 regulates hydrogen peroxide (H2O2)-induced neuronal cell death

2018 ◽  
Vol 505 (4) ◽  
pp. 1180-1188 ◽  
Author(s):  
Ding Jing ◽  
Li Yinzhu ◽  
Pang Jinjing ◽  
Liang Lishuang ◽  
Zhang Guozhuan
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell

scholarly journals GS28 Protects Neuronal Cell Death Induced by Hydrogen Peroxide under Glutathione-Depleted Condition

2011 ◽  
Vol 15 (3) ◽  
pp. 149 ◽  
Author(s):  
Hwa Ok Lee ◽  
Yu Jeong Byun ◽  
Kyung-Ok Cho ◽  
Seong Yun Kim ◽  
Seong-Beom Lee ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell

Hydrogen peroxide distribution and neuronal cell death in a rat hippocampal slice

2005 ◽  
Vol 108 (1-2) ◽  
pp. 746-750 ◽  
Author(s):  
Nahoko Kasai ◽  
Chunxi Han ◽  
Keiichi Torimitsu
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Hippocampal Slice ◽  
Neuronal Cell Death ◽  
Neuronal Cell

scholarly journals Protective effects of perilla oil and alpha linolenic acid on SH-SY5Y neuronal cell death induced by hydrogen peroxide

2018 ◽  
Vol 12 (2) ◽  
pp. 93 ◽  
Author(s):  
Ah Young Lee ◽  
Ji Myung Choi ◽  
Myoung Hee Lee ◽  
Jaemin Lee ◽  
Sanghyun Lee ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Linolenic Acid ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Protective Effects ◽  
Alpha Linolenic Acid ◽  
Perilla Oil

scholarly journals A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide

2006 ◽  
Vol 101 (1) ◽  
pp. 66-76 ◽  
Author(s):  
Shuji Kaneko ◽  
Seiko Kawakami ◽  
Yuji Hara ◽  
Minoru Wakamori ◽  
Etsuko Itoh ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Critical Role ◽  
Neuronal Cell Death ◽  
Neuronal Cell
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