scholarly journals Neuronal Nitric-oxide Synthase-, an Alternatively Spliced Isoform Expressed in Differentiated Skeletal Muscle

1996 ◽  
Vol 271 (19) ◽  
pp. 11204-11208 ◽  
Author(s):  
Francesca Silvagno ◽  
Houhui Xia ◽  
David S. Bredt
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Alternatively Spliced ◽  
Oxide Synthase

scholarly journals Alternatively spliced neuronal nitric oxide synthase mediates penile erection

2006 ◽  
Vol 103 (9) ◽  
pp. 3440-3443 ◽  
Author(s):  
K. J. Hurt ◽  
S. F. Sezen ◽  
H. C. Champion ◽  
J. K. Crone ◽  
M. A. Palese ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Penile Erection ◽  
Neuronal Nitric Oxide Synthase ◽  
Alternatively Spliced ◽  
Oxide Synthase

scholarly journals Skeletal muscle glucose uptake during treadmill exercise in neuronal nitric oxide synthase-μ knockout mice

2016 ◽  
Vol 310 (10) ◽  
pp. E838-E845 ◽  
Author(s):  
Yet Hoi Hong ◽  
Christine Yang ◽  
Andrew C. Betik ◽  
Robert S. Lee-Young ◽  
Glenn K. McConell
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Glucose Uptake ◽  
Neuronal Nitric Oxide Synthase ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Skeletal Muscle Contraction ◽  
Skeletal Muscle Glucose Uptake ◽  
Oxide Synthase

Nitric oxide influences intramuscular signaling that affects skeletal muscle glucose uptake during exercise. The role of the main NO-producing enzyme isoform activated during skeletal muscle contraction, neuronal nitric oxide synthase-μ (nNOSμ), in modulating glucose uptake has not been investigated in a physiological exercise model. In this study, conscious and unrestrained chronically catheterized nNOSμ+/+ and nNOSμ−/− mice either remained at rest or ran on a treadmill at 17 m/min for 30 min. Both groups of mice demonstrated similar exercise capacity during a maximal exercise test to exhaustion (17.7 ± 0.6 vs. 15.9 ± 0.9 min for nNOSμ+/+ and nNOSμ−/−, respectively, P > 0.05). Resting and exercise blood glucose levels were comparable between the genotypes. Very low levels of NOS activity were detected in skeletal muscle from nNOSμ−/− mice, and exercise increased NOS activity only in nNOSμ+/+ mice (4.4 ± 0.3 to 5.2 ± 0.4 pmol·mg−1·min−1, P < 0.05). Exercise significantly increased glucose uptake in gastrocnemius muscle (5- to 7-fold) and, surprisingly, more so in nNOSμ−/− than in nNOSμ+/+ mice ( P < 0.05). This is in parallel with a greater increase in AMPK phosphorylation during exercise in nNOSμ−/− mice. In conclusion, nNOSμ is not essential for skeletal muscle glucose uptake during exercise, and the higher skeletal muscle glucose uptake during exercise in nNOSμ−/− mice may be due to compensatory increases in AMPK activation.

Role of Neuronal Nitric Oxide Synthase in Modulating Microvascular and Contractile Function in Rat Skeletal Muscle

2011 ◽  
Vol 18 (6) ◽  
pp. 501-511 ◽  
Author(s):  
STEVEN W. COPP ◽  
DANIEL M. HIRAI ◽  
SCOTT K. FERGUSON ◽  
TIMOTHY I. MUSCH ◽  
DAVID C. POOLE
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Contractile Function ◽  
Neuronal Nitric Oxide Synthase ◽  
Rat Skeletal Muscle ◽  
Oxide Synthase

scholarly journals Translational Regulation of Human Neuronal Nitric-oxide Synthase by an Alternatively Spliced 5′-Untranslated Region Leader Exon

2002 ◽  
Vol 278 (1) ◽  
pp. 636-644 ◽  
Author(s):  
Derek C. Newton ◽  
Siân C. Bevan ◽  
Stephen Choi ◽  
G. Brett Robb ◽  
Adam Millar ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Untranslated Region ◽  
Translational Regulation ◽  
Neuronal Nitric Oxide Synthase ◽  
Alternatively Spliced ◽  
Oxide Synthase

scholarly journals Neuronal nitric oxide synthase mediates insulin- and oxidative stress-induced glucose uptake in skeletal muscle myotubes

2017 ◽  
Vol 110 ◽  
pp. 261-269 ◽  
Author(s):  
Dean L. Kellogg ◽  
Karen M. McCammon ◽  
Kathryn S. Hinchee-Rodriguez ◽  
Martin L. Adamo ◽  
Linda J. Roman
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Glucose Uptake ◽  
Neuronal Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
And Oxidative Stress

scholarly journals Up-regulation of the peroxiredoxin-6 related metabolism of reactive oxygen species in skeletal muscle of mice lacking neuronal nitric oxide synthase

2009 ◽  
Vol 587 (3) ◽  
pp. 655-668 ◽  
Author(s):  
Luis Da Silva-Azevedo ◽  
Sebastian Jähne ◽  
Christian Hoffmann ◽  
Daniel Stalder ◽  
Manfred Heller ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Reactive Oxygen ◽  
Neuronal Nitric Oxide Synthase ◽  
Oxygen Species ◽  
Peroxiredoxin 6 ◽  
Oxide Synthase
Sign in / Sign up

Export Citation Format

Share Document