scholarly journals An Interleukin-1β Converting Enzyme-like Protease Is a Key Component of Fas-mediated Apoptosis

1996 ◽  
Vol 271 (36) ◽  
pp. 21699-21702 ◽  
Author(s):  
Alison J. Darmon ◽  
R. Chris Bleackley
Keyword(s):  
Interleukin 1Β ◽  
Converting Enzyme

scholarly journals Stability and oligomeric equilibria of refolded interleukin-1β converting enzyme.

1997 ◽  
Vol 272 (2) ◽  
pp. 1412
Author(s):  
Robert V. Talanian ◽  
Luan C. Dang ◽  
Catherine R. Ferenz ◽  
Maria C. Hackett ◽  
John A. Mankovich ◽  
...  
Keyword(s):  
Interleukin 1Β ◽  
Converting Enzyme

Distinct interleukin-1β-converting enzyme family proteases mediate cisplatin- and staurosporine-induced apoptosis of mouse proximal tubule cells

Life Sciences ◽  
1998 ◽  
Vol 62 (12) ◽  
pp. 1125-1138 ◽  
Author(s):  
Kazuhito Fukuoka ◽  
Michio Takeda ◽  
Mami Kobayashi ◽  
Takako Osaki ◽  
Isao Shiratc ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Interleukin 1Β ◽  
Converting Enzyme ◽  
Proximal Tubule Cells ◽  
Enzyme Family ◽  
Tubule Cells ◽  
Induced Apoptosis

In vivo study of motoneuron death induced by nerve injury in mice deficient in the caspase 1/ interleukin-1β-converting enzyme

Neuroscience ◽  
2000 ◽  
Vol 98 (3) ◽  
pp. 573-583 ◽  
Author(s):  
F. de Bilbao ◽  
P. Giannakopoulos ◽  
A. Srinivasan ◽  
M. Dubois-Dauphin
Keyword(s):  
Nerve Injury ◽  
Interleukin 1Β ◽  
In Vivo Study ◽  
Converting Enzyme ◽  
Caspase 1

Angiotensin-converting enzyme inhibitor inhibits dehydration-enhanced fever induced by endotoxin in rats

2000 ◽  
Vol 279 (4) ◽  
pp. R1512-R1516 ◽  
Author(s):  
Tatsuo Watanabe ◽  
Makoto Hashimoto ◽  
Minoru Wada ◽  
Toshiaki Imoto ◽  
Michio Miyoshi ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Intravenous Injection ◽  
Enzyme Inhibitor ◽  
Interleukin 1Β ◽  
Bacterial Endotoxin ◽  
Ang Ii ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitor

It has been reported that a host develops a marked fever under dehydrated conditions compared with normally hydrated conditions (11). The present study was carried out to investigate whether ANG II is involved in the enhancement seen in dehydrated rats of the fever induced by bacterial endotoxin. The results showed that intravenous injection of bacterial endotoxin produced a fever in dehydrated rats (rats deprived of water for 24 h) that was significantly greater than that seen in normally hydrated rats. In contrast, dehydration had no effect on the fever induced by intravenous interleukin-1β (IL-1β). Under dehydrated conditions, the enhanced endotoxin-induced fever was significantly inhibited by the angiotensin-converting enzyme inhibitor lisinopril, but the IL-1β fever was not. These results suggest that the dehydration-induced enhancement of endotoxin fever is due, at least in part, to the action of ANG II, which elicits an increased production of pyrogenic cytokines such as IL-1.

α-((Tetronoyl)oxy)- and α-((tetramoyl)oxy)methyl ketone inhibitors of the interleukin-1β converting enzyme (ICE)

1997 ◽  
Vol 7 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Todd L. Graybill ◽  
Catherine P. Prouty ◽  
Gary J. Speier ◽  
Denton Hoyer ◽  
Roland E. Dolle ◽  
...  
Keyword(s):  
Methyl Ketone ◽  
Interleukin 1Β ◽  
Converting Enzyme
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