Mutational Analysis of the SRC Homology 2 Domain Protein-tyrosine Phosphatase Corkscrew

John D. Allard; Ronald Herbst; Pamela M. Carroll; Michael A. Simon

doi:10.1074/jbc.273.21.13129

Mutational Analysis of the SRC Homology 2 Domain Protein-tyrosine Phosphatase Corkscrew

Journal of Biological Chemistry ◽

10.1074/jbc.273.21.13129 ◽

1998 ◽

Vol 273 (21) ◽

pp. 13129-13135 ◽

Cited By ~ 19

Author(s):

John D. Allard ◽

Ronald Herbst ◽

Pamela M. Carroll ◽

Michael A. Simon

Keyword(s):

Protein Tyrosine Phosphatase ◽

Mutational Analysis ◽

Tyrosine Phosphatase ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Domain Protein ◽

Src Homology 2 Domain

Download Full-text

Mutational Analysis of the Mechanism of Negative Regulation by Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 of Phagocytosis in Macrophages

The Journal of Immunology ◽

10.4049/jimmunol.177.5.3123 ◽

2006 ◽

Vol 177 (5) ◽

pp. 3123-3132 ◽

Cited By ~ 9

Author(s):

Hiroshi Ikeda ◽

Hideki Okazawa ◽

Hiroshi Ohnishi ◽

Yoji Murata ◽

Per-Arne Oldenborg ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Mutational Analysis ◽

Tyrosine Phosphatase ◽

Negative Regulation ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Phosphatase Substrate

Download Full-text

Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2019.1634641 ◽

2019 ◽

Vol 38 (9) ◽

pp. 2509-2520 ◽

Cited By ~ 2

Author(s):

Wen-Shan Liu ◽

Rui-Rui Wang ◽

Wei-Ya Li ◽

Mei Rong ◽

Chi-Lu Liu ◽

...

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulation ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Dynamics Simulation ◽

Loss Of Function ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

Download Full-text

Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105384 ◽

2021 ◽

pp. 105384

Author(s):

Xiang-Dong Meng ◽

Li-Xin Gao ◽

Zhi-Jia Wang ◽

Bo Feng ◽

Chun Zhang ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Biological Evaluation ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Oxadiazole Derivatives ◽

Src Homology 2 Domain ◽

Synthesis And Biological Evaluation

Download Full-text

Inhibition of Src homology 2 domain containing protein tyrosine phosphatase as the possible mechanism of metformin-assisted amelioration of obesity induced insulin resistance in high fat diet fed C57BL/6J mice

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2017.04.012 ◽

2017 ◽

Vol 487 (1) ◽

pp. 54-61 ◽

Cited By ~ 5

Author(s):

Yadhu Sharma ◽

Samina Bashir ◽

Ansarullah ◽

Mohemmed Faraz Khan ◽

Altaf Ahmad ◽

...

Keyword(s):

Insulin Resistance ◽

Protein Tyrosine Phosphatase ◽

High Fat Diet ◽

Tyrosine Phosphatase ◽

High Fat ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

Download Full-text

Chicken Ig-Like Receptor B2, a Member of a Multigene Family, Is Mainly Expressed on B Lymphocytes, Recruits Both Src Homology 2 Domain Containing Protein Tyrosine Phosphatase (SHP)-1 and SHP-2, and Inhibits Proliferation

The Journal of Immunology ◽

10.4049/jimmunol.173.12.7385 ◽

2004 ◽

Vol 173 (12) ◽

pp. 7385-7393 ◽

Cited By ~ 29

Author(s):

Birgit C. Viertlboeck ◽

Richard P. M. A. Crooijmans ◽

Martien A. M. Groenen ◽

Thomas W. F. Göbel

Keyword(s):

B Lymphocytes ◽

Protein Tyrosine Phosphatase ◽

Multigene Family ◽

Tyrosine Phosphatase ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

Download Full-text

Cell surface expression of channel catfish leukocyte immune-type receptors (IpLITRs) and recruitment of both Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 and SHP-2

Developmental & Comparative Immunology ◽

10.1016/j.dci.2008.10.006 ◽

2009 ◽

Vol 33 (4) ◽

pp. 570-582 ◽

Cited By ~ 19

Author(s):

Benjamin C.S. Montgomery ◽

Jacqueline Mewes ◽

Chelsea Davidson ◽

Deborah N. Burshtyn ◽

James L. Stafford

Keyword(s):

Cell Surface ◽

Channel Catfish ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Surface Expression ◽

Cell Surface Expression ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

Download Full-text

Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Journal of Medicinal Chemistry ◽

10.1021/jm8002526 ◽

2008 ◽

Vol 51 (16) ◽

pp. 4948-4956 ◽

Cited By ~ 55

Author(s):

Harshani R. Lawrence ◽

Roberta Pireddu ◽

Liwei Chen ◽

Yunting Luo ◽

Shen-Shu Sung ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

Download Full-text

Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the induction of Langerhans cell maturation

European Journal of Immunology ◽

10.1002/eji.200635864 ◽

2006 ◽

Vol 36 (12) ◽

pp. 3216-3226 ◽

Cited By ~ 16

Author(s):

Atsushi Fukunaga ◽

Hiroshi Nagai ◽

Xijun Yu ◽

Shuntaro Oniki ◽

Hideki Okazawa ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Langerhans Cell ◽

Cell Maturation ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Phosphatase Substrate

Download Full-text

Regulation of macrophage nitric oxide production by the protein tyrosine phosphatase Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1)

Immunology ◽

10.1111/j.1365-2567.2008.02929.x ◽

2008 ◽

Vol 127 (1) ◽

pp. 123-133 ◽

Cited By ~ 37

Author(s):

Julie Blanchette ◽

Issa Abu-Dayyeh ◽

Kasra Hassani ◽

Lorie Whitcombe ◽

Martin Olivier

Keyword(s):

Nitric Oxide ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Nitric Oxide Production ◽

Phosphotyrosine Phosphatase ◽

Protein Tyrosine ◽

Oxide Production ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

Download Full-text

Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Promotes Inflammation and Accelerates Osteoarthritis by Activating β-Catenin

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2021.646386 ◽

2021 ◽

Vol 9 ◽

Author(s):

Tenghui Tao ◽

Danni Luo ◽

Chenghao Gao ◽

Hui Liu ◽

Zehua Lei ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Cartilage Degradation ◽

Mitogen Activated Protein Kinase ◽

Osteophyte Formation ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Primary Mouse ◽

Src Homology ◽

Src Homology 2 Domain

Osteoarthritis (OA) is a chronic articular disease characterized by cartilage degradation, subchondral bone remodeling and osteophyte formation. Src homology 2 domain-containing protein tyrosine phosphatase (SHP2) has not been fully investigated in the pathogenesis of OA. In this study, we found that SHP2 expression was significantly increased after interleukin-1β (IL-1β) treatment in primary mouse chondrocytes. Inhibition of SHP2 using siRNA reduced MMP3, MMP13 levels, but increased AGGRECAN, COL2A1, SOX9 expression in vitro. On the contrary, overexpression of SHP2 exerted the opposite results and promoted cartilage degradation. Mechanistically, SHP2 activated Wnt/β-catenin signaling possibly through directly binding to β-catenin. SHP2 also induced inflammation through activating Mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways. Our in vivo studies showed that SHP2 knockdown effectively delayed cartilage destruction and reduced osteophyte formation in the mouse model of OA induced by destabilization of the medial meniscus (DMM). Altogether, our study identifies that SHP2 is a novel and potential therapeutic target of OA.

Download Full-text