scholarly journals Correction: Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IκBα degradation

2020 ◽  
Vol 295 (26) ◽  
pp. 8869-8869
Author(s):  
Chunyang Li ◽  
Shuzhen Chen ◽  
Ping Yue ◽  
Xingming Deng ◽  
Sagar Lonial ◽  
...  
Keyword(s):  
Proteasome Inhibitor ◽  
Iκbα Degradation

scholarly journals Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IκBα Degradation

2010 ◽  
Vol 285 (21) ◽  
pp. 16096-16104 ◽  
Author(s):  
Chunyang Li ◽  
Shuzhen Chen ◽  
Ping Yue ◽  
Xingming Deng ◽  
Sagar Lonial ◽  
...  
Keyword(s):  
Proteasome Inhibitor ◽  
Iκbα Degradation

Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity

2017 ◽  
Author(s):  
Carolyn Bertozzi ◽  
Fred Tomlin ◽  
Ulla Gerling-Driessen ◽  
Yi-Chang Liu ◽  
Ryan Flynn ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Small Molecule ◽  
Proteasome Inhibitor ◽  
Activation Mechanism ◽  
Cancer Drugs ◽  
Small Molecule Library ◽  
Library Screen ◽  
In Cells

We discovered that the proteostasis modulating transcription factor Nrf1 requires cytosolic de-N-glycosylation by the N-glycanase NGly1 as part of its activation mechanism. Through a covalent small molecule library screen, we discovered an inhibitor of NGly1 that blocks Nrf1 activation in cells and potentiates the activity of proteasome inhibitor cancer drugs. The requirement of NGly1 for Nrf1 activity likely underlies several pathologies associated with a rare hereditary deficiency in NGly1.

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