scholarly journals Recognition of Polyadenosine RNA by the Zinc Finger Domain of Nuclear Poly(A) RNA-binding Protein 2 (Nab2) Is Required for Correct mRNA 3′-End Formation*

2010 ◽  
Vol 285 (34) ◽  
pp. 26022-26032 ◽  
Author(s):  
Seth M. Kelly ◽  
Sara W. Leung ◽  
Luciano H. Apponi ◽  
Anna M. Bramley ◽  
Elizabeth J. Tran ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Zinc Finger Domain

scholarly journals Structural Basis of the Disorder in the Tandem Zinc Finger Domain of the RNA-Binding Protein Tristetraprolin

2016 ◽  
Vol 12 (10) ◽  
pp. 4717-4725 ◽  
Author(s):  
Davide Tavella ◽  
Laura M. Deveau ◽  
Troy W. Whitfield ◽  
Francesca Massi
Keyword(s):  
Zinc Finger ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Structural Basis ◽  
Zinc Finger Domain ◽  
Tandem Zinc Finger

scholarly journals A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Thomas Pohlmann ◽  
Sebastian Baumann ◽  
Carl Haag ◽  
Mario Albrecht ◽  
Michael Feldbrügge
Keyword(s):  
Zinc Finger ◽  
Membrane Trafficking ◽  
Molecular Motors ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Detailed Knowledge ◽  
Zinc Finger Domain ◽  
Domain Protein ◽  
Dependent Transport

An emerging theme in cellular logistics is the close connection between mRNA and membrane trafficking. A prominent example is the microtubule-dependent transport of mRNAs and associated ribosomes on endosomes. This coordinated process is crucial for correct septin filamentation and efficient growth of polarised cells, such as fungal hyphae. Despite detailed knowledge on the key RNA-binding protein and the molecular motors involved, it is unclear how mRNAs are connected to membranes during transport. Here, we identify a novel factor containing a FYVE zinc finger domain for interaction with endosomal lipids and a new PAM2-like domain required for interaction with the MLLE domain of the key RNA-binding protein. Consistently, loss of this FYVE domain protein leads to specific defects in mRNA, ribosome, and septin transport without affecting general functions of endosomes or their movement. Hence, this is the first endosomal component specific for mRNP trafficking uncovering a new mechanism to couple mRNPs to endosomes.

scholarly journals A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length

RNA ◽  
2014 ◽  
Vol 20 (5) ◽  
pp. 681-688 ◽  
Author(s):  
Seth M. Kelly ◽  
Sara W. Leung ◽  
ChangHui Pak ◽  
Ayan Banerjee ◽  
Kenneth H. Moberg ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Tail Length

scholarly journals The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA

2016 ◽  
Vol 291 (43) ◽  
pp. 22442-22459 ◽  
Author(s):  
Callie P. Wigington ◽  
Kevin J. Morris ◽  
Laura E. Newman ◽  
Anita H. Corbett
Keyword(s):  
Zinc Finger ◽  
Atp Synthase ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Mrna Processing ◽  
Subunit Mrna

scholarly journals Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein

Gene ◽  
2009 ◽  
Vol 439 (1-2) ◽  
pp. 71-78 ◽  
Author(s):  
Sara W. Leung ◽  
Luciano H. Apponi ◽  
Omar E. Cornejo ◽  
Chad M. Kitchen ◽  
Sandro R. Valentini ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Rna Binding ◽  
Splice Variants ◽  
Binding Protein ◽  
Rna Binding Protein

scholarly journals Xenopus laevis zygote arrest 2 (zar2) encodes a zinc finger RNA-binding protein that binds to the translational control sequence in the maternal Wee1 mRNA and regulates translation

2012 ◽  
Vol 369 (2) ◽  
pp. 177-190 ◽  
Author(s):  
Amanda Charlesworth ◽  
Tomomi M. Yamamoto ◽  
Jonathan M. Cook ◽  
Kevin D. Silva ◽  
Cassandra V. Kotter ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Zinc Finger ◽  
Translational Control ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Control Sequence
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