scholarly journals Human Rhinovirus Selectively Modulates Membranous and Soluble Forms of Its Intercellular Adhesion Molecule–1 (ICAM-1) Receptor to Promote Epithelial Cell Infectivity

2003 ◽  
Vol 278 (14) ◽  
pp. 11954-11961 ◽  
Author(s):  
Suzanne C. Whiteman ◽  
Andrea Bianco ◽  
Richard A. Knight ◽  
Monica A. Spiteri
Keyword(s):  
Epithelial Cell ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Human Rhinovirus ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1

scholarly journals Interleukin-1α Released from Epithelial Cells after Adenovirus Type 37 Infection Activates Intercellular Adhesion Molecule 1 Expression on Human Vascular Endothelial Cells

2002 ◽  
Vol 76 (1) ◽  
pp. 427-431 ◽  
Author(s):  
Cheng-Hsien Chang ◽  
Yan Huang ◽  
Andrew C. Issekutz ◽  
May Griffith ◽  
Kuei-Hsiang Lin ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Adhesion Molecule ◽  
Umbilical Vein ◽  
Adenovirus Type ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Interleukin 1Α

ABSTRACT A key event in virus-induced inflammation (leukocyte extravasation through the endothelium) is the local activation of endothelial cells, as indicated by the expression of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. In order to identify triggers of inflammation in adenovirus infection, we inoculated respiratory and ocular epithelial cells with adenovirus type 37 (Ad37), a human pathogen associated with keratoconjunctivitis as well as urogenital and respiratory infections. Fluids from virus-infected epithelial cells activated ICAM-1 (and to a lesser extent, VCAM-1) expression on cultured human umbilical vein endothelial cells. Blocking studies with anticytokine antibodies implicated interleukin-1α (IL-1α) as the epithelial cell-derived factor which activated endothelial cell ICAM-1 expression. The results thus identify epithelial cell-derived IL-1α as a potentially important activator of endothelial cells in Ad37-induced inflammation.

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