Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance

Journal of Biological Chemistry ◽

10.1074/jbc.m305796200 ◽

2003 ◽

Vol 279 (3) ◽

pp. 1810-1818 ◽

Author(s):

Jay P. McLaughlin ◽

Lisa C. Myers ◽

Paul E. Zarek ◽

Marc G. Caron ◽

Robert J. Lefkowitz ◽

...

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Receptor Kinase ◽

Kappa Opioid ◽

Receptor Phosphorylation ◽

Analgesic Tolerance ◽

Protein Receptor

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Faculty Opinions recommendation of Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016246.200307 ◽

2003 ◽

Author(s):

Eric Nestler

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Receptor Kinase ◽

Kappa Opioid ◽

Receptor Phosphorylation ◽

Analgesic Tolerance ◽

Protein Receptor

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The G protein-biased kappa opioid receptor agonist 6′-GNTI blocks hippocampal paroxysmal discharges without inducing aversion

Intrinsic Activity ◽

10.25006/ia.3.s2-a2.14 ◽

2015 ◽

Vol 3 (Suppl. 2) ◽

pp. A2.14

Author(s):

Luca Zangrandi

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Receptor Agonist ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Opioid Receptor Agonist

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Faculty Opinions recommendation of G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1017245.202414 ◽

2004 ◽

Author(s):

Mark von Zastrow

Keyword(s):

G Protein ◽

Opioid Analgesic ◽

Opioid Withdrawal ◽

Receptor Kinase ◽

Analgesic Tolerance ◽

Protein Receptor

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Regulator of G Protein Signaling-12 (RGS12) in dopaminergic and kappa opioid receptor-dependent signaling and behavior

10.33915/etd.4060 ◽

2019 ◽

Author(s):

Joshua David Gross

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

G Protein Signaling ◽

Protein Signaling ◽

Kappa Opioid ◽

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Agonist-dependent Desensitization of the κ Opioid Receptor by G Protein Receptor Kinase and β-Arrestin

Journal of Biological Chemistry ◽

10.1074/jbc.274.34.23802 ◽

1999 ◽

Vol 274 (34) ◽

pp. 23802-23807 ◽

Author(s):

Suzanne M. Appleyard ◽

Jeremy Celver ◽

Victor Pineda ◽

Abraham Kovoor ◽

Gary A. Wayman ◽

...

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Receptor Kinase ◽

Protein Receptor

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Identification of G Protein-Coupled Receptor Kinase 2 Phosphorylation Sites Responsible for Agonist-Stimulated δ-Opioid Receptor Phosphorylation

Molecular Pharmacology ◽

10.1124/mol.58.5.1050 ◽

2000 ◽

Vol 58 (5) ◽

pp. 1050-1056 ◽

Author(s):

Jun Guo ◽

Yalan Wu ◽

Wenbo Zhang ◽

Jing Zhao ◽

Lakshmi A. Devi ◽

...

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Phosphorylation Sites ◽

Receptor Kinase ◽

G Protein Coupled Receptor ◽

Receptor Phosphorylation ◽

Δ Opioid Receptor ◽

G Protein Coupled

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Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.5b00092 ◽

2015 ◽

Vol 6 (8) ◽

pp. 1411-1419 ◽

Author(s):

Kimberly M. Lovell ◽

Kevin J. Frankowski ◽

Edward L. Stahl ◽

Stephen R. Slauson ◽

Euna Yoo ◽

...

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Structure Activity Relationship ◽

Kappa Opioid Receptor ◽

Activity Relationship ◽

Kappa Opioid ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Activation of G-protein and c-Jun N-terminal kinase by kappa opioid receptor ligands

Drug and Alcohol Dependence ◽

10.1016/j.drugalcdep.2014.02.306 ◽

2014 ◽

Vol 140 ◽

pp. e106

Author(s):

B.I. Knapp ◽

Jean M. Bidlack

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Kappa Opioid Receptor ◽

Receptor Ligands ◽

Kappa Opioid ◽

Opioid Receptor Ligands

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Characterization of the kappa opioid receptor‐mediated G protein signaling in mouse striatum using a [ 35 S]GTPγS binding assay (659.6)

The FASEB Journal ◽

10.1096/fasebj.28.1_supplement.659.6 ◽

2014 ◽

Vol 28 (S1) ◽

Author(s):

Lei Zhou ◽

Edward Stahl ◽

Kimberly Lovell ◽

Stephen Slauson ◽

Kevin Frankowski ◽

...

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Binding Assay ◽

Kappa Opioid Receptor ◽

G Protein Signaling ◽

Protein Signaling ◽

Kappa Opioid ◽

Mouse Striatum ◽

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The kappa-opioid receptor from human placenta: Hydrodynamic characteristics and evidence for its association with A G protein

Life Sciences ◽

10.1016/0024-3205(88)90159-2 ◽

1988 ◽

Vol 43 (6) ◽

pp. 559-567 ◽

Author(s):

G. Porthé ◽

B. Francés ◽

B. Vertier ◽

J. Cros ◽

J.-C. Meunier

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Human Placenta ◽

Kappa Opioid Receptor ◽

Hydrodynamic Characteristics ◽

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