Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression

David A. Bloom; Anil K. Jaiswal

doi:10.1074/jbc.m307633200

Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression

Journal of Biological Chemistry ◽

10.1074/jbc.m307633200 ◽

2003 ◽

Vol 278 (45) ◽

pp. 44675-44682 ◽

Cited By ~ 345

Author(s):

David A. Bloom ◽

Anil K. Jaiswal

Keyword(s):

Gene Expression ◽

Protein Kinase C ◽

Protein Kinase ◽

Transcriptional Activation ◽

Antioxidant Response ◽

Antioxidant Response Element ◽

Response Element ◽

Kinase C

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Role of protein kinase C δ in curcumin-induced antioxidant response element-mediated gene expression in human monocytes

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2006.01.065 ◽

2006 ◽

Vol 341 (4) ◽

pp. 1007-1016 ◽

Cited By ~ 126

Author(s):

Stuart A. Rushworth ◽

Richard M. Ogborne ◽

Charles A. Charalambos ◽

Maria A. O’Connell

Keyword(s):

Gene Expression ◽

Protein Kinase C ◽

Protein Kinase ◽

Antioxidant Response ◽

Antioxidant Response Element ◽

Human Monocytes ◽

Response Element ◽

Kinase C

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Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.220418997 ◽

2000 ◽

Vol 97 (23) ◽

pp. 12475-12480 ◽

Cited By ~ 365

Author(s):

H.-C. Huang ◽

T. Nguyen ◽

C. B. Pickett

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Antioxidant Response ◽

Related Factor ◽

Antioxidant Response Element ◽

Response Element ◽

Kinase C

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Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription

Journal of Biological Chemistry ◽

10.1074/jbc.m206911200 ◽

2002 ◽

Vol 277 (45) ◽

pp. 42769-42774 ◽

Cited By ~ 648

Author(s):

H.-C. Huang ◽

Truyen Nguyen ◽

Cecil B. Pickett

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Antioxidant Response ◽

Antioxidant Response Element ◽

Response Element ◽

Kinase C

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Functional divergence of protein kinase C (PKC) family members. PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)52986-0 ◽

1993 ◽

Vol 268 (12) ◽

pp. 9122-9129

Author(s):

A. Hata ◽

Y. Akita ◽

K. Suzuki ◽

S. Ohno

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Transcriptional Activation ◽

Functional Divergence ◽

Family Members ◽

Response Element ◽

Kinase C ◽

Pkc Alpha

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Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism

Journal of Biological Chemistry ◽

10.1074/jbc.m004037200 ◽

2000 ◽

Vol 275 (51) ◽

pp. 39907-39913 ◽

Cited By ~ 264

Author(s):

Rong Yu ◽

Chi Chen ◽

Yin-Yuan Mo ◽

Vidya Hebbar ◽

Edward D. Owuor ◽

...

Keyword(s):

Gene Expression ◽

Protein Kinase ◽

Antioxidant Response ◽

Mitogen Activated Protein Kinase ◽

Antioxidant Response Element ◽

Response Element ◽

Mitogen Activated Protein ◽

Dependent Mechanism

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LY290181, an Inhibitor of Diabetes-Induced Vascular Dysfunction, Blocks Protein Kinase C--Stimulated Transcriptional Activation Through Inhibition of Transcription Factor Binding to a Phorbol Response Element

Diabetes ◽

10.2337/diab.45.5.642 ◽

1996 ◽

Vol 45 (5) ◽

pp. 642-650 ◽

Cited By ~ 23

Author(s):

K. A. Birch ◽

W. F. Heath ◽

R. N. Hermeling ◽

C. M. Johnston ◽

L. Stramm ◽

...

Keyword(s):

Transcription Factor ◽

Protein Kinase C ◽

Protein Kinase ◽

Transcriptional Activation ◽

Vascular Dysfunction ◽

Transcription Factor Binding ◽

Response Element ◽

Factor Binding ◽

Kinase C

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LY290181, an inhibitor of diabetes-induced vascular dysfunction, blocks protein kinase C-stimulated transcriptional activation through inhibition of transcription factor binding to a phorbol response element

Diabetes ◽

10.2337/diabetes.45.5.642 ◽

1996 ◽

Vol 45 (5) ◽

pp. 642-650 ◽

Cited By ~ 4

Author(s):

K. A. Birch ◽

W. F. Heath ◽

R. N. Hermeling ◽

C. M. Johnston ◽

L. Stramm ◽

...

Keyword(s):

Transcription Factor ◽

Protein Kinase C ◽

Protein Kinase ◽

Transcriptional Activation ◽

Vascular Dysfunction ◽

Transcription Factor Binding ◽

Response Element ◽

Factor Binding ◽

Kinase C

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Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes

Cancer Letters ◽

10.1016/j.canlet.2005.12.023 ◽

2006 ◽

Vol 244 (2) ◽

pp. 220-228 ◽

Cited By ~ 8

Author(s):

Ming Zhu ◽

Yuesheng Zhang ◽

G. Tim Bowden

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Protein Kinases ◽

Human Keratinocytes ◽

Antioxidant Response ◽

Antioxidant Response Element ◽

Mitogen Activated Protein Kinases ◽

Kinase C ◽

Mitogen Activated Protein ◽

Element Activity

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Faculty Opinions recommendation of Protein kinase C delta phosphorylates ecdysone receptor B1 to promote gene expression and apoptosis under 20-hydroxyecdysone regulation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.728367419.793536652 ◽

2017 ◽

Author(s):

Kang Le

Keyword(s):

Gene Expression ◽

Protein Kinase C ◽

Protein Kinase ◽

Ecdysone Receptor ◽

Protein Kinase C Delta ◽

Kinase C

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Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase requires protein kinase C activation.

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)40074-4 ◽

1994 ◽

Vol 35 (8) ◽

pp. 1413-1421

Author(s):

G Reiner ◽

M Oliver ◽

E Skamene ◽

D Radzioch

Keyword(s):

Gene Expression ◽

Protein Kinase C ◽

Protein Kinase ◽

Tumor Necrosis ◽

Necrosis Factor Alpha ◽

Kinase C ◽

Factor Alpha ◽

Alpha Gene ◽

Protein Kinase C Activation ◽

Necrosis Factor

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