scholarly journals CD40 Signaling through a Newly Identified Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2) Binding Site

2003 ◽  
Vol 278 (46) ◽  
pp. 45414-45418 ◽  
Author(s):  
Li-Fan Lu ◽  
W. James Cook ◽  
Ling-Li Lin ◽  
Randolph J. Noelle
Keyword(s):  
Tumor Necrosis Factor ◽  
Binding Site ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Associated Factor ◽  
Necrosis Factor

scholarly journals CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency

2004 ◽  
Vol 78 (11) ◽  
pp. 6055-6060 ◽  
Author(s):  
Kathy A. Green ◽  
Cory L. Ahonen ◽  
W. James Cook ◽  
William R. Green
Keyword(s):  
Tumor Necrosis Factor ◽  
Binding Site ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Associated Factor ◽  
Disease Induction ◽  
Necrosis Factor

ABSTRACT LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.

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