CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency
2004 ◽
Vol 78
(11)
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pp. 6055-6060
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Keyword(s):
ABSTRACT LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
2003 ◽
Vol 278
(46)
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pp. 45414-45418
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2005 ◽
Vol 280
(36)
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pp. 31572-31581
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2013 ◽
Vol 288
(30)
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pp. 21784-21792
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2013 ◽
Vol 40
(8)
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pp. 4769-4779
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2003 ◽
Vol 278
(38)
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pp. 36334-36340
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