scholarly journals Nuclear Factor of Activated T Cells and Serum Response Factor Cooperatively Regulate the Activity of an α-Actin Intronic Enhancer

2005 ◽  
Vol 280 (28) ◽  
pp. 26113-26120 ◽  
Author(s):  
Laura V. Gonzalez Bosc ◽  
Jeff J. Layne ◽  
Mark T. Nelson ◽  
David C. Hill-Eubanks
Keyword(s):  
T Cells ◽  
Serum Response Factor ◽  
Response Factor ◽  
Nuclear Factor ◽  
Activated T Cells ◽  
Intronic Enhancer ◽  
Serum Response

scholarly journals Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip

2012 ◽  
Vol 10 (1) ◽  
pp. 5 ◽  
Author(s):  
Kristin Katsch ◽  
Sarah de Jong ◽  
Jens-Christian Albrecht ◽  
Julia Steger ◽  
Harald Genth ◽  
...  
Keyword(s):  
T Cells ◽  
Serum Response Factor ◽  
Response Factor ◽  
Viral Oncoprotein ◽  
Serum Response

Interaction between NF-kappa B- and serum response factor-binding elements activates an interleukin-2 receptor alpha-chain enhancer specifically in T lymphocytes

1993 ◽  
Vol 13 (4) ◽  
pp. 2536-2545
Author(s):  
A A Kuang ◽  
K D Novak ◽  
S M Kang ◽  
K Bruhn ◽  
M J Lenardo
Keyword(s):  
T Cells ◽  
Serum Response Factor ◽  
Interleukin 2 ◽  
Response Factor ◽  
Nf Kappa B ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Interleukin 2 Receptor ◽  
Serum Response ◽  
Receptor Alpha Chain

We find that a short enhancer element containing the NF-kappa B binding site from the interleukin-2 receptor alpha-chain gene (IL-2R alpha) is preferentially activated in T cells. The IL-2R alpha enhancer binds NF-kappa B poorly and is only weakly activated by the NF-kappa B site alone. Serum response factor (SRF) binds to a site adjacent to the NF-kappa B site in the IL-2R enhancer, and both sites together have strong transcriptional activity specifically in T cells. Surprisingly, the levels of SRF constitutively expressed in T cells are consistently higher than in other cell types. Overexpression of SRF in B cells causes the IL-2R enhancer to function as well as it does in T cells, suggesting that the high level of SRF binding in T cells is functionally important.

scholarly journals Interaction between NF-kappa B- and serum response factor-binding elements activates an interleukin-2 receptor alpha-chain enhancer specifically in T lymphocytes.

1993 ◽  
Vol 13 (4) ◽  
pp. 2536-2545 ◽  
Author(s):  
A A Kuang ◽  
K D Novak ◽  
S M Kang ◽  
K Bruhn ◽  
M J Lenardo
Keyword(s):  
T Cells ◽  
Serum Response Factor ◽  
Interleukin 2 ◽  
Response Factor ◽  
Nf Kappa B ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Interleukin 2 Receptor ◽  
Serum Response ◽  
Receptor Alpha Chain

We find that a short enhancer element containing the NF-kappa B binding site from the interleukin-2 receptor alpha-chain gene (IL-2R alpha) is preferentially activated in T cells. The IL-2R alpha enhancer binds NF-kappa B poorly and is only weakly activated by the NF-kappa B site alone. Serum response factor (SRF) binds to a site adjacent to the NF-kappa B site in the IL-2R enhancer, and both sites together have strong transcriptional activity specifically in T cells. Surprisingly, the levels of SRF constitutively expressed in T cells are consistently higher than in other cell types. Overexpression of SRF in B cells causes the IL-2R enhancer to function as well as it does in T cells, suggesting that the high level of SRF binding in T cells is functionally important.

scholarly journals Co-Activation of Nuclear Factor-κB and Myocardin/Serum Response Factor Conveys the Hypertrophy Signal of High Insulin Levels in Cardiac Myoblasts

2014 ◽  
Vol 289 (28) ◽  
pp. 19585-19598 ◽  
Author(s):  
Rosalinda Madonna ◽  
Yong-Jian Geng ◽  
Roberto Bolli ◽  
Gregg Rokosh ◽  
Peter Ferdinandy ◽  
...  
Keyword(s):  
Serum Response Factor ◽  
Nuclear Factor Κb ◽  
Response Factor ◽  
Nuclear Factor ◽  
Insulin Levels ◽  
Co Activation ◽  
High Insulin ◽  
Cardiac Myoblasts ◽  
Serum Response
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