scholarly journals The Second Intracellular Loop of the Calcitonin Gene-related Peptide Receptor Provides Molecular Determinants for Signal Transduction and Cell Surface Expression

2005 ◽  
Vol 281 (3) ◽  
pp. 1644-1651 ◽  
Author(s):  
Alex C. Conner ◽  
John Simms ◽  
Stephen G. Howitt ◽  
Mark Wheatley ◽  
David R. Poyner
Keyword(s):  
Signal Transduction ◽  
Cell Surface ◽  
Surface Expression ◽  
Calcitonin Gene Related Peptide ◽  
Cell Surface Expression ◽  
Intracellular Loop ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Molecular Determinants

The activation of the CGRP receptor

2013 ◽  
Vol 41 (1) ◽  
pp. 180-184 ◽  
Author(s):  
James Barwell ◽  
Mark Wheatley ◽  
Alex C. Conner ◽  
Bruck Taddese ◽  
Shabana Vohra ◽  
...  
Keyword(s):  
Cell Surface ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
Accessory Protein ◽  
Calcitonin Receptor ◽  
Cgrp Receptor ◽  
Peptide Receptor ◽  
Calcitonin Gene ◽  
New Knowledge ◽  
G Protein Coupled

The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

2010 ◽  
Vol 333 (1) ◽  
pp. 152-160 ◽  
Author(s):  
Christopher A. Salvatore ◽  
Eric L. Moore ◽  
Amy Calamari ◽  
Jacquelynn J. Cook ◽  
Maria S. Michener ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Calcitonin Gene Related Peptide ◽  
Pharmacological Properties ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Orally Active
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