The activation of the CGRP receptor
2013 ◽
Vol 41
(1)
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pp. 180-184
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Keyword(s):
The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.
2005 ◽
Vol 281
(3)
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pp. 1644-1651
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2012 ◽
Vol 40
(2)
◽
pp. 433-437
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2005 ◽
Vol 16
(12)
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pp. 5572-5578
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2016 ◽
Vol 36
(7)
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pp. 1152-1163
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2013 ◽
Vol 24
(11)
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pp. 1649-1660
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Keyword(s):
2021 ◽
2020 ◽
Vol 117
(6)
◽
pp. 2957-2967