scholarly journals A Cation-regulated and Proton Gradient-dependent Cation Transporter fromChlamydomonas reinhardtiiHas a Role in Calcium and Sodium Homeostasis

2008 ◽  
Vol 284 (1) ◽  
pp. 525-533 ◽  
Author(s):  
Jon K. Pittman ◽  
Clare Edmond ◽  
Paul A. Sunderland ◽  
Clifford M. Bray
Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 727
Author(s):  
Natalia Słabiak-Błaż ◽  
Grzegorz Piecha

The role of endogenous mammalian cardiotonic steroids (CTS) in the physiology and pathophysiology of the cardiovascular system and the kidneys has interested researchers for more than 20 years. Cardiotonic steroids extracted from toads or plants, such as digitalis, have been used to treat heart disease since ancient times. CTS, also called endogenous digitalis-like factors, take part in the regulation of blood pressure and sodium homeostasis through their effects on the transport enzyme called sodium–potassium adenosine triphosphatase (Na/K-ATPase) in renal and cardiovascular tissue. In recent years, there has been increasing evidence showing deleterious effects of CTS on the structure and function of the heart, vasculature and kidneys. Understanding the role of CTS may be useful in the development of potential new therapeutic strategies.


FEBS Letters ◽  
1974 ◽  
Vol 49 (2) ◽  
pp. 203-207 ◽  
Author(s):  
Rita Casadio ◽  
Assunta Baccarini Melandri ◽  
Davide Zannoni ◽  
Bruno A. Melandri

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