Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+Stores in Insulin-stimulated Insulin Secretion in β-Cells

Craig A. Aspinwall; Wei-Jun Qian; Michael G. Roper; Rohit N. Kulkarni; C. Ronald Kahn; Robert T. Kennedy

doi:10.1074/jbc.m909647199

Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+Stores in Insulin-stimulated Insulin Secretion in β-Cells

Journal of Biological Chemistry ◽

10.1074/jbc.m909647199 ◽

2000 ◽

Vol 275 (29) ◽

pp. 22331-22338 ◽

Cited By ~ 125

Author(s):

Craig A. Aspinwall ◽

Wei-Jun Qian ◽

Michael G. Roper ◽

Rohit N. Kulkarni ◽

C. Ronald Kahn ◽

...

Keyword(s):

Insulin Secretion ◽

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Β Cells ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Persistent Activation of Phosphatidylinositol 3-Kinase Causes Insulin Resistance Due to Accelerated Insulin-Induced Insulin Receptor Substrate-1 Degradation in 3T3-L1 Adipocytes*

Endocrinology ◽

10.1210/endo.141.6.7516 ◽

2000 ◽

Vol 141 (6) ◽

pp. 1930-1935 ◽

Cited By ~ 27

Author(s):

Katsuya Egawa ◽

Naoki Nakashima ◽

Prem M. Sharma ◽

Hiroshi Maegawa ◽

Yoshio Nagai ◽

...

Keyword(s):

Insulin Resistance ◽

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Platelet-derived Growth Factor Inhibits Insulin Stimulation of Insulin Receptor Substrate-1-associated Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes without Affecting Glucose Transport

Journal of Biological Chemistry ◽

10.1074/jbc.273.39.25139 ◽

1998 ◽

Vol 273 (39) ◽

pp. 25139-25147 ◽

Cited By ~ 67

Author(s):

Patricia A. Staubs ◽

James G. Nelson ◽

Donna R. Reichart ◽

Jerrold M. Olefsky

Keyword(s):

Growth Factor ◽

Insulin Receptor ◽

Glucose Transport ◽

Platelet Derived Growth Factor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Stimulation ◽

Insulin Receptor Substrate 1 ◽

Stimulation Of ◽

Phosphatidylinositol 3

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Insulin-induced egr-1 and c-fos expression in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and phosphatidylinositol 3-kinase activation.

Journal of Biological Chemistry ◽

10.1074/s0021-9258(19)67421-1 ◽

2001 ◽

Vol 272 (5) ◽

pp. 3124

Author(s):

Shuko Harada ◽

Robert M. Smith ◽

Judith A. Smith ◽

Morris F. White ◽

Leonard Jarett

Keyword(s):

Protein Kinase ◽

Insulin Receptor ◽

Mitogen Activated Protein Kinase ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Kinase Activation ◽

Mitogen Activated Protein ◽

Fos Expression ◽

Phosphatidylinositol 3

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Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1

Molecular Endocrinology ◽

10.1210/me.9.4.435 ◽

1995 ◽

Vol 9 (4) ◽

pp. 435-442 ◽

Cited By ~ 6

Author(s):

V. Sanchez-Margalet

Keyword(s):

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Adaptor Molecule ◽

Phosphatidylinositol 3

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Insulin-stimulated cell growth in insulin receptor substrate-1–deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase–independent pathway

Journal of Cellular Biochemistry ◽

10.1002/(sici)1097-4644(19980801)70:2<268::aid-jcb12>3.0.co;2-j ◽

1998 ◽

Vol 70 (2) ◽

pp. 268-280 ◽

Cited By ~ 20

Author(s):

Biancamaria Gliozzo ◽

Chin K. Sung ◽

PierLuigi Scalia ◽

Vincenzo Papa ◽

Francesco Frasca ◽

...

Keyword(s):

Cell Growth ◽

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Gastrin Stimulates Tyrosine Phosphorylation of Insulin Receptor Substrate 1 and Its Association with Grb2 and the Phosphatidylinositol 3-Kinase

Journal of Biological Chemistry ◽

10.1074/jbc.271.42.26356 ◽

1996 ◽

Vol 271 (42) ◽

pp. 26356-26361 ◽

Cited By ~ 60

Author(s):

Aline Kowalski-Chauvel ◽

Lucien Pradayrol ◽

Nicole Vaysse ◽

Catherine Seva

Keyword(s):

Insulin Receptor ◽

Tyrosine Phosphorylation ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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SH3 domain of the phosphatidylinositol 3-kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2007.10.187 ◽

2008 ◽

Vol 365 (3) ◽

pp. 433-438 ◽

Cited By ~ 2

Author(s):

Yuichi Ikegami ◽

Kouichi Inukai ◽

Takuya Awata ◽

Tomoichiro Asano ◽

Shigehiro Katayama

Keyword(s):

Insulin Receptor ◽

Sh3 Domain ◽

Regulatory Subunit ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone

Molecular Endocrinology ◽

10.1210/me.8.5.545 ◽

1994 ◽

Vol 8 (5) ◽

pp. 545-557 ◽

Cited By ~ 19

Author(s):

M. J. Saad

Keyword(s):

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase

Journal of Biological Chemistry ◽

10.1074/jbc.270.27.15938 ◽

1995 ◽

Vol 270 (27) ◽

pp. 15938-15941 ◽

Cited By ~ 138

Author(s):

Shahab Uddin ◽

Lynne Yenush ◽

Xiao-Jian Sun ◽

Michelle E. Sweet ◽

Morris F. White ◽

...

Keyword(s):

Insulin Receptor ◽

Interferon Α ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Leptin-Induced IL-6 Production Is Mediated by Leptin Receptor, Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, Akt, NF-κB, and p300 Pathway in Microglia

The Journal of Immunology ◽

10.4049/jimmunol.179.2.1292 ◽

2007 ◽

Vol 179 (2) ◽

pp. 1292-1302 ◽

Cited By ~ 101

Author(s):

Chih-Hsin Tang ◽

Da-Yuu Lu ◽

Rong-Sen Yang ◽

Huei-Yann Tsai ◽

Ming-Ching Kao ◽

...

Keyword(s):

Insulin Receptor ◽

Leptin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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