scholarly journals Characterization of two engineered dimeric Zika virus envelope proteins as immunogens for neutralizing antibody selection and vaccine design

2019 ◽  
Vol 294 (27) ◽  
pp. 10638-10648 ◽  
Author(s):  
Chunpeng Yang ◽  
Fang Zeng ◽  
Xinyu Gao ◽  
Shaojuan Zhao ◽  
Xuan Li ◽  
...  
Keyword(s):  
Zika Virus ◽  
Vaccine Design ◽  
Neutralizing Antibody ◽  
Envelope Proteins ◽  
Virus Envelope

scholarly journals Antigenic and Functional Characterization Of Rinderpest Virus Envelope Proteins Using Monoclonal Antibodies

1991 ◽  
Vol 72 (8) ◽  
pp. 1863-1869 ◽  
Author(s):  
M. Sugiyama ◽  
N. Minamoto ◽  
T. Kinjo ◽  
N. Hirayama ◽  
K. Asano ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Functional Characterization ◽  
Envelope Proteins ◽  
Rinderpest Virus ◽  
Virus Envelope

scholarly journals Characterization of Simian-Human Immunodeficiency Virus Envelope Glycoprotein Epitopes Recognized by Neutralizing Antibodies from Infected Monkeys

1998 ◽  
Vol 72 (10) ◽  
pp. 8437-8445 ◽  
Author(s):  
Bijan Etemad-Moghadam ◽  
Gunilla B. Karlsson ◽  
Matilda Halloran ◽  
Ying Sun ◽  
Dominik Schenten ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antibody Response ◽  
Envelope Glycoprotein ◽  
Neutralizing Antibodies ◽  
Neutralizing Antibody ◽  
Virus Envelope ◽  
Immunodeficiency Virus ◽  
Variable Loops

ABSTRACT We characterized human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein epitopes recognized by neutralizing antibodies from monkeys recently infected by molecularly cloned simian-human immunodeficiency virus (SHIV) variants. The early neutralizing antibody response in each infected animal was directed mainly against a single epitope. This primary neutralizing epitope, however, differed among individual monkeys infected by identical viruses. Two such neutralization epitopes were determined by sequences in the V2 and V3 loops of the gp120 envelope glycoprotein, while a third neutralization epitope, apparently discontinuous, was determined by both V2 and V3 sequences. These results indicate that the early neutralizing antibody response in SHIV-infected monkeys is monospecific and directed against epitopes composed of the gp120 V2 and V3 variable loops.

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