scholarly journals A Combined Proteomic and Transcriptomic Approach Shows Diverging Molecular Mechanisms in Thoracic Aortic Aneurysm Development in Patients with Tricuspid- And Bicuspid Aortic Valve

2012 ◽  
Vol 12 (2) ◽  
pp. 407-425 ◽  
Author(s):  
Sanela Kjellqvist ◽  
Shohreh Maleki ◽  
Therese Olsson ◽  
Maggy Chwastyniak ◽  
Rui Miguel Mamede Branca ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Aneurysm ◽  
Bicuspid Aortic Valve ◽  
Thoracic Aortic Aneurysm ◽  
Molecular Mechanisms ◽  
Aneurysm Development

Uptake of Screening and Recurrence of Bicuspid Aortic Valve and Thoracic Aortic Aneurysm Among At-Risk Siblings of Pediatric Probands

2021 ◽  
Author(s):  
Daniel Miller ◽  
Lisa J. Martin ◽  
Justin T. Tretter ◽  
James Cnota ◽  
Nicole Weaver ◽  
...  
Keyword(s):  
At Risk ◽  
Aortic Valve ◽  
Aortic Aneurysm ◽  
Bicuspid Aortic Valve ◽  
Thoracic Aortic Aneurysm

scholarly journals A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Carmela R. Balistreri ◽  
Silvio Buffa ◽  
Alberto Allegra ◽  
Calogera Pisano ◽  
Giovanni Ruvolo ◽  
...  
Keyword(s):  
B Cells ◽  
Aortic Valve ◽  
Aortic Aneurysm ◽  
Thoracic Aortic Aneurysm ◽  
Molecular Mechanisms ◽  
B Lymphocyte ◽  
Valve Disease ◽  
Tricuspid Aortic Valve ◽  
Bicuspid Valve ◽  
Circulating Levels

Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated the circulating levels of T and B lymphocyte subsets associated with the development of vascular diseases in patients with bicuspid aortic valve or tricuspid aortic valve with and without thoracic aortic aneurysm. We unveiled that the circulating levels of the MAIT, CD4+IL−17A+, and NKT T cell subsets were significantly reduced in bicuspid valve disease cases, when compared to tricuspid aortic valve cases in either the presence or the absence of thoracic aortic aneurysm. Among patients with tricuspid aortic valve, these cells were higher in those also affected by thoracic aortic aneurysm. Similar data were obtained by examining CD19+ B cells, naïve B cells (IgD+CD27−), memory unswitched B cells (IgD+CD27+), memory switched B cells (IgD−CD27+), and double-negative B cells (DN) (IgD−CD27−). These cells resulted to be lower in subjects with bicuspid valve disease with respect to patients with tricuspid aortic valve. In whole, our data indicate that patients with bicuspid valve disease show a quantitative reduction of T and B lymphocyte cell subsets. Future studies are encouraged to understand the molecular mechanisms underlying this observation and its pathophysiological significance.

scholarly journals Thoracic Aortic Aneurysm Growth in Bicuspid Aortic Valve Patients: Role of Aortic Stiffness and Pulsatile Hemodynamics

2019 ◽  
Vol 8 (8) ◽  
Author(s):  
Jasjit Rooprai ◽  
Munir Boodhwani ◽  
Luc Beauchesne ◽  
Kwan‐Leung Chan ◽  
Carole Dennie ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Aneurysm ◽  
Bicuspid Aortic Valve ◽  
Aortic Stiffness ◽  
Thoracic Aortic Aneurysm ◽  
Aneurysm Growth

scholarly journals A novel SMAD6 variant in a patient with severely calcified bicuspid aortic valve and thoracic aortic aneurysm

2019 ◽  
Vol 7 (5) ◽  
pp. e620 ◽  
Author(s):  
Jong Eun Park ◽  
Jin Seok Park ◽  
Shin Yi Jang ◽  
Seok Hee Park ◽  
Jong‐Won Kim ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Aneurysm ◽  
Bicuspid Aortic Valve ◽  
Thoracic Aortic Aneurysm

Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm

2014 ◽  
Vol 92 (9) ◽  
pp. 939-949 ◽  
Author(s):  
Jiwon Lee ◽  
Mengcheng Shen ◽  
Nirmal Parajuli ◽  
Gavin Y. Oudit ◽  
Michael Sean McMurtry ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Aneurysm ◽  
Bicuspid Aortic Valve ◽  
Thoracic Aortic Aneurysm

scholarly journals Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor

2017 ◽  
Vol 8 ◽  
Author(s):  
Elisabeth Gillis ◽  
Ajay A. Kumar ◽  
Ilse Luyckx ◽  
Christoph Preuss ◽  
Elyssa Cannaerts ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Aneurysm ◽  
Candidate Gene ◽  
Bicuspid Aortic Valve ◽  
Thoracic Aortic Aneurysm ◽  
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