Atypical lipoma: Well-differentiated liposarcoma of the orbit with dedifferentiated areas

Orbit ◽  
2003 ◽  
Vol 22 (4) ◽  
pp. 311-316 ◽  
Author(s):  
Neda Stiglmayer ◽  
Sonja Jandrokovic ◽  
Pavle Miklic ◽  
Zdenka Hutinec
2017 ◽  
Vol 10 (2) ◽  
pp. 438-441 ◽  
Author(s):  
R.E. Shackelford ◽  
M. Al Shaarani ◽  
J. Ansari ◽  
E. Wei ◽  
J. Cotelingam

A 24-year-old woman presented with a 5-month history of a left flank mass that was painful on palpation. Magnetic resonance imaging revealed a 10.0 × 6.0 × 2.5 cm mass consistent with lipoma. A fatty lobulated mass was excised and subjected to H&E staining and immunohistochemical analyses. The specimen consisted of mature univacuolated adipocytic cells, with intermixed multivacuolated eosinophilic granular cells. No atypia or hyperchromasia was identified. Most of the cells were S100 positive and Ki-67 immunonegative. A diagnosis of a lipoma-like hibernoma was rendered. Hibernomas are rare benign lipomatous tumors that show differentiation toward brown fat. The lipoma-like hibernoma subtype is rare and can be misdiagnosed as atypical lipoma or well-differentiated liposarcoma. Here we describe an example of this rare tumor.


Author(s):  
Jorge S. Reis-Filho ◽  
João Cruz ◽  
Carmen Ruiz de Valbueva ◽  
Fernando C. Schmitt

Author(s):  
M. Lakshmi Narayana ◽  
S. M. Azeem Mohiyuddin ◽  
Vivek Viswambharan ◽  
Urvashi Gaur ◽  
G. Krishnamurthy Swethadri

<p class="abstract">The term atypical lipoma was introduced to describe the relatively benign course of well-differentiated liposarcomas when they occur in extremities compared to their retroperitoneal counterparts. A 32-year-old lady presented with dysphagia, excessive snoring and difficulty in breathing for three months<span>. On examination, a smooth globular retropharyngeal swelling was seen extending anteriorly till epiglottis obscuring the view of vocal cords. The CECT scan demonstrated features suggestive of a lipomatous lesion with possible sarcomatous change. Excision was done through a transcervical approach and histopathology showed features suggestive of atypical lipoma of retropharyngeal space</span>. As the tumor was removed in toto, adjuvant radiotherapy was not advised. Hence if any swelling in the retropharyngeal space is noted, the probability of soft tissue tumors must be ruled out by a CT/MRI scan before attempting incision and drainage or any other surgical procedure. Postoperative adjuvant radiotherapy is limited to high-grade tumors, incompletely excised tumors and more radiosensitive liposarcoma subtypes such as myxoid sarcomas.</p>


2004 ◽  
Vol 61 (5) ◽  
pp. 565-568 ◽  
Author(s):  
Zorica Stojsic ◽  
Dragoljub Bacetic ◽  
Bozina Radevic ◽  
Jovan Vasiljevic

Background. The coexistence of a well-differentiated liposarcoma (atypical lipomatous tumor) and benign smooth muscle component in a single soft tissue neoplasm is extremely rare. Case report. Histologic and immunohistochemical characteristics of tumor, which represented the reccurence of a retroperitoneal atypical lipoma in a 50-year-old female patient are presented in this paper. The tumor represented the recurrence of a retroperitoneal atypical lipoma. Lipomatous component consisted of a mixture of lipoma-like and sclerosing variant of well-differentiated liposarcoma. Characteristically, the heterologous smooth muscle differentiation was manifested as a macroscopically visible nodular growth in the form of a leiomyoma within the adipocytic component. It consisted of intersecting fascicles of spindle cells, which lacked mitoses and significant atypia, and were immunopositive for smooth muscle markers. Conclusion. This case of well-differentiated liposarcoma with benign smooth muscle is the first reported tumor of retroperitoneal localization. It is also the first one to exhibit the heterologous smooth muscle component as a distinct leiomyoma.


Author(s):  
E.C. Chew ◽  
C.L. Li ◽  
D.P. Huang ◽  
H.C. Ho ◽  
L.S. Mak ◽  
...  

An epithelial cell line, NPC/HK1, has recently been established from a biopsy specimen of a recurrent tumour of the nasopharynx which was histologically diagnosed as a moderately to well differentiated squamous cell carcinoma. A definite decrease in the amount of tonofilaments and desmosomes in the NPC/HK1 cells during the cell line establishment was observed. The present communication reports on the fine structures of the NPC/HK1 cells heterotraneplanted in athymic nude mice.


Sign in / Sign up

Export Citation Format

Share Document