Atypical lipoma, atypical intramuscular lipoma and well differentiated retroperitoneal liposarcoma

1980 ◽  
Vol 66 (2) ◽  
pp. 331
Author(s):  
Evans H. L ◽  
Soule E. H ◽  
Winkelmann R. K ◽  
Richard A. Mladick
Keyword(s):  
Retroperitoneal Liposarcoma ◽  
Intramuscular Lipoma ◽  
Atypical Lipoma ◽  
Well Differentiated

scholarly journals Retroperitoneal Liposarcoma Presenting as Bilateral Inguinal Hernias

2021 ◽  
Author(s):  
DO Haley S. Lehman ◽  
DO Ryan N. Qasawa ◽  
John J. Lim
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Mass Effect ◽  
Potential Space ◽  
Retroperitoneal Liposarcoma ◽  
Median Size ◽  
Inguinal Hernias ◽  
Retroperitoneal Tumors ◽  
Well Differentiated

Abstract Liposarcoma is one of the most common soft tissue sarcomas and has multiple subtypes, including atypical, well-differentiated, and dedifferentiated liposarcoma1. These tumors most commonly occur in the extremities and the retroperitoneum2, and account for 20% of all retroperitoneal tumors3. Retroperitoneal liposarcoma is very rare overall, occurring in 2.5 per one million people4. Patients will present from symptoms of mass effect due to the uncontrolled growth in the large potential space of the retroperitoneum, with its median size being around 30 cm5. The mainstay of treatment for this type of tumor is resection to a negative margin6. This is a case report describing a retroperitoneal liposarcoma presenting with bilateral inguinal hernias containing intraperitoneal fat from mass effect.

Retroperitoneal Liposarcoma With Combined Well-Differentiated and Myxoid Malignant Fibrous Histiocytoma–Like Myxoid Areas

1999 ◽  
Vol 23 (12) ◽  
pp. 1480 ◽  
Author(s):  
Masanori Hisaoka ◽  
Yosuke Morimitsu ◽  
Hiroshi Hashimoto ◽  
Tsuyoshi Ishida ◽  
Hiroyuki Mukai ◽  
...  
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Retroperitoneal Liposarcoma ◽  
Well Differentiated

scholarly journals Intramuscular lipoma: a review of the literature

2014 ◽  
Vol 6 (4) ◽  
Author(s):  
Shane McTighe ◽  
Ivan Chernev
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissue ◽  
Clinical Features ◽  
Common Type ◽  
Fatty Tissue ◽  
Review Of The Literature ◽  
Mesenchymal Tumors ◽  
Intramuscular Lipoma ◽  
Imaging Characteristics ◽  
Well Differentiated

Lipomas are the most common type of soft tissue mesenchymal tumors. They are typically located subcutaneously and consist of mature fatty tissue. When they occur under the enclosing fascia, they are called deep-seated lipomas. Infrequently, lipomas can arise inside the muscle and are called intramuscular lipomas. Intramuscular lipomas have been commonly investigated and categorized in the same group as other deep-seated and superficial lipomatous lesions. Their clinical, histological and imaging characteristics may resemble well-differentiated liposarcomas, further adding to the difficulties in the differential diagnosis. This article summarizes the available literature and describes the typical epidemiological, pathological and clinical features of intramuscular lipomas, as well as delineating their treatment and prognosis.

scholarly journals Analysis of the Intratumoral Adaptive Immune Response in Well Differentiated and Dedifferentiated Retroperitoneal Liposarcoma

Sarcoma ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
William W. Tseng ◽  
Shruti Malu ◽  
Minying Zhang ◽  
Jieqing Chen ◽  
Geok Choo Sim ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Cd8 T Cells ◽  
Immune Checkpoint ◽  
Cd4 T Cells ◽  
Immune Cell ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Retroperitoneal Liposarcoma ◽  
Well Differentiated

Treatment options are limited in well differentiated (WD) and dedifferentiated (DD) retroperitoneal liposarcoma. We sought to study the intratumoral adaptive immune response and explore the potential feasibility of immunotherapy in this disease. Tumor-infiltrating lymphocytes (TILs) were isolated from fresh surgical specimens and analyzed by flow cytometry for surface marker expression. Previously reported immune cell aggregates known as tertiary lymphoid structures (TLS) were further characterized by immunohistochemistry. In all fresh tumors, TILs were found. The majority of TILs were CD4 T cells; however cytotoxic CD8 T cells were also seen (average: 20% of CD3 T cells). Among CD8 T cells, 65% expressed the immune checkpoint molecule PD-1. Intratumoral TLS may be sites of antigen presentation as DC-LAMP positive, mature dendritic cells were found juxtaposed next to CD4 T cells. Clinicopathologic correlation, however, demonstrated that presence of TLS was associated with worse recurrence-free survival in WD disease and worse overall survival in DD disease. Our data suggest that an adaptive immune response is present in WD/DD retroperitoneal liposarcoma but may be hindered by TLS, among other possible microenvironmental factors; further investigation is needed. Immunotherapy, including immune checkpoint blockade, should be evaluated as a treatment option in this disease.

Atypical lipoma: Well-differentiated liposarcoma of the orbit with dedifferentiated areas

Orbit ◽  
2003 ◽  
Vol 22 (4) ◽  
pp. 311-316 ◽  
Author(s):  
Neda Stiglmayer ◽  
Sonja Jandrokovic ◽  
Pavle Miklic ◽  
Zdenka Hutinec
Keyword(s):  
Atypical Lipoma ◽  
Well Differentiated

Rare case of a giant well-differentiated retroperitoneal liposarcoma

2010 ◽  
Vol 63 ◽  
pp. 45-47
Author(s):  
Radosław Starownik ◽  
Krzysztof Bar ◽  
Jacek Kiś ◽  
Jerzy Michalak ◽  
Paweł Płaza
Keyword(s):  
Rare Case ◽  
Retroperitoneal Liposarcoma ◽  
Well Differentiated

Lymphocyte Composition and Distribution in Inflammatory, Well-differentiated Retroperitoneal Liposarcoma

2012 ◽  
Vol 36 (6) ◽  
pp. 941-944 ◽  
Author(s):  
William W. Tseng ◽  
Elizabeth G. Demicco ◽  
Alexander J. Lazar ◽  
Dina C. Lev ◽  
Raphael E. Pollock
Keyword(s):  
Retroperitoneal Liposarcoma ◽  
Well Differentiated

scholarly journals A Twenty-Four-Year-Old Woman with Left Flank Lipoma-Like Hibernoma

2017 ◽  
Vol 10 (2) ◽  
pp. 438-441 ◽  
Author(s):  
R.E. Shackelford ◽  
M. Al Shaarani ◽  
J. Ansari ◽  
E. Wei ◽  
J. Cotelingam
Keyword(s):  
Rare Tumor ◽  
Granular Cells ◽  
Resonance Imaging ◽  
Ki 67 ◽  
Left Flank ◽  
Atypical Lipoma ◽  
History Of ◽  
Well Differentiated ◽  
Immunohistochemical Analyses ◽  
Lipomatous Tumors

A 24-year-old woman presented with a 5-month history of a left flank mass that was painful on palpation. Magnetic resonance imaging revealed a 10.0 × 6.0 × 2.5 cm mass consistent with lipoma. A fatty lobulated mass was excised and subjected to H&E staining and immunohistochemical analyses. The specimen consisted of mature univacuolated adipocytic cells, with intermixed multivacuolated eosinophilic granular cells. No atypia or hyperchromasia was identified. Most of the cells were S100 positive and Ki-67 immunonegative. A diagnosis of a lipoma-like hibernoma was rendered. Hibernomas are rare benign lipomatous tumors that show differentiation toward brown fat. The lipoma-like hibernoma subtype is rare and can be misdiagnosed as atypical lipoma or well-differentiated liposarcoma. Here we describe an example of this rare tumor.

Sign in / Sign up

Export Citation Format

Share Document