Hibernoma of Thigh: A Case Report of 39-Year-Old Male

Introduction: Hibernoma is an uncommon benign lipomatous tumor that originates from residual brown fat. It commonly affects adult patients aged between 30 and 40 with a slight predominance in male more than female and usually seen in the thigh, shoulder, back, chest, axilla, and neck. The present report aimed to highlight on a viable differential diagnosis of thigh mass including liposarcoma and atypical lipoma. Case Presentation: This is the case report with detailed history, examination of 39-year-old male patient with hibernoma over medial aspect of thigh. Marginal surgical resection was carried and sent to histopathology to confirm the diagnosis of hibernoma. Conclusion: Hibernoma is a rare benign lipomatous soft tissue tumor with no known risk for malignant transformation or metastasis. Based on imaging examination, it can mimic malignant tumors such as, liposarcoma, in which we believe that biopsy is required in order to reach the diagnosis in most of the cases. Keywords: Soft tissue tumor, hibernoma, brown fat, liposarcoma.

A case report: a giant cardiac atypical lipoma associated with pericardium and right atrium

Background Among primary cardiac tumors, atypical lipoma is very rare. In particular, cases with lipomas in both the pericardium and the atria are even rare. Case presentation We report the case of a 49-year-old male patient presented to our department because of chest pain. Echocardiography revealed two large masses in both the pericardium and the right atrium. Then the tumors were completely resected and the histopathological examination revealed atypical lipoma. The patient recovered well without any complication and discharged from hospital. Conclusions We report a very rare case of a huge atypical lipomas located on the pericardium and right atrium. These tumors were easily detected by echocardiography and final diagnosed after surgical resection and pathological examination.

A rare case of atypical lipoma in retropharyngeal space and review of literature

<p class="abstract">The term atypical lipoma was introduced to describe the relatively benign course of well-differentiated liposarcomas when they occur in extremities compared to their retroperitoneal counterparts. A 32-year-old lady presented with dysphagia, excessive snoring and difficulty in breathing for three months<span>. On examination, a smooth globular retropharyngeal swelling was seen extending anteriorly till epiglottis obscuring the view of vocal cords. The CECT scan demonstrated features suggestive of a lipomatous lesion with possible sarcomatous change. Excision was done through a transcervical approach and histopathology showed features suggestive of atypical lipoma of retropharyngeal space</span>. As the tumor was removed in toto, adjuvant radiotherapy was not advised. Hence if any swelling in the retropharyngeal space is noted, the probability of soft tissue tumors must be ruled out by a CT/MRI scan before attempting incision and drainage or any other surgical procedure. Postoperative adjuvant radiotherapy is limited to high-grade tumors, incompletely excised tumors and more radiosensitive liposarcoma subtypes such as myxoid sarcomas.</p>

Review of Atypical Lipoma and its Natural Treatment

Atypical lipomatous are rare tumors that typically arise out of soft tissues in the body and common in adults. Most lipomas comprise of mature fat cells that exhibit characteristic of benign tumor by nature. They are round, motile, non-painful slow growing masses, with a characteristic soft and soggy feel, usually appear in the hypodermic area of skin. Atypical lipomas, though uncommon and slow growing can be associated with syndromes such as multiple hereditary lipomatosis, colorless adipose, Gardner's syndrome and Madelung's disease. While surgery has been the primary treatment modality, doctors have managed few patients with radiation therapy (RT). Median age of diagnosis was found in the range: 36–76 years but intramuscular lipomas may occur irrespective of age group, right from childhood to old age. However, the occurrence dominancy was found between the ages of 42 and 72 years, with the average age at presentation reported as 47 to 57 years.

A Twenty-Four-Year-Old Woman with Left Flank Lipoma-Like Hibernoma

A 24-year-old woman presented with a 5-month history of a left flank mass that was painful on palpation. Magnetic resonance imaging revealed a 10.0 × 6.0 × 2.5 cm mass consistent with lipoma. A fatty lobulated mass was excised and subjected to H&E staining and immunohistochemical analyses. The specimen consisted of mature univacuolated adipocytic cells, with intermixed multivacuolated eosinophilic granular cells. No atypia or hyperchromasia was identified. Most of the cells were S100 positive and Ki-67 immunonegative. A diagnosis of a lipoma-like hibernoma was rendered. Hibernomas are rare benign lipomatous tumors that show differentiation toward brown fat. The lipoma-like hibernoma subtype is rare and can be misdiagnosed as atypical lipoma or well-differentiated liposarcoma. Here we describe an example of this rare tumor.